A Biomimetic Human Lung-on-a-Chip with Colorful Display of Microphysiological Breath

Lung-on-a-chip models hold great promise for disease modeling and drug screening. Herein, inspired by the iridescence phenomenon of soap bubbles, a novel biomimetic 3D microphysiological lung-on-a-chip system with breathing visualization is presented. The system, with an array of pulmonary alveoli at the physiological scale, is constructed and coated with structural color materials. Cyclic deformation is induced by regular airflow, resembling the expansion and contraction of the alveoli during rhythmic breathing. As the deformation is accompanied with corresponding synchronous shifts in the structural color, the constructed system offers self-reporting of the cell mechanics and enables real-time monitoring of the cultivation process. Using this system, the dynamic relationships between the color atlas and disease symptoms, showing the essential role of mechanical stretching in the phenotypes of idiopathic pulmonary fibrosis, are investigated. These features make this human lung system ideal in biological study, disease monitoring, and drug discovery.

Automated summary

In this study, a novel biomimetic 3D microphysiological lung-on-a-chip system with breathing visualization was developed. The system, inspired by the iridescence phenomenon of soap bubbles, allows for the cyclic deformation of pulmonary alveoli and real-time monitoring of cell mechanics. The research also reveals the essential role of mechanical stretching in idiopathic pulmonary fibrosis.