4.8 Review

Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

期刊

ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 12, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202111003

关键词

biomaterials; macrophage polarization; tissue regeneration; wound healing; wound microenvironment

资金

  1. National Key Research and Development Program of China [2020YFA0908200]
  2. National Natural Science Foundation of China [81930051, 81801928, 32000937, 81772099]
  3. Shanghai Municipal Health Commission [20204Y0354]
  4. China Postdoctoral Science Foundation [2020M681321]
  5. Shanghai Jiao Tong University Medical and Research Program [ZH2018ZDA04]
  6. Young Physician Innovation Team Project from Ninth People's Hospital [QC201902]
  7. Shanghai Jiao Tong University Young Physician Innovation Team Project from Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine [QC201902]
  8. Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20171906]

向作者/读者索取更多资源

The review discusses the use of macrophage immunotherapy in promoting wound healing, as well as the importance of biomaterials in regulating macrophage signaling for tissue regeneration.
Macrophage immunotherapy is an emerging treatment strategy that modulates the immune system to promote wound healing. The functionality and regeneration of tissue depend on spatially and temporally regulating the biophysical and biochemical microenvironmental with poorly understood mechanisms. Biomaterials are carefully crafted to display and deliver macrophage regulatory signals in a precise and near-physiological way, serving as powerful artificial microenvironments in which to explore and direct the fate of macrophages. The review starts with discussing the classification and function of macrophages, and then introduces the polarization of macrophages in different microenvironments of conventional wounds and chronic wounds. Recent advances in biomaterials that balance the phenotypes of macrophages in wound healing are emphasized. Finally, looking ahead, the potential ability of biomaterial scaffolds to modulate immune signaling to produce an environment conducive to regeneration is discussed.

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