☆ 4.7 Review

Plant-derived nanotherapeutic systems to counter the overgrowing threat of resistant microbes and biofilms

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Computational refinement identifies functional destructive single nucleotide polymorphisms associated with human retinoid X receptor gene

Soumalya Sarkar et al.

Summary: Alterations in RXR signalling are associated with neurodegenerative disorders. This study identified deleterious SNPs that affect the structure and function of RXR isoforms. Seven missense mutations were found in RXR isoforms, including two novel mutations. In silico prediction tools were used to assess the pathogenicity and stability of RXR mutations. The analysis showed a mix of conclusive and inconclusive genotype-phenotype correlations.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

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Review Biochemistry & Molecular Biology

Green Synthesis of Metallic Nanoparticles and Their Prospective Biotechnological Applications: an Overview

Salem S. Salem et al.

Summary: Green synthesis of nanoparticles using biological methods offers advantages such as avoiding high pressure, temperature, toxic substances, and improving productivity and purity, making it environmentally friendly, clean, safe, cost-effective, and easy to use.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Bacterial biofilms in infective endocarditis: an in vitro model to investigate emerging technologies of antimicrobial cardiovascular device coatings

Alexander Lauten et al.

Summary: This study established a novel in vitro model for bacterial biofilm growth on porcine aortic roots mimicking IE, which may serve as a baseline for further research on IE therapy and prevention.

CLINICAL RESEARCH IN CARDIOLOGY (2021)

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Article Instruments & Instrumentation

Anacardic acid encapsulated solid lipid nanoparticles forStaphylococcus aureusbiofilm therapy: chitosan and DNase coating improves antimicrobial activity

Md Meraj Anjum et al.

Summary: Biofilm mediated bacterial infections are key in infectious disease progression due to antimicrobial resistance evolution. Traditional antibiotics are inadequate due to increased resistance. Anacardic acid loaded solid lipid nanoparticles offer a promising alternative with enhanced efficacy against biofilm-mediated antimicrobial resistance.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Infectious Diseases

Oxidative stress induced by piperine leads to apoptosis in Candida albicans

Archana Thakre et al.

Summary: The study showed that piperine significantly inhibits the growth of Candida albicans, especially when used in combination with fluconazole, demonstrating a synergistic effect. Proteome analysis indicates that piperine-induced membrane damage leads to oxidative stress, cell cycle arrest, and apoptosis.

MEDICAL MYCOLOGY (2021)

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Article Chemistry, Applied

Biomimetic amphiphilic chitosan nanoparticles: Synthesis, characterization and antimicrobial activity

Nuraziemah Ahmad et al.

Summary: Natural antimicrobial peptides (AMPs) are a promising source for new antimicrobial agents, but their clinical application is limited by poor bioavailability and toxicity. This study addresses these limitations by designing a new series of chitosan derivatives that mimic the structure of AMPs, with one derivative showing the most potent antimicrobial activity against Gram-negative bacteria while causing minimal cell death in tested cell lines. The results confirm the importance of cationicity and lipophilicity for selective bacteria targeting with the potential for chitosan nanoparticles as a new class of AMPs mimics effective against Gram-negative bacteria.

CARBOHYDRATE POLYMERS (2021)

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Review Biotechnology & Applied Microbiology

Strategies for antimicrobial peptide coatings on medical devices: a review and regulatory science perspective

Mehdi Kazemzadeh-Narbat et al.

Summary: This review discusses the use of antimicrobial peptides (AMPs) as an alternative to conventional antibiotics to reduce infections in medical devices, focusing on their broad-spectrum antimicrobial activity and strategies for incorporating them into medical devices materials. The regulatory perspective on AMP coatings, specifically in the US market, aims to bridge the gap between academic studies and preclinical testing to advance the regulatory science of antimicrobial coatings.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Antifungal activity and potential mechanism of magnoflorine againstTrichophyton rubrum

Nanxuan Luo et al.

Summary: Coptis alkaloids, especially magnoflorine, exhibit significant antifungal activities against T. rubrum and T. mentagrophyte. Magnoflorine inhibits conidia germination and hyphal growth, causing deformation growth, surface peeling, and cytoplasmic contraction in T. rubrum. It also destroys the fungal cell membrane through various mechanisms, making it a potential antifungal agent for clinical applications against T. rubrum.

