期刊
ADVANCED MATERIALS
卷 34, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202107192
关键词
click chemistry; drug delivery; hydrogels; imaging probe; metabolic glycoengineering; nanoparticles
类别
资金
- Basic Research Program through the National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT, and Future Planning) [2021R1F1A1061286, 2021R1A4A3031875]
- Mid-Career Researcher Program through National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT, and Future Planning) [NRF2019R1A2C3006283]
- KU-KIST Graduate School of Converging Science and Technology (Korea University)
- National Research Foundation of Korea [2021R1F1A1061286, 2019R1A2C3006283, 2021R1A4A3031875] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Traditional organic chemical reactions often require organic solvents, toxic catalysts, heat, or high pressure. However, copper-free click chemistry offers a more favorable alternative with its fast reaction rates and orthogonality in water, buffer solutions, and physiological conditions without the need for toxic catalysts. This has led to its growing interest in biomedical research, where it has been used in various applications such as molecular imaging and therapy.
Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or high pressure. However, copper-free click chemistry has been shown to have favorable reaction rates and orthogonality in water, buffer solutions, and physiological conditions without toxic catalysts. Strain-promoted azide-alkyne cycloaddition and inverse electron-demand Diels-Alder reactions are representative of copper-free click chemistry. Artificial chemical reactions via click chemistry can also be used outside of the laboratory in a controllable manner on live cell surfaces, in the cytosol, and in living bodies. Consequently, copper-free click chemistry has many features that are of interest in biomedical research, and various new materials and strategies for its use have been proposed. Herein, recent remarkable trials that have used copper-free click chemistry are described, focusing on their applications in molecular imaging and therapy. The research is categorized as nanoparticles for drug delivery, imaging agents for cell tracking, and hydrogels for tissue engineering, which are rapidly advancing fields based on click chemistry. The content is based primarily on the experience with click chemistry-based biomaterials over the last 10 years.
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