4.8 Article

Tissue-Engineered Bone Functionalized with MoS2 Nanosheets for Enhanced Repair of Critical-Size Bone Defect in Rats

期刊

ADVANCED FUNCTIONAL MATERIALS
卷 32, 期 13, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202109882

关键词

bone regeneration; critical-size bone defects; extracellular matrix; NIR radiation; photothermal

资金

  1. Medical and Health Science and Technology Program of Zhejiang Province [2021RC085]
  2. Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents [2016-6]
  3. National Science Foundation of China [21874038]
  4. Shaanxi Normal University

向作者/读者索取更多资源

The study introduces a novel photothermal tissue-engineered bone (PTEB) by seeding mesenchymal stem cells and osteo-induction extracellular matrix in a specific scaffold, promoting bone regeneration under near-infrared radiation. Results demonstrate high biocompatibility and osteo-induction ability of PTEB both in vitro and in vivo.
Tissue-engineered bones have therapeutic potential for critical-size bone defects; however, the production of high quantities of the tissue-engineered bones with osteo-induction ability remains a huge challenge. Hyperthermia has been shown to up-regulate the expression of osteogenesis-related proteins to efficiently to promote bone regeneration. In this study, the authors develop a novel photothermal tissueengineered bone (PTEB) with osteo-induction ability and a biomimetic cellular environment. PTEB is generated by seeding rat bone mesenchymal stem cells (rBMMSCs) in the photothermal MoS2-biotin-garose-gelatin scaffold, and then overlaying the scaffold using osteo-induction extracellular matrix (OiECM). The rBMMSCs act as seeding cells, while OiECM provide a biomimetic microenvironment for repairing critical-sized cranial defects in rats. The results show that the PTEB exhibit high biocompatibility and osteo-induction ability under near-infrared (NIR) radiation. Results of in vitro experiments show that PTEB under NIR radiation promote proliferation and osteogenic differentiation of rBMMSCs. Furthermore, the PTEB implantation under NIR radiation significantly induces regeneration of bone in critical-size bone defects in rats 12 weeks after implantation. These findings indicate that PTEB has great potential in regenerative medicine and may represent an effective replacement for autografts used commonly in bone tissue engineering.

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