4.8 Article

PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart

Imran Ozer et al.

Summary: Protein therapeutics, especially those with PEG decoration, face challenges of short half-life and immunogenicity. The authors developed a poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) conjugate to improve the stability and immunogenicity of PEGylated proteins. The uricase-POEGMA conjugate demonstrated enhanced pharmacokinetics and reduced immunogenicity compared to traditional PEGylated proteins.

ADVANCED SCIENCE (2022)

Letter Anesthesiology

Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?

Lene H. Garvey et al.

BRITISH JOURNAL OF ANAESTHESIA (2021)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Medicine, General & Internal

Maintaining Safety with SARS-CoV-2 Vaccines

Mariana C. Castells et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Biology

Recent Progress and Opportunities for Nucleic Acid Aptamers

Jonghoe Byun

Summary: Aptamers, short nucleic acid sequences capable of specific molecular binding, have shown significant potential in therapeutics and diagnostics. Despite challenges in clinical trials, novel technologies and advancements are fueling hope in the field of aptamers.

LIFE-BASEL (2021)

Review Chemistry, Multidisciplinary

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

Bing-Mae Chen et al.

Summary: The article discusses the application of polyethylene glycol (PEG) in drugs and nanoparticles, as well as the potential immunogenicity issues it may cause. Research reveals rules for predicting rapid clearance of drugs and liposomes, and experimental studies on anti-PEG antibody binding to different forms and sizes of PEG are provided.

ACS NANO (2021)

Review Nanoscience & Nanotechnology

The current landscape of nucleic acid therapeutics

Jayesh A. Kulkarni et al.

Summary: The increasing number of approved nucleic acid therapeutics demonstrates their potential for long-lasting or curative effects by targeting genetic blueprints; however, their clinical translation relies on advances in delivery technologies. Four platform technologies, including antisense oligonucleotides, small interfering RNA conjugates, lipid nanoparticles, and adeno-associated virus vectors, have enabled the clinical translation of nucleic acid therapeutics, leading to the approval of cutting-edge genetic drugs.

NATURE NANOTECHNOLOGY (2021)

Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Biotechnology & Applied Microbiology

Therapeutic strategies for thrombosis: new targets and approaches

Nigel Mackman et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Cardiac & Cardiovascular Systems

Management of Antithrombotic Agents During Surgery or Other Kinds of Medical Procedures With Bleeding: The MARK Study

Seiji Gotoh et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

Editorial Material Biotechnology & Applied Microbiology

RNA therapeutics on the rise

Feng Wang et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Pharmacology & Pharmacy

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

Gergely Tibor Kozma et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Biotechnology & Applied Microbiology

Advances in oligonucleotide drug delivery

Thomas C. Roberts et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Pharmacology & Pharmacy

Paving the Road for RNA Therapeutics

Niels Dammes et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Materials Science, Multidisciplinary

PEGylated liposomes: immunological responses

Marwa Mohamed et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2019)

Article Biochemistry & Molecular Biology

Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers

Angelo Moreno et al.

CELL CHEMICAL BIOLOGY (2019)

Review Clinical Neurology

Antisense oligonucleotides: the next frontier for treatment of neurological disorders

Carlo Rinaldi et al.

NATURE REVIEWS NEUROLOGY (2018)

Review Biotechnology & Applied Microbiology

Aptamers as targeted therapeutics: current potential and challenges

Jiehua Zhou et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Multidisciplinary Sciences

Computational design of small transcription activating RNAs for versatile and dynamic gene regulation

James Chappell et al.

NATURE COMMUNICATIONS (2017)

Review Genetics & Heredity

Advances in the delivery of RNA therapeutics: from concept to clinical reality

James C. Kaczmarek et al.

GENOME MEDICINE (2017)

Article Biochemistry & Molecular Biology

Effect of Molecular Architecture on Cell Interactions and Stealth Properties of PEG

Imran Ozer et al.

BIOMACROMOLECULES (2017)

Review Biochemical Research Methods

Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins

Imran Ozer et al.

BIOCONJUGATE CHEMISTRY (2017)

Review Medicine, Research & Experimental

From selection hits to clinical leads: progress in aptamer discovery

Keith E. Maier et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2016)

Review Hematology

Modulation of the Coagulation Cascade Using Aptamers

Rebecca S. Woodruff et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Creating small transcription activating RNAs

James Chappell et al.

NATURE CHEMICAL BIOLOGY (2015)

Review Nanoscience & Nanotechnology

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

Qi Yang et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2015)

Review Pharmacology & Pharmacy

Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics

Johan J. F. Verhoef et al.

DRUG DISCOVERY TODAY (2014)

Article Biochemistry & Molecular Biology

Shape matters: size-exclusion HPLC for the study of nucleic acid structural polymorphism

Eric Largy et al.

NUCLEIC ACIDS RESEARCH (2014)

Editorial Material Pharmacology & Pharmacy

Immunogenicity of Subcutaneously Administered Therapeutic Proteins-a Mechanistic Perspective

Anas M. Fathallah et al.

AAPS JOURNAL (2013)

Review Pharmacology & Pharmacy

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

Wolfgang F. Richter et al.

AAPS JOURNAL (2012)

Editorial Material Pharmacology & Pharmacy

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

Ricardo P. Garay et al.

EXPERT OPINION ON DRUG DELIVERY (2012)

Article Polymer Science

Aqueous ARGET ATRP

Antonina Simakova et al.

MACROMOLECULES (2012)

Article Cell Biology

Aptamers and the RNA World, Past and Present

Larry Gold et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Review Chemistry, Medicinal

Delivery of Therapeutic Proteins

Dipak S. Pisal et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

Review Biotechnology & Applied Microbiology

Aptamers as therapeutics

Anthony D. Keefe et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Biotechnology & Applied Microbiology

Antidote-mediated control of an anticoagulant aptamer in vivo

CP Rusconi et al.

NATURE BIOTECHNOLOGY (2004)

Review Pharmacology & Pharmacy

Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates

P Caliceti et al.

ADVANCED DRUG DELIVERY REVIEWS (2003)

Review Genetics & Heredity

Gene silencing in mammals by small interfering RNAs

MT McManus et al.

NATURE REVIEWS GENETICS (2002)

Article Multidisciplinary Sciences

RNA aptamers as reversible antagonists of coagulation factor IXa

CP Rusconi et al.

NATURE (2002)