期刊
ADVANCED MATERIALS
卷 33, 期 48, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202105667
关键词
hydrogels; o-nitrobenzyl photocages; oral mucosal diseases; photo-crosslinking; tissue adhesives
类别
资金
- National Key Research and Development Program of China [2019YFA0110500, 2016YFC1102900, 2019YFA0904800]
- National Natural Science Foundation of China [81921002, 82022015, 32071361, 22022506, 81991505, 21937004]
- Shanghai Rising-Star Program [20QA1405700]
- Shanghai Jiao Tong University, School of Medicine [SH9H-2019-A167-1]
The wet and dynamic environment of the mouth poses challenges for local treatment of oral mucosal diseases, but a newly developed photo-crosslinking hydrogel adhesive shows promise in creating a favorable microenvironment for tissue repair and shortening healing time.
The wet and highly dynamic environment of the mouth makes local treatment of oral mucosal diseases challenging. To overcome this, a photo-crosslinking hydrogel adhesive is developed inspired by the success of light-curing techniques in dentistry. The adhesive operates on a fast (within 5 s) phototriggered S-nitrosylation coupling reaction and employs imine anchoring to connect to host tissues. Unlike other often-used clinical agents that adhere weakly and for short durations, this thin, elastic, adhesive, and degradable cyclic o-nitrobenzyl-modified hyaluronic acid gel protects mucosal wounds from disturbance by liquid rinsing, oral movement, and friction for more than 24 h. The results from both rat and pig oral mucosa repair models demonstrate that this new gel adhesive creates a favorable microenvironment for tissue repair and can shorten tissue healing time. This study thus illustrates a therapeutic strategy with the potential to advance the treatment of oral mucosal defects in the clinic.
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