Injectable Double-Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment

Article Engineering, Environmental

Injectable stretchable self-healing dual dynamic network hydrogel as adhesive anti-oxidant wound dressing for photothermal clearance of bacteria and promoting wound healing of MRSA infected motion wounds

Meng Li et al.

Summary: Researchers have developed an injectable adhesive self-healing photothermal hydrogel that can adapt to frequent movement wounds and promote healing, while also preventing and treating wound infections.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Injectable Self-Healing Natural Biopolymer-Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

Lei Zhou et al.

Summary: An injectable self-healing biocompatible hydrogel adhesive has been developed, based on gelatin and chondroitin sulfate, allowing for strong tissue adhesion at physiological temperatures which can be easily detached at low temperatures. This adhesive is effective in sealing and reconnecting tissues, making it suitable for minimally invasive surgical applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Injectable Self-Healing Hydrogel Wound Dressing with Cysteine-Specific On-Demand Dissolution Property Based on Tandem Dynamic Covalent Bonds

Xiaoya Ding et al.

Summary: An injectable self-healing hydrogel with rapid gelation and cysteine-specific on-demand dissolution was designed for wound dressings, showing excellent injectability, self-healing ability, and rapid cysteine-triggered dissolution. The hydrogel displayed favorable biocompatibility, achieved rapid wound closure in seconds, and fast on-demand dissolution for dressing changes, highlighting its potential for wound healing applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Smart wound dressings for wound healing

Ruonan Dong et al.

Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.

NANO TODAY (2021)

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Review Chemistry, Multidisciplinary

Tissue adhesives: From research to clinical translation

Ayca Bal-Ozturk et al.

Summary: Tissue adhesives serve as an interface to connect the surfaces of wound edges and prevent them from separation, offering new possibilities for wound closure. The chemical properties of these products play a crucial role in their commercial success in clinical applications.

NANO TODAY (2021)

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Article Multidisciplinary Sciences

Fracture, fatigue, and friction of polymers in which entanglements greatly outnumber cross-links

Junsoo Kim et al.

Summary: By synthesizing polymers with a large number of entanglements and sparse cross-links, high toughness, strength, and fatigue resistance can be achieved, resulting in hydrogels with low hysteresis, low friction, and high wear resistance after swelling in water.

SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

Jiahui He et al.

Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.

NANO-MICRO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

Zifeng Yang et al.

Summary: By grafting cationic polyelectrolyte brushes onto polydopamine/polyacrylamide hydrogels, the mechanical and antibacterial properties of the hydrogels were enhanced, leading to stable coverage, long-lasting antibacterial effects, and fast wound healing.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing

Yuqing Liang et al.

Summary: The research developed a smart bioadhesive hydrogel sealant with self-healing and excellent antibacterial activity, showing high effectiveness in wound closure and post-wound-closure care. The hydrogel features autonomous healing, on-demand dissolution, injectability, good biocompatibility, antibacterial properties, multifunctional adhesiveness, and NIR responsiveness. In vivo evaluation demonstrated the great potential of the smart hydrogel in dealing with skin incisions and infected full-thickness skin wounds.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Multifaceted Design and Emerging Applications of Tissue Adhesives

Zhenwei Ma et al.

Summary: Tissue adhesives have a wide range of applications and numerous advantages, and are currently in a phase of rapid development. The key elements of their design have been comprehensively discussed, while opportunities for improvement and further development have also been suggested.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties

Xuanhe Zhao et al.

Summary: Hydrogels possess extreme mechanical properties and have diverse applications. While many hydrogels have been developed, a set of general principles for designing them for various applications remains a central need.

CHEMICAL REVIEWS (2021)

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Article Materials Science, Multidisciplinary

A universal method to easily design tough and stretchable hydrogels

Chisa Norioka et al.

Summary: This paper presents a universal strategy for preparing tough and stretchable hydrogels by adjusting polymerization conditions to increase polymer chain entanglements for energy dissipation. The balance between physical and chemical cross-links is optimized by utilizing entanglements and covalent bonds, respectively, leading to improved mechanical performance of hydrogels for wide practical use.

