Simultaneous determination of multiple coupling networks by high- resolution 2D J-edited NMR spectroscopy

J coupling constitutes an important NMR parameter for molecular-level composition analysis and conformation elucidation. Dozens ofJ-based approaches have been exploited for J coupling measurement and coupling network determination, however, they are generally imposed to insufficient spectral resolution to resolve crowded NMR resonances and low measurement efficiency that a single experiment records one J coupling network. Herein, we propose a general NMR method to collect high-resolution 2D J-edited NMR spectra, which are characterized with advantages of pure absorptive lineshapes, decoupled chemical shift dimension, as well as eliminated axial peaks, thus facilitating J coupling partner assignments and J coupling constant measurements. More meaningfully, this protocol allows simultaneous determination of multiple coupling networks for highly efficient multiplet analyses via addressing multiple protons within one single experiment. Additionally, another variant is proposed for high resolution applications under adverse magnetic field conditions. Therefore, this study provides a useful NMR protocol for configurational and structural studies with extensive applications in chemistry, biology, and material science. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

A general NMR method has been proposed for collecting high-resolution 2D J-edited NMR spectra, facilitating J coupling partner assignments and measurements, and allowing simultaneous determination of multiple coupling networks for highly efficient multiplet analyses. Another variant for high resolution applications under adverse magnetic field conditions has also been suggested.