4.7 Article

Synthesis of Heterospirocycles through Gold-(I) Catalysis: Useful Building Blocks for Medicinal Chemistry

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Spirocyclic Scaffolds in Medicinal Chemistry

Kerstin Hiesinger et al.

Summary: Spirocyclic scaffolds are widely used in drugs, and the interest in nonplanar bioactive compounds is growing. This article summarizes different synthetic routes to obtain spirocyclic systems, discussing their impact on potency and selectivity, as well as changes in physicochemical properties and ADME in vitro and in vivo.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Pharmacology & Pharmacy

Fsp(3): A new parameter for drug-likeness

Wenxiu Wei et al.

DRUG DISCOVERY TODAY (2020)

Article Chemistry, Multidisciplinary

An Apparent Umpolung Reactivity of Indole through [Au]-Catalysed Cyclisation and Lewis-Acid-Mediated Allylation

Mahesh H. Shinde et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Article Chemistry, Medicinal

Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon

Tanaji T. Talele

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Ketones and Aldehydes as O-Nucleophiles in Iridium-Catalyzed Intramolecular Asymmetric Allylic Substitution Reaction

Ye Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Organic

Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection

Attila Sveiczer et al.

ORGANIC LETTERS (2019)

Article Biochemistry & Molecular Biology

Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery

Gemma C. Geary et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery

Alexander A. Kirichok et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

Review Pharmacology & Pharmacy

The hitchhiker's guide to the chemical-biological galaxy

Giulia Opassi et al.

DRUG DISCOVERY TODAY (2018)

Article Chemistry, Multidisciplinary

Charting Biologically Relevant Spirocyclic Compound Space

Gerhard Mueller et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

Editorial Material Pharmacology & Pharmacy

The utilization of spirocyclic scaffolds in novel drug discovery

Ya-Jun Zheng et al.

EXPERT OPINION ON DRUG DISCOVERY (2016)

Article Chemistry, Multidisciplinary

Regioselectivity in the Au-catalyzed hydration and hydroalkoxylation of alkynes

Justin A. Goodwin et al.

CHEMICAL COMMUNICATIONS (2015)

Article Chemistry, Medicinal

The use of spirocyclic scaffolds in drug discovery

Yajun Zheng et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Review Chemistry, Multidisciplinary

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

Erick M. Carreira et al.

CHEMICAL REVIEWS (2014)

Article Chemistry, Organic

Synthesis of a Family of Spirocyclic Scaffolds: Building Blocks for the Exploration of Chemical Space

Sarvesh Kumar et al.

JOURNAL OF ORGANIC CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Escape from Flatland 2: complexity and promiscuity

Frank Lovering

MEDCHEMCOMM (2013)

Review Biochemistry & Molecular Biology

Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database

Jean-Louis Reymond et al.

ACS CHEMICAL NEUROSCIENCE (2012)

Review Chemistry, Organic

Gold-catalyzed heterocyclizations in alkynyl- and allenyl-β-lactams

Benito Alcaide et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2011)

Article Chemistry, Organic

Cationic Gold(I)-Catalyzed Intramolecular Cyclization of γ-Hydroxyalkynones into 3(2H)-Furanones

Masahiro Egi et al.

JOURNAL OF ORGANIC CHEMISTRY (2010)

Article Chemistry, Multidisciplinary

Diversity-Oriented Synthesis of Morpholine-Containing Molecular Scaffolds

Claudia Lalli et al.

CHEMISTRY-A EUROPEAN JOURNAL (2009)

Article Chemistry, Medicinal

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Chemistry, Applied

One-pot synthesis of 5-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Ramanaiah C. Kanamarlapudi et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2007)

Article Multidisciplinary Sciences

Chemical space and biology

CM Dobson

NATURE (2004)

Article Chemistry, Organic

Utilization of lithium triethylborohydride as a selective N-acyl deprotecting agent

H Tanaka et al.

TETRAHEDRON LETTERS (2002)