期刊
ADVANCED MATERIALS
卷 34, 期 46, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202107406
关键词
biological membranes; biomedical materials; biomimetic membranes; drug delivery; tissue engineering
类别
资金
- National Natural Science Foundation of China [52173140, 51925304, 51803173]
- Sichuan Province Science and Technology [2021YJ192]
- Opening Project of State Key Laboratory of Polymer Materials Engineering (Sichuan University) [sklpme2020-4-13]
The delicate structure and fantastic functions of biological membranes have been utilized to construct multifunctional biomedical materials. These materials show excellent properties, such as long circulation time, disease-targeted therapy, excellent biocompatibility, and selective recognition. However, there are challenges associated with the clinical applications of biological-membrane derived materials.
The delicate structure and fantastic functions of biological membranes are the successful evolutionary results of a long-term natural selection process. Their excellent biocompatibility and biofunctionality are widely utilized to construct multifunctional biomedical materials mainly by directly camouflaging materials with single or mixed biological membranes, decorating or incorporating materials with membrane-derived vesicles (e.g., exosomes), and designing multifunctional materials with the structure/functions of biological membranes. Here, the structure-function relationship of some important biological membranes and biomimetic membranes are discussed, such as various cell membranes, extracellular vesicles, and membranes from bacteria and organelles. Selected literature examples of multifunctional biomaterials derived from biological membranes for biomedical applications, such as drug- and gene- delivery systems, tissue- repair scaffolds, bioimaging, biosensors, and biological detection, are also highlighted. These designed materials show excellent properties, such as long circulation time, disease-targeted therapy, excellent biocompatibility, and selective recognition. Finally, perspectives and challenges associated with the clinical applications of biological-membranederived materials are discussed.
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