JOURNAL OF ANTIBIOTICS (2021)

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Article Biotechnology & Applied Microbiology

Dual antifungal activity against Candida albicans of copper metallic nanostructures and hierarchical copper oxide marigold-like nanostructures grown in situ in the culture medium

A. Martinez et al.

Summary: The study aimed to determine the in vitro activity of copper nanoparticles and copper nanowires against Candida albicans strains, as well as assess their effects on morphology and submicron structure. Results showed that both copper nanoparticles and nanowires inhibited the growth of the tested C. albicans strains, with nanoparticles disrupting the cell wall and causing leakage of cytoplasm, and nanowires decreasing the number and size of fimbriae in the yeast cells. Furthermore, both types of copper materials formed hierarchical copper oxide nanostructures during the experiment, indicating potential as new therapeutic agents for candidiasis.

JOURNAL OF APPLIED MICROBIOLOGY (2021)

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Article Pharmacology & Pharmacy

Surface modification of PLGA nanoparticles with chitosan or Eudragit® RS 100: Characterization, prolonged release, cytotoxicity, and enhanced antimicrobial activity

Gulsel Yurtdas-Kirimlioglu et al.

Summary: In this study, Cefpodoxime proxetil (CEF) was modified using nanoparticles technology to create PLGA nanoparticles with extended release and enhanced antimicrobial activity, showing characteristics such as smaller particle size, cationic surface, biocompatibility, and a favorable in vitro release pattern. The modification with chitosan and Eudragit RS 100 significantly improved the antimicrobial efficacy of the nanoparticles against bacterial cells.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Dentistry, Oral Surgery & Medicine

The in vivo anti-Candida albicans activity of flavonoids

William Nguyen et al.

Summary: Flavonoids, particularly flavonols and chalcones, show significant in vivo antifungal activity against Candida albicans infections in mouse models. Structural similarities in hydroxyl residues among compounds within the same subclass of flavonoids may contribute to their antibiofilm activity. Further research is needed to elucidate the specific mechanisms of flavonoids as antifungal agents and to examine the translational significance of these in vivo studies in clinical trials for the treatment of oral candidiasis.

JOURNAL OF ORAL BIOSCIENCES (2021)

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Review Oncology

The Impact of Photosensitizer Selection on Bactericidal Efficacy Of PDT against Cariogenic Biofilms: A Systematic Review and Meta-Analysis

Mauricio Italo Silva Teofilo et al.

Summary: This study systematically reviewed the bactericidal efficacy of different photosensitizers against caries-related biofilms, finding that TBO, MBO, curcumin, and Photogem showed significant bacterial reduction effects. Methodological standardization remains a challenge in determining the most effective photosensitizer for PDT in caries treatment. Further clinical studies are needed for conclusive results.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Review Chemistry, Medicinal

Potential roles of medicinal plants for the treatment of viral diseases focusing onCOVID-19: A review

Bikash Adhikari et al.

Summary: The article discusses the potential inhibitory effects of various plant extracts on coronavirus and their potential as drug candidates for COVID-19. These plant compounds may also have inhibitory effects on other viruses, making it a promising area for research in drug discovery.

PHYTOTHERAPY RESEARCH (2021)

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Article Biology

Antifungal activity of nanoemulsion from Cleome viscosa essential oil against food-borne pathogenic Candida albicans

Rajapandiyan Krishnamoorthy et al.

Summary: The study investigated the antifungal properties of a nanoemulsion composed of Cleome viscosa essential oil and Triton-x-100 against food borne pathogenic C. albicans. The results showed significant reduction in biofilm of C. albicans isolates, alteration of molecular fingerprints, and reduction of chitin levels in cell walls, indicating collateral damage on C. albicans cells by the nanoemulsion and its bioactive compounds.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Voluntary-Opsonization-Enabled Precision Nanomedicines for Inflammation Treatment

Shuya Li et al.

Summary: This study leverages natural interactions with blood cells to turn the protein corona into an active ingredient for treating lung inflammation, achieving targeted neutrophil delivery. Molecularly engineered liposomes enhance complement fragment iC3b, triggering neutrophil phagocytosis, demonstrating effective neutrophil reconstruction in activated cells. Liposome-loaded neutrophils migrate and accumulate in inflamed lung parenchyma, releasing payloads to kill bacteria.

ADVANCED MATERIALS (2021)

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Review Medicine, Research & Experimental

Exploring the multifocal role of phytochemicals as immunomodulators

Tapan Behl et al.

