Contribution of the von Willebrand factor/ADAMTS13 imbalance to COVID-19 coagulopathy

Article Hematology

Elevated fibrinogen and fibrin degradation product are associated with poor outcome in COVID-19 patients: A meta-analysis

Johanes Nugroho et al.

Summary: Elevated levels of fibrinogen and FDP upon admission in COVID-19 patients are associated with an increased risk of poor outcomes, suggesting that these parameters could be important indicators for predicting patient prognosis.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2021)

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Letter Cardiac & Cardiovascular Systems

Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells

Ian R. McCracken et al.

CIRCULATION (2021)

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Article Hematology

The ADAMTS13-von Willebrand factor axis in COVID-19 patients

Ilaria Mancini et al.

Summary: Severe COVID-19 patients exhibit an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients. The study found a significant alteration of the VWF-ADAMTS13 axis in COVID-19 patients, with an elevated VWF:Ag to ADAMTS13 activity ratio strongly associated with disease severity, enhancing the hypercoagulable state and risk of microthrombosis in these patients.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Review Cell Biology

SARS-CoV-2, ACE2 expression, and systemic organ invasion

Usman M. Ashraf et al.

Summary: The novel coronavirus disease COVID-19 has posed a global challenge by infecting human cells via binding with ACE2, resulting in respiratory illnesses like bronchitis and pneumonia.

PHYSIOLOGICAL GENOMICS (2021)

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Article Cardiac & Cardiovascular Systems

COVID-19 and thrombosis: From bench to bedside

Mohammad A. M. Ali et al.

Summary: COVID-19 is a respiratory viral infection caused by the coronavirus SARS-CoV2, which has been found to increase the risk of venous and arterial thromboembolic events. There is growing attention from the scientific community on the link between COVID-19 and thrombosis.

TRENDS IN CARDIOVASCULAR MEDICINE (2021)

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Letter Hematology

Increased von Willebrand factor antigen and low ADAMTS13 activity are related to poor prognosis in covid-19 patients

Mario Rodriguez Rodriguez et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Von Willebrand factor and ADAMTS13 activity as clinical severity markers in patients with COVID-19

A. Marco et al.

Summary: This study aimed to evaluate endothelial injury markers (VWF antigen and plasma ADAMTS13 activity) in COVID-19 patients and found that COVID-19 patients had an increase in VWF antigen and a decrease in ADAMTS13 activity, which were associated with disease severity and could predict poor clinical outcomes.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Article Hematology

Recombinant ADAMTS13 reduces abnormally up-regulated von Willebrand factor in plasma from patients with severe COVID-19

Peter L. Turecek et al.

Summary: Thrombosis is common in severe COVID-19 patients, with an imbalance of VWF/ADAMTS13 implicated in its pathogenesis. Correction of this imbalance through rADAMTS13 may help restore hemostatic balance and potentially serve as a therapeutic approach in severe COVID-19 cases.

THROMBOSIS RESEARCH (2021)

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Article Multidisciplinary Sciences

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

Nicholas A. Arce et al.

Summary: The study reveals that the mechanism for activating Von Willebrand factor (VWF) in response to mechanical force is located in the autoinhibitory module, which can be unfolded by tensile force to activate VWF. Certain mutations or external factors can also affect the unfolding force of the module, thus influencing the activation of VWF. This research contributes to understanding the mechanical regulation of VWF and its potential applications.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients

Jingrui Sui et al.

Summary: COVID-19 patients commonly have elevated fibrinogen levels, especially in those with severe disease. Elevated fibrinogen is correlated with excessive inflammation, disease severity, and ICU admission in COVID-19 patients.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Hematology

Inflammatory and Prothrombotic Biomarkers Associated With the Severity of COVID-19 Infection

Sandra Lopez-Castaneda et al.

Summary: In hospitalized COVID-19 patients, alterations in inflammatory and coagulation biomarkers are closely related to poor prognosis, with significantly elevated levels of D-dimer and PAI-1 in severe cases, along with distinct differences in inflammatory markers between non-severe patients and those who succumbed to the disease.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

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Article Hematology

Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality

Fien A. von Meijenfeldt et al.

Summary: The study found that COVID-19 patients with higher levels of respiratory support have significantly increased in vivo activation of coagulation and fibrinolysis, despite receiving anticoagulant therapy. Blood markers such as fibrinogen, von Willebrand factor, etc., also change with increasing levels of respiratory support.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

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Letter Cardiac & Cardiovascular Systems

Letter to the Editor: Angiotensin-converting enzyme 2: an ally or a Trojan horse? Implications to SARS-CoV-2-related cardiovascular complications

Zaid Abassi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

COVID-19, ACE2, and the cardiovascular consequences

Andrew M. South et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Article Medicine, General & Internal

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

Dominic Wichmann et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Letter Hematology

Involvement of ADAMTS13 and von Willebrand factor in thromboembolic events in patients infected with SARS-CoV-2

Albert Huisman et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Acute Pulmonary Embolism and COVID-19

Neo Poyiadji et al.

