期刊
AGEING RESEARCH REVIEWS
卷 71, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2021.101418
关键词
Hormesis; Metformin; Nrf2; Aging; Neuroprotection; AMPK
资金
- US Air Force [AFOSR FA9550-19-1-0413]
- ExxonMobil Foundation [S18200000000256]
- Startup Foundation for Introducing Talent of Nanjing University of Information Science & Technology (NUIST), Nanjing, China [003080]
Metformin induced hormetic biphasic dose responses across multiple organ systems and cell types, enhancing resilience to chemical stresses through an anti-inflammatory molecular network, thereby delaying the onset and progression of neurodegenerative and chronic diseases.
The present paper demonstrates that metformin (MF) induced a broad spectrum of hormetic biphasic dose responses in a wide range of experimental studies, affecting multiple organ systems, cell types, and endpoints enhancing resilience to chemical stresses in preconditioning and co-current exposure protocols. Detailed mechanistic evaluations indicate that MF-induced hormetic-adaptive responses are mediated often via the activation of adenosine monophosphate-activated kinase (AMPK) protein and its subsequent upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Hormesis-induced protective responses by MF are largely mediated via a vast and highly integrated anti-inflammatory molecular network that enhances longevity and delays the onset and slows the progression of neurodegenerative and other chronic diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据