Summary: The well-functioning immune system of the host body is crucial for maintaining normal physiological and immunological functions, as well as the internal environment. Balancing immunity enhances defense mechanisms against infections, diseases, and unwanted pathogens to prevent hypersensitivity reactions and immune-related diseases. Recent interest in the immune system as a significant target for toxicity has increased due to exposure to chemicals, drugs, and environmental pollutants. Various factors such as sex, age, stress, malnutrition, alcohol, genetic variability, lifestyles, environmental pollutants, and chemotherapy exposure can alter immune responses. Immunomodulation involves modifying immune responses through induction, amplification, attenuation, or inhibition. Phytochemicals, including glycosides, alkaloids, phenolic acids, flavonoids, saponins, tannins, sterols, and sterolins, play a key role in modulating favorable immune responses.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Chemistry, Applied

Chitosan-based nanoparticles against bacterial infections

Somaye Rashki et al.

Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.

CARBOHYDRATE POLYMERS (2021)

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Article Biophysics

Antibacterial and antibiofilm properties of graphene and its derivatives

Guihua Cao et al.

Summary: The review discusses the antibacterial and antibiofilm effects of graphene and its derivatives, including a review of their abilities in solution and on surfaces, as well as exploration of their toxicity and possible mechanisms. Possible future research directions are also proposed.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Microbiology

Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)

Bryn Short et al.

Summary: Haemophilus influenzae is a common cause of bacterial infection in the lungs of COPD patients, leading to acute exacerbations. Its ability to adhere to host epithelial cells, form biofilms, and persist through immune evasion and antibiotic tolerance plays a crucial role in the pathogenesis of COPD.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

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Review Pharmacology & Pharmacy

Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications

Yan Shan Loo et al.

Summary: Smart nanocarriers derived from bacteria and viruses exhibit versatile biomimetic properties, making them suitable for use in biosensors, biomedical scaffolds, immobilization, diagnostics, and targeted or personalized treatments. Biomimetic technology plays a crucial role in pharmaceuticals, allowing for the safe integration of naturally occurring bacteria and virus particles.

DRUG DISCOVERY TODAY (2021)

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Review Chemistry, Multidisciplinary

Nanoemulsions of essential oils to improve solubility, stability and permeability: a review

Thais Nogueira Barradas et al.

Summary: The increasing demand for healthier, safer, and environmentally-friendly products has brought essential oils to the forefront as a natural alternative to synthetic pharmaceuticals. Encapsulation of essential oils in nanoemulsions offers a solution to their limitations, improving the efficiency of pharmaceutical dosage.

ENVIRONMENTAL CHEMISTRY LETTERS (2021)

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Review Biochemistry & Molecular Biology

Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases

Pawel Sledzinski et al.

Summary: There is a growing interest in the medical applications of Cannabis plants, particularly in the unique properties of phytocannabinoids. Studies have shown that cannabinoids can interact with cannabinoid receptors in animals, and potentially have therapeutic effects in various diseases. More research is needed to fully understand the cellular and molecular response to cannabinoids, which will provide insight into their mechanism, potency, and safety profile for potential use as therapeutic agents.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Inorganic & Nuclear

Advances and perspectives in organic sonosensitizers for sonodynamic therapy

Xuejian Xing et al.

Summary: Sonodynamic therapy (SDT) is a promising minimally invasive approach for deep tumor treatment by combining low-intensity ultrasound (US) and a chemical sonosensitizer. Organic sonosensitizers have advantages like defined chemical structure and high ROS generation, but they often face challenges such as poor water solubility and low tumor targeting capacity. Strategies to improve these issues and combine SDT with other cancer treatments are discussed in this review.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Biotechnology & Applied Microbiology

Enhancing the fungicidal activity of amphotericin B via vacuole disruption by benzyl isothiocyanate, a cruciferous plant constituent

N. Yamada et al.

Summary: BITC enhances the fungicidal effects of AmB in yeast by amplifying vacuolar membrane disruption. This combinatorial antifungal effect may lead to dose reduction of AmB in clinical therapy and decrease side effects in patients, making it a potentially valuable strategy for combating fungal infections.

LETTERS IN APPLIED MICROBIOLOGY (2021)

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Article Materials Science, Biomaterials

One-spot fabrication and in-vivo toxicity evaluation of core-shell magnetic nanoparticles

Kamlesh V. Chandekar et al.

