Reincarnation of the Analytical Ultracentrifuge: Emerging Opportunities for Nanomedicine

The analytical ultracentrifuge (AUC) and the modern field of analytical ultracentrifugation found its inception approximately a century ago. We highlight the scope of its major experimental opportunities as a transport-based method, contemporary and up-and-coming investigation potential for polymers, polymer-drug conjugates, polymer assemblies, as well as medical nanoparticles. Special focus lies on molar mass estimates of unimeric polymeric species, self-assemblies in solution, and (co)localization of multicomponent systems in solution alongside the material-biofluid interactions. We close with present challenges and incentives for future research.

Automated summary

The field of analytical ultracentrifugation, which originated approximately a century ago, is focused on the major experimental opportunities for polymers, polymer-drug conjugates, polymer assemblies, and medical nanoparticles. Special focus is on molar mass estimates of polymeric species, self-assemblies in solution, and localization of multicomponent systems in solution, with attention to material-biofluid interactions. The current challenges and future research incentives are also highlighted.