期刊
ANALYTICA CHIMICA ACTA
卷 1190, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aca.2021.339252
关键词
Micromixers; Direct infusion ionization; Microfluidic devices; Online monitoring; Mass spectrometry; 3D printing
资金
- CNPq [316553/2020-4, 426496/2018-3, 307554/2020-1]
- INCTBio [465389/2014-7]
The article discusses the development of a microfluidic mixing device fabricated entirely by 3D printing technology to monitor chemical reactions via mass spectrometry. Results showed that the device containing 3D serpentine channels had higher relative abundance values, making it a promising tool for monitoring organic reactions.
3D printing is a technology that has revolutionized traditional rapid prototyping methods due to its ability to build microscale structures with customized geometries in a simple, fast, and low-cost way. In this sense, this article describes the development of a microfluidic mixing device to monitor chemical reactions by mass spectrometry (MS). Microfluidic mixers were designed containing 3D serpentine and Y-shaped microchannels, both with a pointed end for facilitating the spray formation. The devices were fabricated entirely by 3D printing with fusion deposition modeling (FDM) technology. As proof-of-concept, micromixers were evaluated through monitoring the Katritzky reaction by injecting simulta-neously 2,4,6-triphenylpropyllium (TPP) and amino acid (glycine or alanine) solutions, each through a different reactor inlet. Reaction product was monitored online by MS at different flow rates. Mass spectra showed that the relative abundances of the products obtained with the device containing the 3D serpentine channel were three times greater than those obtained with the Y-channel device due to the turbulence generated by the barriers created inside microchannels. In addition, when compared to the conventional electrospray ionization mass spectrometry (ESI-MS) technique, the 3D serpentine mixer offered better performance measured in relation to the relative abundance values for the reaction products. These results as well as the instrumental simplicity indicate that 3D printed microfluidic mixer is a promising tool for monitoring organic reactions via MS. (c) 2021 Elsevier B.V. All rights reserved.
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