Oxidative Stress Mediates the Association Between Dietary Fat Intake and Cognition in US Older Adults

OBJECTIVE: Dietary fat intake was considered as a modifiable factor influencing cognitive performance. The objective was to 1) examine the associations between different types of dietary fat intakes and cognitive outcomes among elder adults (& GE;60 years old); 2) assess whether peripheral oxidative stress and antioxidant biomarkers are potential mediators of dietary fat intake and cognitive impairment relationship. METHODS: Using data from National Health and Nutrition Examination Survey 2011-2014, total fat, saturated fatty acid (SFAT), monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), cholesterol, co-3 and co-6 fatty acids were used to evaluate dietary fat intakes. Cognitive outcomes were assessed by word learning and recall modules from the consortium to establish a registry for Alzheimer's Disease (CERAD), animal fluency test, and digit symbol substitution test (DSST). Antioxidant biomarkers were assessed by gamma glutamyl transpeptidase (GGT), bilirubin, uric acid, and vitamin D levels. Linear regression models and causal mediation analysis were applied to quantify the associations. RESULTS: A total of 2,253 elder adults were included in the data analyses. Dietary intake of PUFA and co-6 fatty acid were positively associated with DSST [beta (95% CI): 0.06 (0.01,0.10), t statistic = 2.39, df= 2238, p = 0.02; beta (95% CI): 0.06 (0.01,0.11), t statistic = 2.54, df= 2238, p = 0.01, respectively]. GGT was negatively associated with DSST [beta (95% CI):-0.04 (-0.07,-0.01), t statistic =-2.73, df= 2239, p = 0.01], whereas uric acid was positively associated with CERAD total score [beta (95% CI): 0.04 (0.00,0.08), t statistic = 2.03, df= 2233, p = 0.04]. The association between dietary intake of PUFA/w-3/w-6 and DSST performance was partially mediated by GGT level. CONCLUSION: Our findings support that PUFAs in dietary sources were associated with lower risks for cognitive impairment partially via lowering oxidative stress. Dietary PUFA supplementation may potentially reduce risk of cognitive impairment via antioxidative mechanism

Automated summary

The objective of this study was to examine the associations between different types of dietary fat intakes and cognitive outcomes among elder adults. The results showed that dietary intake of PUFA and co-6 fatty acid were positively associated with cognitive performance, while GGT was negatively associated. Uric acid was positively associated with cognitive scores. The findings suggest that dietary PUFAs may reduce the risk of cognitive impairment by lowering oxidative stress.