RADIOLOGY (2020)

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Letter Hematology

ADAMTS13 activity, von Willebrand factor, factor VIII and D-dimers in COVID-19 inpatients

R. Escher et al.

THROMBOSIS RESEARCH (2020)

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Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

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Article Hematology

D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19

Litao Zhang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Incidence of venous thromboembolism in hospitalized patients with COVID-19

Saskia Middeldorp et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Hematology

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

Hanny Al-Samkari et al.

BLOOD (2020)

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Editorial Material Hematology

COVID-19 coagulopathy, thrombosis, and bleeding

Noel C. Chan et al.

BLOOD (2020)

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Letter Medicine, General & Internal

Low ADAMTS 13 plasma levels are predictors of mortality in COVID-19 patients

Mario Bazzan et al.

INTERNAL AND EMERGENCY MEDICINE (2020)

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Article Hematology

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

George Goshua et al.

LANCET HAEMATOLOGY (2020)

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Editorial Material Hematology

Coagulation abnormalities and thrombosis in patients with COVID-19

Marcel Levi et al.

LANCET HAEMATOLOGY (2020)

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Article Pediatrics

Cardiac dysfunction and thrombocytopenia-associated multiple organ failure inflammation phenotype in a severe paediatric case of COVID-19

Gwynne Latimer et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

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Letter Medicine, General & Internal

Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)

Julien Nahum et al.

JAMA NETWORK OPEN (2020)

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Article Hematology

In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID-19 patients on anticoagulation

Annabel Blasi et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Letter Hematology

Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom

W. Thomas et al.

THROMBOSIS RESEARCH (2020)

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Article Hematology

Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy

Corrado Lodigiani et al.

THROMBOSIS RESEARCH (2020)

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Letter Hematology

A relative ADAMTS13 deficiency supports the presence of a secondary microangiopathy in COVID 19

Nicola Martinelli et al.

THROMBOSIS RESEARCH (2020)

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Letter Hematology

A comprehensive assessment of the coagulation profile in critically ill COVID-19 patients

E. H. Adam et al.

THROMBOSIS RESEARCH (2020)

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Article Medicine, General & Internal

Prognostic Value of Fibrinogen among COVID-19 Patients Admitted to an Emergency Department: An Italian Cohort Study

Pierpaolo Di Micco et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Hematology

von Willebrand factor/ADAMTS13 ratio at presentation of acute ischemic brain injury is predictive of outcome

Alice Taylor et al.

BLOOD ADVANCES (2020)

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Editorial Material Chemistry, Physical

Platelet mechanosensing axis revealed

X. Frank Zhang et al.

NATURE MATERIALS (2019)

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Review Hematology

von Willebrand factor/ADAMTS-13 interactions at birth: implications for thrombosis in the neonatal period

Upendra K. Katneni et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2019)

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Article Medicine, General & Internal

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura

M. Scully et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Hematology

Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura

Marie Scully et al.

BLOOD (2017)

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Article Cardiac & Cardiovascular Systems

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi

Sara Martinez de Lizarrondo et al.

CIRCULATION (2017)

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Article Medicine, General & Internal

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

Flora Peyvandi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Multidisciplinary Sciences

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

Wei Deng et al.

NATURE COMMUNICATIONS (2016)

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Review Medicine, Research & Experimental

ADAMTS13 and von Willebrand Factor in Thrombotic Thrombocytopenic Purpura

X. Long Zheng

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

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Article Hematology

Low ADAMTS13 activity is associated with an increased risk of ischemic stroke

M. A. H. Sonneveld et al.

BLOOD (2015)

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Article Hematology

Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease

Joan C. Gill et al.

BLOOD (2015)

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Review Cardiac & Cardiovascular Systems

Endothelial cell control of thrombosis

Jonathan W. Yau et al.

BMC CARDIOVASCULAR DISORDERS (2015)

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Review Hematology

von Willebrand factor, Jedi knight of the bloodstream

Timothy A. Springer

BLOOD (2014)

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Review Hematology

Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic review and meta-analysis

Michelle A. H. Sonneveld et al.

BLOOD REVIEWS (2014)

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Review Cardiac & Cardiovascular Systems

Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

Fiona A. Martin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

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Article Hematology

High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women

Helena M. Andersson et al.

BLOOD (2012)

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Article Hematology

Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs

Hans Ulrichts et al.

BLOOD (2011)

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Article Clinical Neurology

High von Willebrand factor levels increase the risk of first ischemic stroke -: Influence of ADAMTS13, inflammation, and genetic variability

Tamara N. Bongers et al.

STROKE (2006)

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Review Cardiac & Cardiovascular Systems

Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function

CM Ferrario et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

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Article Hematology

Fibrinogen and fibrin structure and functions

MW Mosesson

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)

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Article Hematology

P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface

A Padilla et al.

BLOOD (2004)

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Contribution of the von Willebrand factor/ADAMTS13 imbalance to COVID-19 coagulopathy

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