期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 50, 期 1, 页码 53-90出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X22500033
关键词
Ganoderma Lucidum Polysaccharides; Pharmacological Rationales; Molecular Mechanisms; Network Pharmacology; Review
资金
- Macau Centre for Research and Development in Chinese Medicine [FDCT/007/2020/ALC]
- Research Fund of University of Macau [CPG2021-00022-ICMS]
- Natural Sciences Foundation for Young Scientists of China [82104494]
Ganoderma lucidum polysaccharides (GLPs) have been extensively studied for their therapeutic effects, but the exact mechanisms and pathways still require further research.
As a versatile Chinese herb, Ganoderma lucidum (Leyss. ex Fr.) Karst (G. lucidum) has been applied to treat multiple diseases in clinics and improve the quality of life of patients. Among all of its extracts, the main bioactive components are G. lucidum polysaccharides (GLPs), which possess many therapeutic effects, such as antitumor, immunoregulatory, anti-oxidant, antidiabetic, antibacterial, and antifungal effects and neuroprotection activities. This review briefly summarized the recent studies of the pharmacological rationales of GLPs and their underlying molecular signaling transmission mechanisms in treating diseases. Until now, the clear mechanisms of GLPs for treating diseases have not been reported. In this review, we used the keywords of Ganoderma lucidum polysaccharides and tumor to search in PubMed (years of 1992-2020), then screened and obtained 160 targets of antitumor activities in the literatures. The network pharmacology and mechanism framework were employed in this study as powerful approaches to systematically analyze the complicated potential antitumor mechanisms and targets of GLPs in cancer. We then found that there are 69 targets and 21 network pathways in Pathways in cancer. Besides, we summarized the effects of GLPs and the models and methods used in the research of GLPs. In conclusion, GLPs have been studied extensively, but more in-depth research is still needed to determine the exact mechanisms and pathways. Therefore, this review might provide new insights into the vital targets and pathways for researchers to study the pharmacological mechanisms of GLPs for the treatment of diseases.
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