期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 321, 期 6, 页码 C992-C999出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00211.2021
关键词
electrophysiology; hippocampus; thirst; water intake
资金
- National Natural Science Foundation of China [91732107, 81571067, 81521063, 31872774]
- National Key R&D Program of China [2017YFA0701302]
- Key Project of Chinese Ministry of Education [109003]
The study found that inhibiting the activity of pyramidal neurons in the ventral hippocampal CA1 area increases water intake in rats. The results suggest that the hippocampus plays an important role in regulating drinking behavior, but the specific mechanisms need further investigation.
Thirst is an important interoceptive response and drives water consumption. The hippocampus actively modulates food intake and energy metabolism, but direct evidence for the exact role of the hippocampus in modulating drinking behaviors is lacking. We observed decreased number of c-Fos-positive neurons in the ventral hippocampal CA1 (vCA1) after water restriction or hypertonic saline injection in rats. Suppressed vCA1 neuronal activities under the hypertonic state were further confirmed with in vivo electrophysiological recording, and the level of suppression paralleled both the duration and the total amount of water consumption. Chemogenetic inhibition of vCA1 pyramidal neurons increased water consumption in rats injected with both normal and hypertonic saline. These findings suggest that suppression of vCA1 pyramidal neuronal activities enhances water intake.
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