Challenges in Systematic Reviews and Meta-Analyses of Mediation Analyses

Systematic reviews and meta-analyses of mediation studies are increasingly being implemented in practice. Nonetheless, the methodology for conducting such review and analysis is still in a development phase, with much room for improvement. In this paper, we highlight and discuss challenges that investigators face in systematic reviews and meta-analyses of mediation studies and propose ways of accommodating these in practice.

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This paper discusses the challenges faced by investigators in systematic reviews and meta-analyses of mediation studies and proposes ways to address these challenges in practice.