期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 178, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.113983
关键词
Patient-centric; Probiotics; Vaccines; Quality by design; ODF; QbD
资金
- Academy of Finland [336355]
Orodispersible films (ODFs) are a unique pharmaceutical dosage form that can improve patient compliance and convenience, particularly for pediatric and geriatric populations. They have the potential to serve as carriers for drugs, herbal extracts, probiotics, and vaccines, while also aiding in drug loading, taste masking, and stability enhancement.
Orodispersible films (ODFs) are ultra-thin, stamp-sized, elegant, portable and patient-centric pharmaceutical dosage forms that do not need water to be ingested. They are particularly useful for paediatric and geriatric patient populations with special needs such as dysphagia, Parkinson's disease, and oral cancer. Accordingly, they hold tremendous potential in gaining patient compliance, convenience and pharmacotherapy. In the present review, conception and evolution of ODFs as a product and its technology are discussed. The review continues by providing overview about the potential of ODFs as carriers for delivering drugs, herbal extracts, probiotics and vaccines. Besides, strategies employed in drug cargo loading, taste masking of bitter drugs and enhancing drug stability are discussed. Finally, the review concludes by providing a brief overview about quality by design (QbD) principles in development of ODFs. (c) 2021 Elsevier B.V. All rights reserved.
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