Summary: This research presents the synthesis of PAA-coated CF core-shell magnetic nanoparticles for biomedical applications. The NPs demonstrated good antimicrobial performance and biocompatibility with normal splenic cells. In vivo studies are needed to further explore biodistribution and chronic toxicity.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Materials Science, Multidisciplinary

How to design nanoporous silica nanoparticles in regulating drug delivery: Surface modification and porous control

Ruoshi Zhang et al.

Summary: NSNs have been considered as promising drug delivery agents due to their superior properties. By utilizing intelligent strategies such as molecular/supramolecular switches and lipid membrane wrapping, NSNs can greatly improve regulation of drug delivery, leading to better efficacy, especially in anticancer applications.

MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS (2021)

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Review Microbiology

Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

Jeronimo Rodriguez-Beltran et al.

Summary: Plasmids play a vital role in bacterial ecology and evolution by mobilizing accessory genes through horizontal gene transfer. Recent studies show that plasmids, kept at multiple copies per cell, create islands of polyploidy in bacterial genomes, leading to evolution governed by different rules than those affecting chromosomal genes. Plasmids may accelerate bacterial evolution by promoting the evolution of plasmid-encoded genes and enhancing the adaptation of their host chromosomes.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Agronomy

Antibacterial mechanism of Biochanin A and its efficacy for the control of Xanthomonas axonopodis pv. glycines in soybean

Kai-Xuan Hu et al.

Summary: Biochanin A exhibits higher antibacterial activity against Xanthomonas axonopodis pv. glycines (Xag) compared to genistein, inhibiting DNA synthesis and flagella formation. It also reduces swimming motility, extracellular protease activity, and biofilm formation in Xag, suggesting potential applications for managing bacterial pustule disease.

PEST MANAGEMENT SCIENCE (2021)

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Article Veterinary Sciences

Antimicrobial use and practices by animal health professionals in 20 sub-Saharan African countries

Stanly Fon Tebug et al.

Summary: The study reveals that there are issues with antimicrobial use and prescription practices among veterinary doctors, mainly due to lack of accurate diagnosis and appropriate treatment. Lack of diagnostic facilities and susceptibility tests were identified as major barriers to adequate prescriptions and use of antimicrobial drugs.

PREVENTIVE VETERINARY MEDICINE (2021)

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Article Food Science & Technology

Antibacterial mechanisms and applications of metal-organic frameworks and their derived nanomaterials

Jianghua Liu et al.

Summary: Metal-organic frameworks (MOFs) have emerged as new tools to combat bacterial infection in biomedical and food packaging fields. Recent progress in this area has highlighted the potential of MOFs and their derived nanomaterials as effective antibacterial agents. Their high surface areas, tunable porosity, and flexible skeletons make them promising materials for further research and development in antibacterial applications.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Article Plant Sciences

A brief history of plants in north-eastern France: 6,000 years of crop introduction in the Plain of Troyes, Champagne

Francoise Toulemonde et al.

Summary: The history of the Plain of Troyes began with the early Neolithic farmers introducing staple crops, and continued through various agricultural changes until the Roman era, which saw significant agricultural innovations. The true development of viticulture occurred during the Early Middle Ages. Despite gaps in historical records, some legacies of the past are still visible in contemporary agricultural practices.

VEGETATION HISTORY AND ARCHAEOBOTANY (2021)

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Article Biotechnology & Applied Microbiology

Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential

Maud Weiss et al.

Summary: This study clearly demonstrates that the surface charge density of a cationic carbon NP rather than the absolute value of its zeta-potential is a relevant descriptor of its in vitro and in vivo toxicity. The study found that among the cationic carbon NPs examined, only NP5 and NP6 with the highest surface charge density induced significant oxidative stress, IL-8 release, mitochondrial dysfunction, and loss in lysosomal integrity in cells. Additionally, NP5 and NP6 were the only NPs to induce airway inflammation in mice, with NP5 also increasing allergen-induced immune response, airway inflammation, and mucus production.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biology

Identification of carbapenems resistant genes on biofilm forming K. pneumoniae from urinary tract infection

Govindan Nadar Rajivgandhi et al.

Summary: The study identified the multi-drug resistance and carbapenem resistance of K. pneumoniae using specific antibiotics and detection methods, confirming its carbapenemase-producing and highly virulent nature through strong biofilm formation.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Chemistry, Multidisciplinary

In Vivo Toxicity Assessment of Chitosan-Coated Lignin Nanoparticles in Embryonic Zebrafish (Danio rerio)

Jared S. Stine et al.

