期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 22, 期 4, 页码 1261-1265出版社
ELSEVIER SCIENCE INC
DOI: 10.1111/ajt.16927
关键词
antibiotic: antiviral; clinical research/practice; heart transplantation/cardiology; immunobiology; infection and infectious agents-viral: SARS-CoV-2/COVID-19; infectious disease
资金
- AlloVir
An unvaccinated adult male heart transplant recipient with severe COVID-19 caused by the SARS-CoV-2 delta variant was successfully treated with ALVR109, leading to significant clinical and virologic improvements.
An unvaccinated adult male heart transplant recipient patient with recalcitrant COVID-19 due to SARS-CoV-2 delta variant with rising nasopharyngeal quantitative viral load was successfully treated with ALVR109, an off-the-shelf SARS-CoV-2-specific T cell therapy. Background immunosuppression included 0.1 mg/kg prednisone, tacrolimus, and mycophenolate mofetil 1 gm twice daily for historical antibody-mediated rejection. Prior therapies included remdesivir, corticosteroids, and tocilizumab, with requirement for high-flow nasal oxygen. Lack of clinical improvement and acutely rising nasopharyngeal viral RNA more than 3 weeks into illness prompted the request of ALVR109 through an emergency IND. The day following the first ALVR109 infusion, the patient's nasopharyngeal SARS-CoV-2 RNA declined from 7.43 to 5.02 log(10) RNA copies/ml. On post-infusion day 4, the patient transitioned to low-flow oxygen. Two subsequent infusions of ALVR109 were administered 10 and 26 days after the first; nasopharyngeal SARS-CoV-2 RNA became undetectable on Day 11, and he was discharged the following day on low-flow oxygen 5 weeks after the initial diagnosis of COVID-19. The clinical and virologic improvements observed in this patient following administration of ALVR109 suggest a potential benefit that warrants further exploration in clinical trials.
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