期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 177, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.113847
关键词
Sonopermeation; Perfusion; Extravasation; Extracellular matrix; Immune response; Nanomedicine
资金
- Central Norway Regional Health Authority [90270600]
- Norwegian Research Council [26228]
Nanomedicine has many advantages, but penetrating deep into the tumor stroma remains a challenge. Successful treatment requires overcoming delivery barriers such as crossing the capillary wall.
Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has many merits, but penetration deep into the tumor interstitium remains a challenge. Failure of cancer treatment can be caused by insufficient delivery of the therapeutic agents. After intravenous administration, nanomedicines are often found in off-target organs and the tumor extracellular matrix close to the capillary wall. With circulating microbubbles, ultrasound exposure focused toward the tumor shows great promise in improving the delivery of therapeutic agents. In this review, we address the impact of focused ultrasound and microbubbles to overcome barriers for drug delivery such as perfusion, extravasation, and transport through the extracellular matrix. Furthermore, we discuss the induction of an immune response with ultrasound and delivery of immunotherapeutics. The review discusses mainly preclinical results and ends with a summary of ongoing clinical trials. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
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