4.7 Review

In vitro models to evaluate ingestible devices: Present status and current trends

期刊

ADVANCED DRUG DELIVERY REVIEWS
卷 178, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.addr.2021.113924

关键词

In vitro model; Stomach; Small intestine; Colon; Macroenvironment microenvironment; Organoid; Organ-on-a-chip

资金

  1. EPSRC Centre for Doctoral Train-ing in Formulation Engineering [EP/L015153/1]
  2. AstraZeneca AB RD, Gothenburg

向作者/读者索取更多资源

The development of orally ingestible medical devices requires the use of models that simulate the gastrointestinal environment on both a macro and micro scale. Various in vitro tools are available for characterizing these devices, each with its own benefits and limitations. The selection of models for evaluation should be based on the functionality and mechanism of the device.
Orally ingestible medical devices offer significant opportunity in the diagnosis and treatment of gastroin-testinal conditions. Their development necessitates the use of models that simulate the gastrointestinal environment on both a macro and micro scale. An evolution in scientific technology has enabled a wide range of in vitro, ex vivo and in vivo models to be developed that replicate the gastrointestinal tract. This review describes the landscape of the existing range of in vitro tools that are available to characterize ingestible devices. Models are presented with details on their benefits and limitations with regards to the evaluation of ingestible devices and examples of their use in the evaluation of such devices is pre-sented where available. The multitude of models available provides a suite of tools that can be used in the evaluation of ingestible devices that should be selected on the functionality of the device and the mechanism of its function. (c) 2021 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据