Summary: The study found that chitosan-coated lignin nanoparticles were more toxic at high concentrations compared to plain nanoparticles, resulting in higher mortality rates and significant sublethal endpoints. Further research is needed to fully understand the mechanisms of toxicity of chitosan-coated lignin nanoparticles.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment

John Jairo Aguilera-Correa et al.

Summary: Infectious diseases rank third in the top 10 causes of death worldwide, accounting for over 6.7 million deaths in 2016. Nanomedicine, which uses nanotechnology for medical purposes, involves the use of nanoparticles for diagnosing, monitoring, controlling, preventing, and treating diseases, including infectious ones. Nanoparticles, with their highly tunable physical and optical properties, are widely used in nanomedicine for preventing and treating human infectious diseases caused by various viruses and bacteria.

NANOMATERIALS (2021)

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Article Public, Environmental & Occupational Health

The interrelationships between antimicrobial resistance, COVID-19, past, and future pandemics

Hyacinth O. Ukuhor

Summary: The COVID-19 pandemic has resulted in high morbidity and mortality rates, with some cases showing resistance to antimicrobials leading to worse outcomes. Antimicrobial-resistant co-infections have been a significant factor in clinically significant mortality. Various factors such as misuse of antimicrobials, international travel, healthcare financing issues, human use/misuse, agricultural production, and climate change are determinants of antimicrobial resistance.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2021)

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Article Pharmacology & Pharmacy

Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains

Federica Rinaldi et al.

Summary: The essential oil of Satureja montana was formulated into oil in water nanoemulsions to enhance its antimicrobial and antibiofilm properties against Escherichia coli strains. Through the construction of a ternary phase diagram and optimization, the nanoemulsion formulation showed effective reduction of bacterial colonization and biofilm production. This optimized formulation holds significant implications for poultry food safety and combating antibiotic resistance in E. coli strains.

PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Antibody-Conjugated Nanocarriers for Targeted Antibiotic Delivery: Application in the Treatment of Bacterial Biofilms

Hung Le et al.

Summary: Conventional antibiotic treatments often fail to eradicate biofilm-related infections, but novel methods of antibiotic delivery such as targeting nanoparticulate systems show promise in enhancing bactericidal activity against commonly virulent pathogens like Staphylococcus aureus. Studies have demonstrated improved therapeutic efficacy and elevated accumulation of antibiotics in biofilms using targeting nanoparticle systems, suggesting a potential strategy to enhance antibiotic biodistribution and efficacy.

BIOMACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Triphenyl-sesquineolignan analogues derived from Illicium simonsii Maxim exhibit potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) by disrupting bacterial membranes

Yong Guo et al.

Summary: In this study, three triphenyl-sesquineolignans were isolated and seven derivatives were prepared. Compound 6 showed the best antibacterial activity against Gram-positive bacteria and clinical MRSA strains, with low drug resistance development probability and hemolysis. Mechanism studies revealed that compound 6 kills bacterial strains by disrupting membranes, indicating its potential as a new antibacterial candidate for combating MRSA infections.

BIOORGANIC CHEMISTRY (2021)

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Article Chemistry, Applied

Boosting the antibacterial activity of chitosan-gold nanoparticles against antibiotic-resistant bacteria by Punicagranatum L. extract

Mohamed A. Mohamady Hussein et al.

Summary: A new series of chitosan-gold hybrid nanoparticles were synthesized for delivering pomegranate peel extract, with pomegranate peel acting as a reducing agent leading to a significant reduction in particle size. The developed nanoparticles exhibited higher stability at different pH values and released most of the loaded extract over a 24-hour period. The antibacterial activity of the nanoparticles showed a synergistic effect against methicillin-resistant S. aureus.

CARBOHYDRATE POLYMERS (2021)

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Article Engineering, Environmental

Highly efficient near-infrared photothermal antibacterial membrane with incorporated biogenic CuSe nanoparticles

Xue-Meng Wang et al.

Summary: Low-cost photothermal antibacterial membranes were fabricated using biogenic copper selenide nanoparticles, improving membrane antibacterial properties and water flux.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Immunology

National Estimates of Healthcare Costs Associated With Multidrug-Resistant Bacterial Infections Among Hospitalized Patients in the United States

Richard E. Nelson et al.

