期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 181, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.114078
关键词
Antimicrobial resistance; B-lactamases; Carbapenem-resistant; Epidemiology; MDRO; Multiple resistance; Resistant organism
Antimicrobial resistance is a normal evolutionary process for microorganisms and has become a global crisis. Existing antimicrobials are no longer effective in treating infections caused by resistant pathogens. Novel drug delivery approaches offer new hopes in overcoming antimicrobial resistance and targeting hard-to-reach sites.
Antimicrobial resistance is a normal evolutionary process for microorganisms. Antibiotics exerted accelerated selective pressure that hasten bacterial resistance through mutation, and acquisition external genes. These genes often carry multiple antibiotic resistant determinants allowing the recipient microbe an instant super-bug status. The extent of Antimicrobial Resistance (AMR) has reached a level of global crisis, existing antimicrobials are no long effective in treating infections caused by AMR pathogens.The great majority of clinically available antimicrobial agents are administered through oral and intravenous routes. Overcoming antibacterial resistance by novel drug delivery approach offered new hopes, particularly in the treatment of AMR pathogens in sites less assessible through systemic circulation such as the lung and skin.In the current review, we will revisit the mechanism and incidence of important AMR pathogens. Finally, we will discuss novel drug delivery approaches including novel local antibiotic delivery systems, hybrid antibiotics, and nanoparticle-based antibiotic delivery systems.(c) 2021 Elsevier B.V. All rights reserved.
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