Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors

In recent years, personalized cancer vaccines have gained increasing attention as emerging immunother-apies with the capability to overcome interindividual differences and show great benefits for individual patients in the clinic due to the highly tailored vaccine formulations. A large number of materials have been studied as delivery vectors to enhance the therapeutic performance of personalized cancer vaccines, including artificial materials, engineered microorganisms, cells and cell derivatives. These delivery vec-tors with distinct features are employed to change antigen biodistributions and to facilitate antigen uptake, processing and presentation, improving the strength, velocity, and duration of the immune response when delivered by different strategies. Here, we provide an overview of personalized cancer vaccine delivery vectors, describing their materials, physicochemical properties, delivery strategies and challenges for clinical transformation. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

Personalized cancer vaccines have gained attention for their ability to overcome interindividual differences and show benefits for individual patients in the clinic. Various delivery vectors, including artificial materials, engineered microorganisms, cells and cell derivatives, have been studied to enhance the therapeutic performance of personalized cancer vaccines. These delivery vectors are utilized to improve antigen distribution and immune response strength, velocity, and duration through different delivery strategies.