期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 192, 期 5, 页码 750-761出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2022.02.001
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资金
- NIH [HL141195]
Lung fibrosis is characterized by the accumulation of ECM proteins by apoptosis-resistant fibroblasts. Lung epithelial injury leads to fibroblast recruitment and activation, which are necessary for tissue repair. However, under pathological conditions, a vicious cycle of profibrotic factors and cell-matrix signaling promotes the development of lung fibrosis characterized by increased ECM proteins and changes in matrix properties. Understanding the role of ECM in fibrosis can lead to new therapeutic targets and improved outcomes.
Lung fibrosis is characterized by the continuous accumulation of extracellular matrix (ECM) proteins produced by apoptosis-resistant (myo)fibroblasts. Lung epithelial injury promotes the recruitment and activation of fibroblasts, which are necessary for tissue repair and restoration of homeostasis. However, under pathologic conditions, a vicious cycle generated by profibrotic growth factors/cytokines, multicellular interactions, and matrix-associated signaling propagates the wound repair response and promotes lung fibrosis characterized not only by increased quantities of ECM proteins but also by changes in the biomechanical properties of the matrix. Importantly, changes in the biochemical and biomechanical properties of the matrix itself can serve to perpetuate fibroblast activity and propagate fibrosis, even in the absence of the initial stimulus of injury. The development of novel experimental models and methods increasingly facilitates our ability to interrogate fibrotic processes at the cellular and molecular levels. The goal of this review is to discuss the impact of ECM conditions in the development of lung fibrosis and to introduce new approaches to more accurately model the in vivo fibrotic microenvironment. This article highlights the pathologic roles of ECM in terms of mechanical force and the cellular interactions while reviewing in vitro and ex vivo models of lung fibrosis. The improved understanding of the fundamental mechanisms that contribute to lung fibrosis holds promise for identification of new therapeutic targets and improved outcomes.& nbsp;
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