期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 115, 期 1, 页码 34-44出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/nqab329
关键词
dicarbonyls; diet; skin autofluorescence; advanced glycation end products; type 2 diabetes; cardiovascular complications; glycation; methylglyoxal
资金
- Netherlands Food and Consumer Product Safety Authority (NVWA)
- Healthsimilar toHolland, Top Sector Life Sciences Health
- ERA-NET Cofund HDHL INTIMIC [727565]
- European Regional Development Fund via OP-Zuid
- Province of Limburg
- Dutch Ministry of Economic Affairs [31O.041]
- Stichting De Weijerhorst (Maastricht, the Netherlands)
- Pearl String Initiative Diabetes (Amsterdam, the Netherlands
- Cardiovascular Center (CVC
- Maastricht)
- CARIM School for Cardiovascular Diseases (Maastricht)
- CAPHRI Care and Public Health Research Institute (Maastricht)
- NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht)
- Stichting Annadal (Maastricht)
- Health Foundation Limburg (Maastricht)
- Janssen-Cilag B.V. (Tilburg, the Netherlands)
- Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands)
- Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)
The study aimed to investigate the association of dietary dicarbonyl intake with plasma dicarbonyl concentrations and skin AGEs in a population-based study. The findings revealed that higher intake of dietary MGO and GO was positively associated with corresponding plasma concentrations, while intake of 3-DG showed no significant association. These results suggest potential dietary absorption of MGO and GO, highlighting the importance of further research on the biological implications of dietary absorption of these compounds.
Background: Dicarbonyls are highly reactive compounds and major precursors of advanced glycation end products (AGEs). Both dicarbonyls and AGEs are associated with development of age-related diseases. Dicarbonyls are formed endogenously but also during food processing. To what extent dicarbonyls from the diet contribute to circulating dicarbonyls and AGEs in tissues is unknown. Objectives: To examine cross-sectional associations of dietary dicarbonyl intake with plasma dicarbonyl concentrations and skin AGEs. Methods: In 2566 individuals of the population-based Maastricht Study (age: 60 +/- 8 y, 50% males, 26% with type 2 diabetes), we estimated habitual intake of the dicarbonyls methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) by combining FFQs with our dietary dicarbonyl database of MGO, GO, and 3-DG concentrations in> 200 commonly consumed food products. Fasting plasma concentrations of MGO, GO, and 3-DG were measured by ultra-performance liquid chromatography-tandem mass spectrometry. Skin AGEs were measured as skin autofluorescence (SAF), using theAGE Reader. Associations of dietary dicarbonyl intake with their respective plasma concentrations and SAF (all standardized) were examined using linear regression models, adjusted for age, sex, potential confounders related to cardiometabolic risk factors, and lifestyle. Results: Median intake of MGO, GO, and 3-DG was 3.6, 3.5, and 17 mg/d, respectively. Coffee was the main dietary source of MGO, whereas this was bread for GO and 3-DG. In the fully adjusted models, dietary MGO was associated with plasma MGO (beta: 0.08; 95% CI: 0.02, 0.13) and SAF (beta: 0.12; 95% CI: 0.07, 0.17). Dietary GO was associated with plasma GO (beta: 0.10; 95% CI: 0.04, 0.16) but not with SAF. 3-DG was not significantly associated with either plasma 3-DG or SAF. Conclusions: Higher habitual intake of dietary MGO and GO, but not 3-DG, was associated with higher corresponding plasma concentrations. Higher intake of MGO was also associated with higher SAF. These results suggest dietary absorption of MGO and GO. Biological implications of dietary absorption of MGO and GO need to be determined. The study has been approved by the institutional medical ethical committee (NL31329.068.10) and the Minister of Health, Welfare and Sports of the Netherlands (Permit 131088-105234-PG).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据