4.6 Article

Predictive factors of outcomes in patients with AL amyloidosis treated with daratumumab

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

A pharmacist's review of the treatment of systemic light chain amyloidosis

David M. Hughes et al.

Summary: Systemic light-chain (AL) amyloidosis is a rare hematologic disorder with treatment options overlapping with multiple myeloma. Frontline options include high-dose melphalan and bortezomib-based regimens, while relapsed settings may involve a variety of agents like bortezomib, ixazomib, and lenalidomide. The treatment landscape for AL amyloidosis is expanding with novel agents used in multiple myeloma being repurposed and adapted.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2021)

Editorial Material Biochemistry & Molecular Biology

Clarification on the definition of complete haematologic response in light-chain (AL) amyloidosis

Giovanni Palladini et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2021)

Review Cell Biology

Daratumumab in the Treatment of Light-Chain (AL) Amyloidosis

Giovanni Palladini et al.

Summary: AL amyloidosis is caused by a small B cell clone producing toxic light chains, and the addition of daratumumab to standard treatment has shown promising results in increasing hematologic response rates and organ responses. Anti-CD38 antibodies like daratumumab offer new powerful tools for treating AL amyloidosis, potentially becoming new standards of care.
Article Hematology

Haematologic responses and survival do not significantly decrease with subsequent lines of therapy in systemic immunoglobulin light chain amyloidosis: results from an analysis of real-world longitudinal data

Sriram Ravichandran et al.

Summary: Although relapses occur in AL amyloidosis, the outcomes and responses do not worsen with each subsequent relapse, making it attractive to design therapeutics with curative intent.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Medicine, General & Internal

Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial

Philippe Moreau et al.

Summary: The study showed that the addition of isatuximab to carfilzomib-dexamethasone significantly improves progression-free survival and depth of response in patients with relapsed multiple myeloma, representing a new standard of care for this patient population.

LANCET (2021)

Article Medicine, General & Internal

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis

E. Kastritis et al.

Summary: In patients with newly diagnosed AL amyloidosis, adding daratumumab to bortezomib, cyclophosphamide, and dexamethasone resulted in higher rates of hematologic complete response and improved survival outcomes. However, adverse events, including lymphopenia, pneumonia, cardiac failure, and diarrhea, were more common in the daratumumab group. Most deaths were due to amyloidosis-related cardiomyopathy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Biochemistry & Molecular Biology

Treatment with daratumumab in patients with relapsed/refractory AL amyloidosis: a multicentric retrospective study and review of the literature

Ramon Lecumberri et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2020)

Article Biochemistry & Molecular Biology

Presence of t(11;14) in AL amyloidosis as a marker of response when treated with a bortezomib-based regimen

Brett Dumas et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2020)

Article Education, Scientific Disciplines

Management of AL amyloidosis in 2020

Giovanni Palladini et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2020)

Letter Biochemistry & Molecular Biology

Daratumumab activity in relapsed or primary refractory systemic AL amyloidosis and Fcγ receptor 3A V158F polymorphisms

Lisa Xingguang Lee et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2019)

Article Medicine, General & Internal

Systemic immunoglobulin light chain amyloidosis

Giampaolo Merlini et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Biochemistry & Molecular Biology

Gain of chromosome 1q21 is an independent adverse prognostic factor in light chain amyloidosis patients treated with melphalan/dexamethasone

Tilmann Bochtler et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2014)