期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 364, 期 3, 页码 518-524出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202101354
关键词
N-heterocyclic carbene; acyl azolium; photochemistry; potassium trifluoroborate; radical relay
资金
- Northwestern University
- National Institute of General Medical Sciences [R35GM136440]
The research presents a method for synthesizing gamma-aryloxyketones via combined NHC/photoredox catalysis, where an α-aryloxymethyl radical is coupled with styrene derivatives and then with an azolium radical to produce the desired products.
N-heterocyclic carbenes (NHCs) have emerged as catalysts for the construction of C-C bonds in the synthesis of substituted ketones under single-electron processes. Despite these recent reports, there still remains a need to increase the utility and practicality of these reactions by exploring new radical coupling partners. Herein, we report the synthesis of gamma-aryloxyketones via combined NHC/photoredox catalysis. In this reaction, an alpha-aryloxymethyl radical is generated via oxidation of an aryloxymethyl potassium trifluoroborate salt, which is then added into styrene derivatives to provide a stabilized benzylic radical. Subsequent radical-radical coupling reaction with an azolium radical affords the gamma-aryloxy ketone products.
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