期刊
ALZHEIMERS & DEMENTIA
卷 18, 期 12, 页码 2527-2536出版社
WILEY
DOI: 10.1002/alz.12582
关键词
Alzheimer's disease; cognition; synaptic density; synaptic vesicle glycoprotein 2A; [C-11]UCB-J
资金
- National Institute on Aging [P30AG066508, P50AG047270, K23AG057784, R01AG052560, R01AG062276, RF1AG057553, P30AG021342]
- American Brain Foundation
- Dana Foundation
- Detre Fellowship Award in Translational Neuroscience Research in Psychiatry
- National Institute of Mental Health [T32MH019961]
- National Center for Advancing Translational Science [UL1TR000142]
This study examined the relationship between synaptic density and cognitive performance in early Alzheimer's disease patients using a new PET imaging technique. The results showed a significant positive correlation between synaptic density and cognitive performance, with synaptic density being a stronger predictor of cognitive ability.
Introduction For 30 years synapse loss has been referred to as the major pathological correlate of cognitive impairment in Alzheimer's disease (AD). However, this statement is based on remarkably few patients studied by autopsy or biopsy. With the recent advent of synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) imaging, we have begun to evaluate the consequences of synaptic alterations in vivo. Methods We examined the relationship between synaptic density measured by [C-11]UCB-J PET and neuropsychological test performance in 45 participants with early AD. Results Global synaptic density showed a significant positive association with global cognition and performance on five individual cognitive domains in participants with early AD. Synaptic density was a stronger predictor of cognitive performance than gray matter volume. Conclusion These results confirm neuropathologic studies demonstrating a significant association between synaptic density and cognitive performance, and suggest that this correlation extends to the early stages of AD.
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