4.8 Review

Recent Advances in Nanozymes: From Matters to Bioapplications

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Ligand-Dependent Activity Engineering of Glutathione Peroxidase-Mimicking MIL-47(V) Metal-Organic Framework Nanozyme for Therapy

Jiangjiexing Wu et al.

Summary: A ligand engineering strategy was developed to modulate the GPx-mimicking activity of a metal-organic framework (MOF) nanozyme, resulting in the rational regulation of the GPx-mimicking activities of MIL-47(V)-X MOFs. Among them, MIL-47(V)-NH2 demonstrated excellent antioxidation ability, effectively alleviating inflammatory responses in both ear injury and colitis models. This study proves the feasibility of designing high-performance GPx-mimicking nanozymes and highlights the importance of structure-activity relationships in directing in vivo therapy.

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Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers

Yue Zhang et al.

Summary: Integrating protein reconstruction technology and nanotechnology, an artificial hybrid nanozyme with superoxide dismutase and catalase-like activities was developed to target mitochondria and demonstrate protective effects in mitochondrial oxidative injury and heart function recovery. This innovative approach highlights the potential of enzyme mimics in regenerative medicine for alleviating oxidative damage.

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Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation

Yongjian Ai et al.

Summary: The study introduces a highly efficient nanozyme, Se@Me@MnO2, that demonstrates potential for intracellular antioxidation and anti-inflammation by scavenging ROS through multiple enzyme activities. The nanozyme shows promise for treating inflammatory diseases due to its ability to quickly clear hydrogen peroxide, hydroxyl radical, and superoxide anion through synergistic and fast electron transfer effects.

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Nanozyme scavenging ROS for prevention of pathologic α-synuclein transmission in Parkinson's disease

Yu-Qing Liu et al.

Summary: Braak's prion-like theory challenges the conventional understanding of Parkinson's disease, while the use of nanomaterials like nanozyme to inhibit the spreading of alpha-synuclein shows potential as a therapeutic strategy against PD and other prion-like proteinopathies.

NANO TODAY (2021)

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Efficient Combination of G-C3N4 and CDs for Enhanced Photocatalytic Performance: A Review of Synthesis, Strategies, and Applications

Lin Ai et al.

Summary: This review focuses on the potential applications of heterogeneous photocatalysts composed of g-C3N4 and CDs in resolving tough energy and environmental issues through an ecologically sustainable manner. It discusses various synthetic methods, strategies for enhanced performance, and applications in hydrogen generation, carbon dioxide reduction, and organic pollutants degradation, providing guidance for further powerful combination of g-C3N4 and CDs in photocatalysis.
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Coordination Number Regulation of Molybdenum Single-Atom Nanozyme Peroxidase-like Specificity

Ying Wang et al.

Summary: Researchers have reported on the theoretical design and experimental realization of heterogeneous molybdenum single-atom nanozymes, showing that the coordination number can regulate the peroxidase-like specificity and allow for precise control of their enzymatic properties.
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Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

Xuantong Zhou et al.

Summary: Radioresistance poses a significant challenge in clinical treatments, attributed to factors such as hypoxia in the tumor microenvironment, antioxidant systems in cancer cells, and upregulation of DNA repair proteins. A novel strategy involving GDY-CeO2 nanocomposites and miR181a shows promise in overcoming radioresistance and enhancing therapeutic efficacy in ESCC patients by mitigating hypoxia, promoting DNA damage, and facilitating personalized treatment.

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In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

Lufeng Zhang et al.

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Matching the kinetics of natural enzymes with a single-atom iron nanozyme

Shufang Ji et al.

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Dual Enzyme Mimics Based on Metal-Ligand Cross-Linking Strategy for Accelerating Ascorbate Oxidation and Enhancing Tumor Therapy

Yongjian Ai et al.

Summary: The development of high-efficiency nanozymes with excellent oxidase-like and peroxidase-like enzyme activities is significant for enhancing the oxidation of ascorbate to improve cancer cell ablation efficacy. The fabricated nanozyme can rapidly and completely oxidize ascorbate within 20 minutes, leading to tumor cell death through the generation of superoxide free radicals and hydrogen peroxide.Overall, the research shows a promising enhancement in anti-tumor efficacy through ascorbate oxidation catalyzed by the developed nanozyme.

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Modular Assembly of Tumor-Penetrating and Oligomeric Nanozyme Based on Intrinsically Self-Assembling Protein Nanocages

Qiqi Liu et al.

Summary: This study introduces a synthetic biology strategy using nanomaterials to accurately tailor high-ordered nanostructures through hierarchical incorporation of protein building blocks. The assembled nano-oligomers possess tunable protein motifs and multivalent binding domains, showing promising therapeutic and anti-tumor effects. Additionally, the creation of artificial nanozymes with peroxidase-like activity and cytotoxic free radical generation further enhances the therapeutic benefits of systemic delivery compared to nanozymes alone.

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Zero-Dimensional/Two-Dimensional AuxPd100-x Nanocomposites with Enhanced Nanozyme Catalysis for Sensitive Glucose Detection

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Co-Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

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Highly Selective Fluorescent Sensing of Phosphite through Recovery of Poisoned Nickel Oxide Nanozyme

Yangyang Chang et al.

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An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

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Two-Dimensional Tin Selenide (SnSe) Nanosheets Capable of Mimicking Key Dehydrogenases in Cellular Metabolism

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Au nanozyme-driven antioxidation for preventing frailty

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Ultrasonic synthesis of nano-PrO1.8 as nanozyme for colorimetric determination of trans-resveratrol

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Self-limited Phosphatase-mimicking CeO2 Nanozymes

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Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

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An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy

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Fe-N-C Single-Atom Nanozymes for the Intracellular Hydrogen Peroxide Detection

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Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma

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Defect-Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition

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Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy

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A Multinuclear Metal Complex Based DNase-Mimetic Artificial Enzyme: Matrix Cleavage for Combating Bacterial Biofilms

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Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System

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Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

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