期刊
ALZHEIMERS & DEMENTIA
卷 18, 期 12, 页码 2413-2427出版社
WILEY
DOI: 10.1002/alz.12547
关键词
dementia; falls; gait; mechanism; meta-analysis; mortality; motoric cognitive risk; pathophysiology; prevention; prognostic; review; subjective cognitive complaint
资金
- Masonic Charitable Foundation, United Kingdom
- Royal College of Psychiatrists, United Kingdom
- Age UK [MR/M01311/1]
- Biotechnology and Biological Sciences Research Council (BBSRC)
- University of Edinburgh
- Chief Scientist Office
- UKRI
- CSO
- NERC-MRC-CSO
- Alzheimer Scotland for Phase 2 of the Alzheimer Scotland Dementia Research Centre
- MRC
- Medical Research Council methodology board
- NIH
This study aimed to validate the predictive role of motoric cognitive risk (MCR) syndrome on the incidence of dementia and other major causes of morbidity in older adults. The findings showed that individuals with MCR were at an increased risk of cognitive impairment, dementia, falls, and mortality.
We aimed to refine the hypothesis that motoric cognitive risk (MCR), a syndrome combining measured slow gait speed and self-reported cognitive complaints, is prognostic of incident dementia and other major causes of morbidity in older age. We propose mechanisms on the relationship between motor and cognitive function and describe a roadmap to validate these hypotheses. We systematically searched major electronic databases from inception to August 2021 for original longitudinal cohort studies of adults aged >= 60 years that compared an MCR group to a non-MCR group with any health outcome. Fifteen cohorts were combined by meta-analysis. Participants with MCR were at an increased risk of cognitive impairment (adjusted hazard ratio [aHR] 1.76, 95% CI 1.49-2.08; I-2 = 24.9%), dementia (aHR 2.12, 1.85-2.42; 33.1%), falls (adjusted Relative Risk 1.38, 1.15-1.66; 62.1%), and mortality (aHR 1.49, 1.16-1.91; 79.2%). The prognostic value of MCR is considerable and mechanisms underlying the syndrome are proposed.
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