NPG ASIA MATERIALS (2021)

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Article Multidisciplinary Sciences

Coagulopathy-independent, bioinspired hemostatic materials: A full research story from preclinical models to a human clinical trial

Keumyeon Kim et al.

Summary: This study reports a sticky polysaccharide that effectively promotes hemostasis by rapidly forming a barrier layer to seal hemorrhaging sites. This technology has been successfully applied in animal models and human hepatectomy procedures.

SCIENCE ADVANCES (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Article Multidisciplinary Sciences

Hydrogel-mesh composite for wound closure

Yang Gao et al.

Summary: Surgical mesh is commonly fixed on tissues through fasteners, but may cause stress concentration and tissue damage. Hydrogel-mesh composites (HMCs) retain attributes of surgical mesh and add tissue adhesion capability. By soaking a surgical mesh with a precursor that forms a polymer network upon cure, HMCs can form covalent bonds with tissues, distributing force over a large area.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Ultrahigh energy-dissipation elastomers by precisely tailoring the relaxation of confined polymer fluids

Jin Huang et al.

Summary: By constructing polymer-fluid-gels, this study achieves controllable ultra-high energy dissipation over a wide frequency range, which is more effective than traditional methods.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

Xin Peng et al.

Summary: The PEI/PAA powder demonstrates strong wet adhesion by forming a physically cross-linked hydrogel on wet tissues, making it suitable for various biomedical applications.

SCIENCE ADVANCES (2021)

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Article Chemistry, Multidisciplinary

Recapitulation of In Situ Endochondral Ossification Using an Injectable Hypoxia-Mimetic Hydrogel

Lili Sun et al.

Summary: An injectable hydrogel has been developed to mimic hypoxia and replicate endochondral ossification through iron chelation, promoting bone regeneration.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Hydrogel Adhesion: A Supramolecular Synergy of Chemistry, Topology, and Mechanics

Jiawei Yang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Novel Double-Crosslinking-Double-Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

Lei Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Physical Double-Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self-Healing, Antioxidant and NIR/pH Stimulus-Responsiveness for Multidrug-Resistant Bacterial Infection and Removable Wound Dressing

Xin Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Nanoscience & Nanotechnology

Overcoming the translational barriers of tissue adhesives

Gonzalo Munoz Taboada et al.

NATURE REVIEWS MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Rapid Fabrication of Self-Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body

Sixiang Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Liquid Bandage Harvests Robust Adhesive, Hemostatic, and Antibacterial Performances as a First-Aid Tissue Adhesive

Yufei Ma et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Hooyeon Jung et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

Flavia Castro et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

A viscoelastic PEGylated poly(glycerol sebacate)-based bilayer scaffold for cartilage regeneration in full-thickness osteochondral defect

Dan Lin et al.

BIOMATERIALS (2020)

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Article Physics, Condensed Matter

Polyelectrolyte Complex Coacervates: Recent Developments and New Frontiers

Artem M. Rumyantsev et al.

Annual Review of Condensed Matter Physics (2020)

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Article Chemistry, Multidisciplinary

Stretchable, self-healing and tissue-adhesive zwitterionic hydrogels as strain sensors for wireless monitoring of organ motions

Xinjie Pei et al.

MATERIALS HORIZONS (2020)

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Review Chemistry, Multidisciplinary

Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications

Wei Zhang et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Review Chemistry, Multidisciplinary

The Chemistry behind Catechol-Based Adhesion

J. Saiz-Poseu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

Tetra-PEG Based Hydrogel Sealants for In Vivo Visceral Hemostasis

Yazhong Bu et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Thermoresponsive Complex Coacervate-Based Underwater Adhesive

Marco Dompe et al.

