期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 179, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.114020
关键词
cGAS-STING pathway; STING agonists; cGAMP; Adjuvant; Vaccine delivery; Nanoparticle; Cancer vaccines
资金
- Swiss National Science Foundation [315230_173243]
- ISREC Foundation
- Biltema Foundation
- Swiss Cancer Research foundation [KFS-4600-08-2018]
- European Research Council under the ERC [805337]
- Kristian Gerhard Jebsen Foundation
- Foundation Pierre Mercier pour la science, Anna Fuller Fund Grant
- EPFL
- Ghent University -Special Research Found [BOF PDO.2009.0006.01]
- FWO [V412920N]
- European Research Council (ERC) [805337] Funding Source: European Research Council (ERC)
This review discusses the mechanisms of STING agonists in vaccination, recent progress in novel STING agonist discovery and delivery strategies, as well as efforts in optimizing the efficacy and minimizing toxicity of STING agonist-assisted subunit vaccines. The future development of STING agonists for adjuvanting subunit vaccines is also discussed.
Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen recognition receptors have been developed as potent adjuvants to optimize the immunogenicity and efficacy of vaccines. Recently discovered cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has attracted much attention as it is a key mediator for modulating immune responses. Vaccines adju-vanted with STING agonists are found to mediate a robust immune defense against infections and cancer. In this review, we first discuss the mechanisms of STING agonists in the context of vaccination. Next, we present recent progress in novel STING agonist discovery and the delivery strategies. We next highlight recent work in optimizing the efficacy while minimizing toxicity of STING agonist-assisted subunit vac-cines for protection against infectious diseases or treatment of cancer. Finally, we share our perspectives of current issues and future directions in further developing STING agonists for adjuvanting subunit vaccines. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据