期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 364, 期 2, 页码 302-306出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202101031
关键词
Dieckmann condensation; phosphonium salt catalysis; 1,3-dicarbonyl compounds
资金
- National Natural Science Foundation of China [21272247, 21572247, 21871282]
- Chinese Academy of Sciences [XDB 20020100]
An asymmetric Dieckmann condensation towards spirocyclic oxindoles and aza-oxindoles catalyzed by amino acid-derived phosphonium salt has been developed, which expands the applicability of asymmetric phosphonium salt catalysis in the production of 1,3-dicarbonyl compounds. The reaction features mild conditions, low catalyst loading, and a broad substrate scope. Control experiments confirmed the necessity of the catalyst's phosphonium skeleton and H-bonding site.
An asymmetric Dieckmann condensation towards spirocyclic oxindoles and aza-oxindoles catalyzed by amino acid-derived phosphonium salt has been developed, which expanded the applicability of asymmetric phosphonium salt catalysis in the production of 1,3-dicarbonyl compounds. This reaction is distinguished by its mild conditions (-20 degrees C), low catalyst loading (3-5 mol%), and broad substrate scope (25 examples). Control experiments revealed that both the catalyst's phosphonium skeleton and H-bonding site were required. Product transformations and a gram scale experiment were also carried out.
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