Summary: This study estimated the healthcare costs associated with infections due to multidrug-resistant bacteria in the United States, revealing that these infections resulted in substantial healthcare costs.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Environmental Sciences

Prevalence of multi-resistant plasmids in hospital inhalable particulate matter (PM) and its impact on horizontal gene transfer

Zhen-Chao Zhou et al.

Summary: This study demonstrated the presence of multi-resistant plasmids in inhalable particulate matter and their significant impact on gene horizontal transfer. PM2.5 and PM10 were shown to increase conjugative transfer rates and reactive oxygen species levels. The study highlights the airborne spread of multi-resistant plasmids and the influence of inhalable PM on antibiotic resistance gene transfer.

ENVIRONMENTAL POLLUTION (2021)

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Article Biochemistry & Molecular Biology

Green synthesis, antimicrobial, antibiofilm and antitumor activities of superparamagnetic γ-Fe2O3 NPs and their molecular docking study with cell wall mannoproteins and peptidoglycan

Mohammad Azam Ansari et al.

Summary: In this study, fatty acids-assisted superparamagnetic maghemite nanoparticles were biologically synthesized using extract of polyherbal drug Liv52. The nanoparticles were characterized by various techniques and were found to contain saturated and unsaturated fatty acids as well as aromatic phenol compounds. The nanoparticles exhibited antimicrobial, antibiofilm, and anticancer activities, and molecular docking studies suggested efficient interaction with cell wall components. The magnetic properties of the nanoparticles could potentially enhance their biological activity when combined with external magnetic fields or other therapeutic drugs.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Pharmacology & Pharmacy

Quantum dots: Prospectives, toxicity, advances and applications

Bina Gidwani et al.

Summary: Quantum dots are fluorescence semiconductor nano particles made of heavy metal or inorganic material, with unique properties for drug molecule binding and cellular delivery. Their surface modification enhances aqueous solubility and provides effective surface area for drug targeting. With various functionalization, quantum dots find applications in biomedical imaging, drug delivery, and diagnosis, showing potential for improving pharmacological action.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

An overview on nanoparticles used in biomedicine and their cytotoxicity

Mohammad Nikzamir et al.

Summary: Nanotechnology involves developing engineered nanoparticles for biomedical applications, which have unique physicochemical properties but can exhibit cytotoxicity causing concerns for clinical applications. To be successful in biomedical applications, nanoparticles must be non-toxic and biocompatible, as their small size allows them to easily enter the body and potentially reach sensitive organs. The cytotoxicity of nanoparticles depends on various factors such as size, shape, charge, chemistry, and modifications, with the main mechanism being the generation of reactive oxygen species leading to oxidative stress and cell damage. Various commonly used nanoparticles in biomedicine, including carbon-based nanoparticles, metallic nanoparticles, and quantum dots, are discussed along with their possible cytotoxicity mechanisms.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Undecanoic Acid, Lauric Acid, and N-Tridecanoic Acid Inhibit Escherichia coli Persistence and Biofilm Formation

Xing Jin et al.

Summary: Fatty acids show promise as antipersister and antibiofilm agents, with medium-chain saturated fatty acids such as undecanoic acid and lauric acid being particularly effective at inhibiting persister cell formation in E. coli and enterohemorrhagic E. coli. These fatty acids not only repress persister formation but also reduce biofilm formation, demonstrating their potential for treating bacterial infections.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Review Chemistry, Physical

Nanoparticle drug conjugates treating microbial and viral infections: A review

Srikanth Gatadi et al.

Summary: The rise in drug resistance to conventional antimicrobial agents has become a major healthcare threat globally, while the development of nanoparticle drug conjugates shows promising potential in overcoming challenges posed by traditional medications. Potential multi-functional nanoparticle drug conjugates could revolutionize clinical medicine and play a crucial role in reducing disease burden.

JOURNAL OF MOLECULAR STRUCTURE (2021)

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Article Materials Science, Biomaterials

Polymeric antibiofilm coating comprising synergistic combination of citral and thymol prevents methicillin-resistant Staphylococcus aureus biofilm formation on titanium

Alaguvel Valliammai et al.

