4.7 Review

Advances in mRNA non-viral delivery approaches

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Summary: This commentary discusses the challenges surrounding the stability and formulation of mRNA vaccines, highlighting the need to optimize their formulation for enhanced stability during storage, transport, and administration. Additionally, the mRNA vaccine approach shows evidence of human immunogenicity against multiple viral pathogens and the ability to rapidly adapt to emerging infectious diseases.

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Lu Tan et al.

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Peptide-mediated delivery of therapeutic mRNA in ovarian cancer

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Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA

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The Development of Functional Non-Viral Vectors for Gene Delivery

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Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

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RNA Sensors of the Innate Immune System and Their Detection of Pathogens

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A Targeted and Stable Polymeric Nanoformulation Enhances Systemic Delivery of mRNA to Tumors

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Modified mRNA Vaccines Protect against Zika Virus Infection

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Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

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CPP-Assisted Intracellular Drug Delivery, What Is Next?

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Liposomal drug delivery systems: From concept to clinical applications

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Reprogramming human fibroblasts to pluripotency using modified mRNA

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Factors affecting the clearance and biodistribution of polymeric nanoparticles

Frank Alexis et al.

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The protamine family of sperm nuclear proteins

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GENOME BIOLOGY (2007)

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Toxicity of cationic lipids and cationic polymers in gene delivery

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Cationic lipids enhance siRNA-mediated interferon response in mice

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