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SCIENTIFIC REPORTS (2015)
NAD+-Metabolizing Ectoenzymes in Remodeling Tumor-Host Interactions: The Human Myeloma Model
Alberto L. Horenstein et al.
CELLS (2015)
The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
T. Vaisitti et al.
LEUKEMIA (2015)
CD38 Is Expressed on Inflammatory Cells of the Intestine and Promotes Intestinal Inflammation
Michael Schneider et al.
PLOS ONE (2015)
Daratumumab and its potential in the treatment of multiple myeloma: overview of the preclinical and clinical development
Colin Phipps et al.
THERAPEUTIC ADVANCES IN HEMATOLOGY (2015)
Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle
Eija Pirinen et al.
CELL METABOLISM (2014)
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5
Minjia Tan et al.
CELL METABOLISM (2014)
CD38 and E2F transcription factor 2 have uniquely increased expression in rheumatoid arthritis synovial tissues
X. Chang et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2014)
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors
Claudia C. S. Chini et al.
CLINICAL CANCER RESEARCH (2014)
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging
Liana R. Stein et al.
EMBO JOURNAL (2014)
Exogenous NAD+ supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway
Ling Liu et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2014)
Ductular Reaction in Hereditary Hemochromatosis: The Link Between Hepatocyte Senescence and Fibrosis Progression
Marnie J. Wood et al.
HEPATOLOGY (2014)
Revealing CD38 Cellular Localization Using a Cell Permeable, Mechanism-Based Fluorescent Small-Molecule Probe
Jonathan H. Shrimp et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Claudio Franceschi et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Daniel Kraus et al.
NATURE (2014)
Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues
Valerio Mori et al.
PLOS ONE (2014)
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Ana P. Gomes et al.
CELL (2013)
Proteasome Regulation by ADP-Ribosylation
Park F. Cho-Park et al.
CELL (2013)
NAD+ metabolism: A therapeutic target for age-related metabolic disease
Laurent Mouchiroud et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)
Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients
Esther J. Pavon et al.
CYTOKINE (2013)
CD38 and CD157: A long journey from activation markers to multifunctional molecules
Valeria Quarona et al.
CYTOMETRY PART B-CLINICAL CYTOMETRY (2013)
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
Carlos Escande et al.
DIABETES (2013)
Underestimation of Liver-Related Mortality in the United States
Sumeet K. Asrani et al.
GASTROENTEROLOGY (2013)
Circulating CD4+ and CD8+ T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation
Nicholas T. Funderburg et al.
IMMUNOLOGY (2013)
CD38 Controls the Innate Immune Response against Listeria monocytogenes
Timo Lischke et al.
INFECTION AND IMMUNITY (2013)
CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells
Alessia Grozio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease
Aloysious Aravinthan et al.
JOURNAL OF HEPATOLOGY (2013)
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
Hong Jiang et al.
NATURE (2013)
Hepatocyte Expression of the Senescence Marker p21 Is Linked to Fibrosis and an Adverse Liver-Related Outcome in Alcohol-Related Liver Disease
Aloysious Aravinthan et al.
PLOS ONE (2013)
A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes
Alberto L. Horenstein et al.
ONCOIMMUNOLOGY (2013)
Thromboxane-induced renal vasoconstriction is mediated by the ADP-ribosyl cyclase CD38 and superoxide anion
Nicholas G. Moss et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)
Protein Lysine Acylation and Cysteine Succination by Intermediates of Energy Metabolism
Hening Lin et al.
ACS CHEMICAL BIOLOGY (2012)
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
Caries Canto et al.
CELL METABOLISM (2012)
Mitochondrial protein acetylation regulates metabolism
Kristin A. Anderson et al.
LYSINE-BASED POST-TRANSLATIONAL MODIFICATION OF PROTEINS (2012)
Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization
Hon Cheung Lee
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis
Krishna M. Boini et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)
Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue
Hassina Massudi et al.
PLOS ONE (2012)
The NAD metabolome - a key determinant of cancer cell biology
Alberto Chiarugi et al.
NATURE REVIEWS CANCER (2012)
Amyloid Precursor Protein Processing and Alzheimer's Disease
Richard J. O'Brien et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)
Pathway analysis of NAD+ metabolism
Luis F. de Figueiredo et al.
BIOCHEMICAL JOURNAL (2011)
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Agnieszka A. Kendrick et al.
BIOCHEMICAL JOURNAL (2011)
CD38 and chronic lymphocytic leukemia: a decade later
Fabio Malavasi et al.
BLOOD (2011)
Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
Jun Yoshino et al.
CELL METABOLISM (2011)
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
Peter Bai et al.
CELL METABOLISM (2011)
NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway
Li Zhuo et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2011)
CD38: A NAADP degrading enzyme
Frederike Schmid et al.
FEBS LETTERS (2011)
Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media
A. Overman et al.
INTERNATIONAL JOURNAL OF OBESITY (2011)
Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors
Michel de Weers et al.
JOURNAL OF IMMUNOLOGY (2011)
TRPM2: a multifunctional ion channel for calcium signalling
Adriana Sumoza-Toledo et al.
JOURNAL OF PHYSIOLOGY-LONDON (2011)
Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice
Lu Gan et al.
LIFE SCIENCES (2011)
MECHANISMS OF DISEASE Systemic Lupus Erythematosus
George C. Tsokos
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Absence of CD38 delays arrival of neutrophils to the liver and innate immune response development during hepatic amoebiasis by Entamoeba histolytica
L. A. Estrada-Figueroa et al.
PARASITE IMMUNOLOGY (2011)
Age Related Changes in NAD plus Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (Publication with Expression of Concern. See vol. 17, 2022)
Nady Braidy et al.