Summary: Microbial infections associated with biomaterials are challenging and often require revision surgery. To address this issue, recent treatment strategies have focused on modifying implant surfaces to prevent bacterial adhesion, with antibiofilm coatings proving to be an effective approach. This study identified the synergistic antibiofilm activity of citral and thymol, leading to the development of a polymeric antibiofilm coating that effectively inhibited MRSA adherence in vitro. The coating showed sustained release of active ingredients and was non-toxic, demonstrating its potential for clinical applications in preventing biomaterial-associated infections.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Immunology

Antibiofilm agent pterostilbene is able to enhance antibiotics action against Staphylococcus epidermidis

P. Kasparova et al.

Summary: Pterostilbene (PTE) is a natural compound with antioxidant and antimicrobial properties, which can enhance the effectiveness of erythromycin and tetracycline in inhibiting the growth and biofilm formation of Staphylococcus epidermidis. PTE was found to effectively inhibit S. epidermidis, reduce metabolic activity of biofilm cells, and enhance the action of antibiotics in overcoming biofilm cell tolerance.

MICROBIAL PATHOGENESIS (2021)

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Article Microbiology

A mutagenic screen reveals NspS residues important for regulation of Vibrio cholerae biofilm formation

Erin C. Young et al.

Summary: Biofilm formation in Vibrio cholerae is partly regulated by norspermidine, spermidine, and spermine through a signaling pathway involving the periplasmic protein NspS and the integral membrane c-di-GMP phosphodiesterase MbaA. In this pathway, polyamine binding to NspS likely affects its interaction with MbaA, leading to either activation or inhibition of biofilm formation. Mutagenesis studies identified important amino acids in NspS for its function, shedding light on the novel signaling pathway and the role of periplasmic binding proteins in V. cholerae.

MICROBIOLOGY-SGM (2021)

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Review Oncology

Photodynamic therapy to control microbial biofilms

Anjali Warrier et al.

Summary: Microorganisms in biofilms show increased resistance to antibiotics, prompting the need for advanced antimicrobial approaches. Photodynamic therapy, as a safe and non-toxic treatment strategy, is increasingly used for chronic infections, extending its potential applications in various medical conditions.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Article Chemistry, Applied

Enhanced antimicrobial, antibiofilm and anticancer activities of biocompatible neem gum coated palladium nanoparticles

N. Prakashkumar et al.

Summary: This study fabricated biocompatible neem gum coated palladium nanoparticles and evaluated their pharmacological applications, demonstrating enhanced antimicrobial and anticancer properties of NG@Pd NPs compared to Pd NPs alone, making them promising candidates for antimicrobial and lung cancer therapy.

PROGRESS IN ORGANIC COATINGS (2021)

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Article Environmental Sciences

Effects on photosynthetic and antioxidant systems of harmful cyanobacteria by nanocrystalline Zn-MOF-FA

Xiaoxiong Wang et al.

Summary: Metal-organic frameworks (MOFs) have been recently used by researchers for controlling cyanobacteria, and combining MOFs with allelochemicals for cyanobacteria inhibition has shown to be more effective, mainly due to hindering electron transfer and energy capture in the photosynthetic system, and oxidative damage caused by reactive oxygen species (ROS).

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Immunology

Speciality Grand Challenge for Biofilms

Christophe Beloin et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Biology

Inhibition of biofilm formation by alpha-mangostin loaded nanoparticles against Staphylococcus aureus

Phuong T. M. Nguyen et al.

Summary: This study demonstrated that alpha-mangostin (AMG) loaded nanoparticles (nanoAMG) had superior antibiofilm activity compared to free AMG, effectively inhibiting biofilm formation and killing biofilm cells of Staphylococcus aureus strains, including the methicillin-resistant MRSA252. The expression of biofilm-related genes also showed noticeable differences between strains when treated with AMG or nanoAMG.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Materials Science, Multidisciplinary

Influence of clove essential oil immobilized in mesoporous silica nanoparticles on the functional properties of poly(lactic acid) biocomposite food packaging film

Wangwei Lu et al.

Summary: Clove essential oil was immobilized in mesoporous silica nanoparticles and incorporated into poly(lactic acid) matrix to form nanocomposite films with improved mechanical properties, sustained release profile of CEO, and efficient antimicrobial activity, showing promising features for active food packaging materials.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2021)

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Review Pharmacology & Pharmacy

Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles

Anan Yaghmur et al.

