期刊
ADVANCED MATERIALS
卷 34, 期 8, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202106654
关键词
immunotherapy; organic nanoparticles; photodynamic therapy; precision nanomedicines
类别
资金
- Singapore Ministry of Education [2019-T1-002-045, RG125/19, MOE2018-T2-2-042]
- A*STAR SERC AME Programmatic Fund [SERC A18A8b0059]
- National Key R&D Program of China [2017YFA0205600]
- National Natural Science Foundation of China [51633008, 32071378, 31870996]
- Science and Technology Program of Guangzhou [202103030004]
- Guangdong Provincial Pearl River Talents Program [2017GC010713, 2017GC010482]
- China Postdoctoral Science Foundation [2021M701235]
- Natural Science Foundation of Guangdong Province, China [2021A1515010592]
This study reports a smart semiconducting polymer nano-immunomodulator that can achieve precise regulation of photodynamic immunotherapy for cancer in the acidic tumor microenvironment. The release of immunogenic factors and TLR7 agonist at the tumor site activates dendritic cells, leading to strong antitumor activities. Additionally, the nano-immunomodulator can directly eradicate tumors and induce immunogenic cancer cell death. This approach enhances systemic antitumor immune responses, resulting in inhibition of tumor growth and metastasis.
Cancer nanomedicine combined with immunotherapy has become a promising strategy for treating cancer in terms of safety and potency; however, precise regulation of the activation of antitumor immunity remains challenging. Herein, a smart semiconducting polymer nano-immunomodulator (SPNI), which responds to the acidic tumor microenvironment (TME), for precision photodynamic immunotherapy of cancer, is reported. The SPNI is self-assembled by a near-infrared (NIR)-absorbing semiconducting polymer and an amphipathic polymer conjugated with a Toll-like receptor 7 (TLR7) agonist via an acid-labile linker. Upon arrival at tumor site, SPNI undergoes hydrolysis and triggers an efficient liberation of TLR7 agonist in response to the acidic TME for dendritic cell activation. Moreover, SPNI exerts photodynamic effects for direct tumor eradication and immunogenic cancer cell death under NIR photoirradiation. The synergistic action of released immunogenic factors and acidic-TME-activated TLR7 agonist can serve as an in situ generated cancer vaccine to evoke strong antitumor activities. Notably, such localized immune activation boosts systemic antitumor immune responses, resulting in enhanced cytotoxic CD8(+) T infiltration to inhibit tumor growth and metastasis. Thereby, this work presents a general strategy to devise prodrug of immunotherapeutics for precise regulation of cancer immunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据