PLOS ONE (2011)
Knocking out of CD38 accelerates development of a lupus-like disease in lpr mice
Marta S. Viegas et al.
RHEUMATOLOGY (2011)
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Jintang Du et al.
SCIENCE (2011)
Inflammatory Bowel Disease
Arthur Kaser et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)
CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia Cells
Silvia Deaglio et al.
MOLECULAR MEDICINE (2010)
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey et al.
NATURE (2010)
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
Erika Koltai et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2010)
The predictive value of CD38 positive hepatic stellate cell count for assessing disease activity and fibrosis in patients with chronic hepatitis
Suad M. Abdeen et al.
ACTA HISTOCHEMICA (2009)
CD38 Plays a Dual Role in Allergen-Induced Airway Hyperresponsiveness
Fabienne Gally et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)
Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy
Rukhsana Gul et al.
CARDIOVASCULAR RESEARCH (2009)
CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions
Eduardo Nunes Chini
CURRENT PHARMACEUTICAL DESIGN (2009)
NAADP mobilizes calcium from acidic organelles through two-pore channels
Peter J. Calcraft et al.
NATURE (2009)
A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT
Emmanuel S. Burgos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Infiltrations of plasma cells in synovium are highly associated with synovial fluid levels of APRIL in inflamed peripheral joints of rheumatoid arthritis
Weijia Dong et al.
RHEUMATOLOGY INTERNATIONAL (2009)
Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine
Tiffany L. Thai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)
Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: role of dual specificity phosphatase 1
Bit Na Kang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase
Emmanuel S. Burgos et al.
BIOCHEMISTRY (2008)
Joseph Goldberger's research on the prevention of pellagra
Alfredo Morabia
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2008)
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
Shinichiro Yamamoto et al.
NATURE MEDICINE (2008)
Hepatic steatosis: A benign disease or a silent killer
Abdel-Rahman El-Zayadi
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-Ribose, the major product generated by the CD38 enzyme reaction
Santiago Partida-Sanchez et al.
JOURNAL OF IMMUNOLOGY (2007)
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
Maria Thereza P. Barbosa et al.
FASEB JOURNAL (2007)
Nicotinamide riboside kinase structures reveal new pathways to NAD
Wolfram Tempel et al.
PLOS BIOLOGY (2007)
Early interstitial lung disease in familial pulmonary fibrosis
Ivan O. Rosas et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells
Nobumasa Hara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
Anja Schuetz et al.
STRUCTURE (2007)
Role of cell-cycle turnover and oxidative stress in telomere shortening and cellular senescence in patients with chronic hepatitis C
Satoru Sekoguchi et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2007)
NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells
Sandra Soares et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge
Alonso G. P. Guedes et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)
Regulation of SIRT 1 mediated NAD dependent deacetylation: A novel role for the multifunctional enzyme CD38
Pinar Aksoy et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line
Luisa Franco et al.
JOURNAL OF NEUROCHEMISTRY (2006)
SIRT4 inhibits glutamate dehydrogehase and opposes the effects of calorie restriction in pancreatic β cells
Marcia C. Haigis et al.
CELL (2006)
Decreased cADPR and increased NAD+ in the Cd38-/- mouse
Genevieve S. Young et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Regulation of intracellular levels of NAD: A novel role for CD38
Pinar Aksoy et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
A topoisomerase IIβ-mediated dsDNA break required for regulated transcription
BG Ju et al.
SCIENCE (2006)
CD38 as a prognostic factor in BCeH chronic lymphocytic leukaemia (B-CLL): Comparison of three approaches to analyze its expression
JG Boonstra et al.
CYTOMETRY PART B-CLINICAL CYTOMETRY (2006)
Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells
EJ Pavón et al.
MOLECULAR IMMUNOLOGY (2006)
Altered CD38 expression in thioacetamide-induced rat model of liver cirrhosis
BH Gan et al.
LIVER INTERNATIONAL (2005)
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
G Liszt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection
A Marshall et al.
GASTROENTEROLOGY (2005)
Altered airway responsiveness in CD38-deficient mice
DA Deshpande et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2005)
Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals
TW Chun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Principal component for metabolic syndrome risk maps to chromosome 4p in Mexican Americans: The San Antonio Family Heart Study
GW Cai et al.
HUMAN BIOLOGY (2004)
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
JR Revollo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Changes in CD38 expression and ADP-ribosyl cyclase activity in rat myometrium during pregnancy: Influence of sex steroid hormones
S Dogan et al.
BIOLOGY OF REPRODUCTION (2004)
Mechanisms of pulmonary fibrosis
VJ Thannickal et al.
ANNUAL REVIEW OF MEDICINE (2004)
Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender
J Takahashi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Increased numbers of CD38 molecules on bright CD8+ T lymphocytes in infectious mononucleosis caused by Epstein-Barr virus infection
SZ Lepej et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2003)
Nicotinamide ribosyl uptake mutants in Haemophilus influenzae
M Herbert et al.
INFECTION AND IMMUNITY (2003)
Molecular identification of human glutamine- and ammonia-dependent NAD synthetases - Carbon-nitrogen hydrolase domain confers glutamine dependency
N Hara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Obesity is associated with macrophage accumulation in adipose tissue
SP Weisberg et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
HY Xu et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1
KJ Bitterman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The cyclic-ADP-ribose signaling pathway in human myometrium
EN Chini et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?
EN Chini et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues
EN Chini et al.
BIOCHEMICAL JOURNAL (2002)
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
S Partida-Sánchez et al.
NATURE MEDICINE (2001)
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
JA Eaden et al.
GUT (2001)
Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
V Paradis et al.
HUMAN PATHOLOGY (2001)
Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users
J Carbone et al.
AIDS (2000)