Summary: The article focuses on the recent advances and advantages of ISAsomes (including cubosomes and hexosomes) and SLNs as nanocarriers for drug delivery, with a discussion on their applications in oral and pulmonary drug delivery. It highlights the need for further research on the interactions of these nanoparticles with biological fluids and tissues for efficient designing of drug nanocarriers and exploring potential clinical applications.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Pharmacology & Pharmacy

The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin

Baode Shen et al.

Summary: The study revealed that the size of the nanoparticles affects the absorption and biodistribution of the drug, with smaller particles being more easily absorbed but dissolving faster in vivo, leading to higher drug distribution but lower accumulation of integral nanocrystals in the liver. Larger particles, on the other hand, show slower dissolution and higher liver distribution due to enhanced recognition by RES. The absolute exposure of integral nanocrystals to oral bioavailability enhancement was unexpectedly high, indicating a significant difference in absorption and biodistribution between integral nanocrystals and overall drugs following oral and intravenous administration.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Microbiology

Metallic Nanoparticles-Friends or Foes in the Battle against Antibiotic-Resistant Bacteria?

Francisco Amaro et al.

Summary: Metallic nanoparticles are promising tools for infection control due to their unique properties, but bacteria can still develop stable resistance mechanisms against them. Careful management is necessary to preserve the efficacy of these antimicrobials.

MICROORGANISMS (2021)

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Article Microbiology

Anti-Biofilm Activity of Cannabidiol against Candida albicans

Mark Feldman et al.

Summary: CBD exerts pronounced inhibitory effects on Candida albicans biofilm formation and disruption, acting through multiple pathways to alter biofilm structure, fungal morphology, and repress virulence-associated genes.

MICROORGANISMS (2021)

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Article Dentistry, Oral Surgery & Medicine

Antimicrobial effects of silver nanoparticles and extracts of Syzygium cumini flowers and seeds: Periodontal, cariogenic and opportunistic pathogens

Wagner Luis de Carvalho Bernardo et al.

Summary: This study investigated the antimicrobial effects of lyophilized hydroalcoholic extract and silver nanoparticles of S. cumini seed and flower, finding that they exhibited varying degrees of antimicrobial activity against different pathogens. The AgNPs had stronger bacteriostatic and fungistatic effects than the plant extracts but required significantly lower concentrations.

ARCHIVES OF ORAL BIOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Ursolic acid inhibits multi-species biofilms developed by Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii

Xiaoying Lyu et al.

Summary: The study found that UA exhibited significant antimicrobial activity against common oral streptococci, reduced EPS synthesis of oral streptococci, and suppressed gtf genes' expression. Furthermore, UA decreased the proportion of S. mutans in multi-species biofilms and showed low cytotoxicity against HOKs and HGEs.

ARCHIVES OF ORAL BIOLOGY (2021)

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Review Engineering, Environmental

Shape matters: Morphologically biomimetic particles for improved drug delivery

Jie Wang et al.

Summary: The morphology of organisms has inspired biomimetic engineering to create novel nanostructures for drug delivery and diagnostic purposes. Shaping particles by mimicking natural biological entities offers great potential for benefiting human health.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Food Science & Technology

Enhancing effect of nanoemulsion on antimicrobial activity of cinnamon essential oil against foodborne pathogens in refrigerated Asian seabass (Lutes calcarifer) fillets

Piyanan Chuesiang et al.

Summary: The study showed that nanoemulsion formulation of cinnamon essential oil demonstrated improved antimicrobial activity against pathogenic bacteria in refrigerated Asian seabass fillets. The nanoemulsion was more effective in inhibiting the growth of bacteria, especially Vibrio parahaemolyticus, compared to bulk cinnamon oil and sodium hypochlorite.

FOOD CONTROL (2021)

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Review Biochemistry & Molecular Biology

Biological effects of formation of protein corona onto nanoparticles

Rakesh Kumar Mishra et al.

Summary: The formation of protein corona has significant implications on various attributes of nanomaterials based medicinal and drug carrier systems, influencing their fate in vivo and in vitro. This interaction significantly impacts the pharmacological, toxicological, and carrier characteristics of nanoparticles, with effects on biocompatibility traits.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression

Bonglee Kim et al.

Summary: Biocompatible nanoparticles have advanced imaging diagnosis and targeted cancer therapy, with some drugs already on the market. However, phytochemical nanoparticles face challenges such as poor bioavailability, resistance, and toxicity that need to be overcome for clinical translation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Medicinal

Biochemical Properties and Anti-Biofilm Activity of Chitosan-Immobilized Papain

Diana R. