4.8 Article

Hand-Held Raman Spectrometer-Based Dual Detection of Creatinine and Cortisol in Human Sweat Using Silver Nanoflakes

期刊

ANALYTICAL CHEMISTRY
卷 93, 期 45, 页码 14996-15004

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c02496

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资金

  1. Korea Institute of Machinery and Materials (KIMM) [NK232D]
  2. Ministry of Interior and Safety (MOIS, Korea) [2019-MOIS32-028]
  3. Korean government [NRF-2018R1A6A1A03025242, NRF-2021R1C1C1012822, NRF-2021R1F1A1063455]
  4. Korean government (the Ministry of Science and ICT) [202012D19]
  5. Research Resettlement Fund for the new faculty of the Kwangwoon University in 2021
  6. National Research Council of Science & Technology (NST), Republic of Korea [NK232D] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The paper presents a method for liquid biopsy analysis using SERS technology, including the fabrication of a SERS substrate with silver nanosnowflakes for simultaneous detection of creatinine and cortisol in human sweat.
The conventional tissue biopsy method yields isolated snapshots of a narrow region. Therefore, it cannot facilitate comprehensive disease characterization and monitoring. Recently, the detection of tumor-derived components in body fluids-a practice known as liquid biopsy-has attracted increased attention from the biochemical research and clinical application viewpoints. In this vein, surface-enhanced Raman scattering (SERS) has been identified as one of the most powerful liquid-biopsy analysis techniques, owing to its high sensitivity and specificity. Moreover, it affords high-capacity spectral multiplexing for simultaneous target detection and a unique ability to obtain intrinsic biomolecule-fingerprint spectra. This paper presents the fabrication of silver nanosnowflakes (SNSFs) using the polyol method and their subsequent dropping onto a hydrophobic filter paper. The SERS substrate, which comprises the SNSFs and hydrophobic filter paper, facilitates the simultaneous detection of creatinine and cortisol in human sweat using a hand-held Raman spectrometer. The proposed SERS system affords Raman spectrometry to be performed on small sample volumes (2 mu L) to identify the normal and at-risk creatinine and cortisol groups.

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