ADVANCED MATERIALS (2019)

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Review Engineering, Biomedical

Multifunctional Biomedical Adhesives

Rattapol Pinnaratip et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Multidisciplinary Sciences

Bioinspired mechanically active adhesive dressings to accelerate wound closure

S. O. Blacklow et al.

SCIENCE ADVANCES (2019)

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Article Chemistry, Multidisciplinary

Tissue Tapes-Phenolic Hyaluronic Acid Hydrogel Patches for Off-the-Shelf Therapy

Jisoo Shin et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Review Engineering, Biomedical

Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances

Dimple Chouhan et al.

BIOMATERIALS (2019)

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Article Nanoscience & Nanotechnology

Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction

Zhize Yuan et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Multidisciplinary Sciences

Dry double-sided tape for adhesion of wet tissues and devices

Hyunwoo Yuk et al.

NATURE (2019)

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Article Chemistry, Multidisciplinary

Multipurpose Intraperitoneal Adhesive Patches

Ji Hyun Ryu et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Review Pharmacology & Pharmacy

Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair

Timothy J. Keane et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Review Chemistry, Multidisciplinary

Bioinspired Underwater Adhesives by Using the Supramolecular Toolbox

Anton H. Hofman et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Applied

Preparation of the chitosan/poly(glutamic acid)/alginate polyelectrolyte complexing hydrogel and study on its drug releasing property

Yu Chen et al.

CARBOHYDRATE POLYMERS (2018)

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Review Surgery

The Implications of Barbed Sutures on Scar Aesthetics: A Systematic Review

Catherine C. Motosko et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2018)

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Article Engineering, Biomedical

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

Jin Qu et al.

BIOMATERIALS (2018)

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Review Immunology

The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis

Teruki Dainichi et al.

NATURE IMMUNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Ascidian-Inspired Fast-Forming Hydrogel System for Versatile Biomedical Applications: Pyrogallol Chemistry for Dual Modes of Crosslinking Mechanism

Jung Ho Cho et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Mussel-Inspired Adhesive and Conductive Hydrogel with Long-Lasting Moisture and Extreme Temperature Tolerance

Lu Han et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Review Chemistry, Multidisciplinary

Perspectives on Mussel-Inspired Wet Adhesion

B. Kollbe Ahn

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Multidisciplinary Sciences

Tough adhesives for diverse wet surfaces

J. Li et al.

SCIENCE (2017)

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Review Chemistry, Multidisciplinary

Spatiotemporal hydrogel biomaterials for regenerative medicine

Tobin E. Brown et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Chemistry, Physical

Tough bonding of hydrogels to diverse non-porous surfaces

Hyunwoo Yuk et al.

NATURE MATERIALS (2016)

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Review Chemistry, Multidisciplinary

Supramolecular polymer adhesives: advanced materials inspired by nature

Christian Heinzmann et al.

CHEMICAL SOCIETY REVIEWS (2016)

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Article Chemistry, Physical

Underwater contact adhesion and microarchitecture in polyelectrolyte complexes actuated by solvent exchange

Qiang Zhao et al.

NATURE MATERIALS (2016)

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Article Chemistry, Multidisciplinary

Self-Adjustable Adhesion of Polyampholyte Hydrogels

Chanchal Kumar Roy et al.

ADVANCED MATERIALS (2015)

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Review Chemistry, Multidisciplinary

The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial

C. Ghobril et al.

CHEMICAL SOCIETY REVIEWS (2015)

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Article Engineering, Biomedical

Highly elastomeric poly(glycerol sebacate)-co-poly(ethylene glycol) amphiphilic block copolymers

Alpesh Patel et al.

BIOMATERIALS (2013)

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Article Chemistry, Multidisciplinary

A Versatile Synthetic Platform for a Wide Range of Functionalized Biomaterials

Zhengwei You et al.

ADVANCED FUNCTIONAL MATERIALS (2012)

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Review Chemistry, Multidisciplinary

Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications

Yulin Li et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Article Chemistry, Physical

On the origin of the steric effect

Balazs Pinter et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2012)

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Article Engineering, Biomedical

A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties

Zhengwei You et al.

BIOMATERIALS (2010)

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Injectable Double-Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment

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