Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria-Killing

Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface plasmon resonance (LSPR) response in the near-infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal effects, resulting in dramatically increased peroxidase-like activity when exposed to 808 nm light. Both experimental results and theoretical calculations show that the remarkable catalytic performance of CuS@GDY is due to the unique hierarchical structure, narrow bandgap of GDY nanowalls, LSPR effect of CuS nanocages, fast interfacial electron transfer dynamics, and carbon vacancies on CuS@GDY. This plasmonic nanozyme exhibits rapid, efficient, broad-spectrum antibacterial activity (>99.999%) against diverse pathogens (methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, and Escherichia coli). This study not only sheds light on the mechanism of the nanozyme-/photocatalysis coupling process, but also opens up a new avenue for engineering plasmonic NIR light driven nanozymes for rapid synergistic photothermal and photo-enhanced nanozyme therapy.

Automated summary

This study develops a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes, which can enhance enzyme-like activity using localized surface plasmon resonance in the near-infrared region. The nanozyme exhibits rapid, efficient, and broad-spectrum antibacterial activity. This research not only reveals the mechanism of the nanozyme/photocatalysis coupling process, but also provides a new approach for engineering rapid synergistic photothermal and photo-enhanced nanozyme therapy.