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A. Salehi et al.
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Jianhua Shi et al.
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M. S. Cheon et al.
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H. E. Lockstone et al.
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A. Nistor et al.
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Lucie Cabrejo et al.
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A. Coppus et al.
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A von Gunten et al.
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K Sambamurti et al.
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N Schupf et al.
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A Hirayama et al.
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DR Thal et al.
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C Mori et al.
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T Hassold et al.
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AM Cataldo et al.
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L Mucke et al.
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S Kumar-Singh et al.
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