期刊
AMERICAN JOURNAL OF SURGERY
卷 223, 期 3, 页码 539-542出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2021.11.017
关键词
Complete response; Neoadjuvant chemotherapy; Breast cancer; Hispanic
类别
This study assessed prognostic factors associated with relapse-free survival after neoadjuvant chemotherapy for breast cancer. The findings showed that pathologic complete response, node-negativity after neoadjuvant chemotherapy, and triple-negative subtype were associated with better relapse-free survival.
Background: This study was designed to assess prognostic factors associated with relapse-free survival (RFS) after neoadjuvant chemotherapy (NAC) for breast cancer.Methods: A single-institution retrospective analysis was performed including clinical, radiographic, and pathologic parameters for all breast cancer patients treated with NAC from 2015 to 2018. All patients had pre-and post-NAC MRI.Results: For 102 patients, median follow-up was 47.4 months, and the five-year RFS was 74%. The 41 (40%) patients who achieved pathologic complete response (pCR) after NAC had a significantly higher five-year RFS than the 61 not achieving pCR. For 31 patients with triple-negative cancers, the five-year RFS was significantly higher in those achieving pCR vs. no pCR. The 44 (43%) patients who achieved radiographic complete response (rCR) after NAC had similar five-year RFS to the 58 (57%) not achieving rCR.Conclusion: pCR, node-negativity after NAC, and triple-negative subtype were prognostic factors associated with relapse-free survival after NAC.
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