4.7 Editorial Material

Hypoxia and Sleep-disordered Breathing Friend or Foe?

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Article Critical Care Medicine

Daily Exposure to Mild Intermittent Hypoxia Reduces Blood Pressure in Male Patients with Obstructive Sleep Apnea and Hypertension

Gino S. Panza et al.

Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Sleep Apnea-Specific Hypoxic Burden and Not the Sleepy Phenotype as a Novel Measure of Cardiovascular and Mortality Risk in a Clinical Cohort

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality

Wojciech Trzepizur et al.

Summary: This study aimed to evaluate whether symptom subtypes and OSA-specific hypoxic burden are associated with the risk of major adverse CV events in a clinical setting. The results showed that HB and overall nocturnal hypoxemia were the only predictors of MACE, with a stronger association seen in younger patients and women.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

Article Critical Care Medicine

The Sleep Apnea-Specific Pulse-Rate Response Predicts Cardiovascular Morbidity and Mortality

Ali Azarbarzin et al.

Summary: The study suggests that obstructive sleep apnea patients with an elevated pulse-rate response may have increased risk of cardiovascular morbidity and mortality, especially in those with a significant hypoxic burden. This finding could be useful for risk stratification and patient selection in future clinical trials.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Influence of Obstructive Sleep Apnoea on Outcomes in Patients With ST Elevation Myocardial Infarction (STEMI): the Role of the Coronary Collateral Circulation

Usaid K. Allahwala et al.

Summary: Patients with documented OSA presenting with STEMI appear to have more robust coronary collaterals observed on angiography which likely mediates lower myocardial necrosis. Further investigation is needed to determine the broader implications of this finding on treatment.

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Mild obstructive sleep apnea increases hypertension risk, challenging traditional severity classification

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Mild-to-moderate sleep apnea is associated with incident hypertension: age effect

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Cardioprotection by intermittent hypoxia conditioning: evidence, mechanisms, and therapeutic potential

Robert T. Mallet et al.

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Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy

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Association between Obstructive Sleep Apnea and Cardiovascular Risk Factors: Variation by Age, Sex, and Race

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CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea

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Therapeutic potential of intermittent hypoxia: a matter of dose

Angela Navarrete-Opazo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2014)

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CPAP versus Oxygen in Obstructive Sleep Apnea

Daniel J. Gottlieb et al.

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Chronic intermittent hypoxia in humans during 28 nights results in blood pressure elevation and increased muscle sympathetic nerve activity

G. S. Gilmartin et al.

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Long-term facilitation of ventilation and genioglossus muscle activity is evident in the presence of elevated levels of carbon dioxide in awake humans

Daniel P. Harris et al.

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Acute sustained hypoxia suppresses the cough reflex in healthy subjects

DJ Eckert et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

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Sustained hypoxia depresses sensory processing of respiratory resistive loads

DJ Eckert et al.

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Hypoxia suppresses symptom perception in asthma

DJ Eckert et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)