期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 22, 期 5, 页码 1451-1458出版社
WILEY
DOI: 10.1111/ajt.16952
关键词
clinical research/practice; donors and donation; donors and donation: donation after circulatory death (DCD); health services and outcomes research; organ procurement; organ procurement and allocation
资金
- US Department of Health and Human Services
- Health Resources and Services Administration (HRSA)
- Healthcare Systems Bureau, Division of Transplantation [HHSH250201900001C]
The study shows that the use of MPH in DCD procurements does not cause delays in WIT and does not negatively affect organ yield of other concurrently procured organs.
Successful normothermic machine perfusion of heart allografts (MPH) has led to rapid growth in transplantation of donation after circulatory death (DCD) heart allografts but has introduced complexity in the procurement process. This study examines the impact of MPH use in DCD procurements on warm ischemia time (WIT) and organ yield. DCD procurements from 2019 to 2020 were identified using the OPTN database. Procurements with and without the use of MPH were compared using propensity score matching. Observed to expected (O:E) yield ratios were calculated, where the expected values were obtained using the models developed by the Scientific Registry of Transplant Recipients. In total, 1237 DCD procurements met inclusion criteria (MPH: 109 and control: 1128). After PSM, no difference was found between groups in median total WIT (24.0 min vs. 24.0 min, p = .89), but the MPH group demonstrated shorter median operative WIT (circulatory arrest to cross-clamp; 8.7 min vs. 10.9 min, p = .003). The overall organ yield of DCD heart donors was observed to be 33% higher than expected (O:E 1.33; 95% CI: 1.22-1.45). Observed yield of non-heart organs was not significantly different from expected for liver, kidney, lung, and pancreas grafts. MPH use in DCD procurements does not lead to delays in WIT and does not negatively affect organ yield of other concurrently procured organs.
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