期刊
ALLERGY
卷 77, 期 5, 页码 1464-1476出版社
WILEY
DOI: 10.1111/all.15170
关键词
allergic sensitization; infancy; PreventADALL; skin barrier
资金
- Regional Health Board South East
- Norwegian Research Council
- Oslo University Hospital
- University of Oslo
- Health and Rehabilitation Norway
- Foundation for Healthcare and Allergy Research in Sweden-Vardalstiftelsen
- Swedish Asthma and Allergy Association's Research Foundation
- Swedish Research Council-the Initiative for Clinical Therapy Research
- Swedish Heart-Lung Foundation
- SFO-V Karolinska Institute
- Ostfold Hospital Trust
- European Union (MeDALL project)
- Norwegian Asthma and Allergy Association
- Kloster Foundation
- Thermo Fisher, Uppsala, Sweden
- Furst Medical Laboratory, Oslo, Norway
- Norwegian Society of Dermatology and Venerology
- Arne Ingel's legat, Region Stockholm (ALF-project)
- FORTE
- Swedish Order of Freemasons Foundation Barnhuset
- Sven Jerring Foundation
- Hesselman Foundation
- Magnus Bergwall Foundation
- Konsul Th C Bergh's Foundation
- Swedish Society of Medicine
- King Gustaf V 80th Birthday Foundation
- Karolinska Institute grants
- Cancer and Allergy Foundation
- Pediatric Research Foundation at Astrid Lindgren Children's Hospital
- Samaritan Foundation for Pediatric Research
The study found that eczema, dry skin, and high TEWL at 3 months of age were associated with an increased risk of allergic sensitization at 6 months.
Background Factors predicting allergic sensitization in the first 6 months of life are poorly understood. We aimed to determine whether eczema, dry skin, and high transepidermal water loss (TEWL) at 3 months were associated with allergic sensitization at 6 months of age and, secondarily, to establish whether these characteristics predicted sensitization from 3 to 6 months of age. Methods At 3 months of age, 1,994 infants from the population-based PreventADALL birth cohort in Norway and Sweden were assessed for eczema and dry skin on the cheeks and/or extensors; impaired skin barrier function, defined as TEWL in the upper quartile (>9.4 g/m(2)/h), and allergen-specific IgE levels <0.1 kU(A)/L, available in 830. At 6 months, we assessed allergic sensitization to any food (egg, cow's milk, peanut, wheat, soy) or inhalant (birch, timothy grass, dog, and cat) allergen by a skin prick test wheal diameter >= 2 mm larger than negative control. Results Any sensitization was found in 198 of the 1,994 infants (9.9%), the majority to food allergens (n = 177, 8.9%). Eczema, dry skin, and high TEWL at 3 months increased the risk of sensitization at 6 months; adjusted odds ratios 4.20 (95% CI 2.93-6.04), 2.09 (95% CI 1.51-2.90) and 3.67 (95% CI 2.58-5.22), respectively. Eczema predicted sensitization with 55.6% sensitivity and 68.1% specificity; dry skin with 65.3% sensitivity and 57.3% specificity; and high TEWL with 61.7% sensitivity and 78.1% specificity. Conclusion Eczema, dry skin, and high TEWL at 3 months predicted allergic sensitization at 6 months of age.
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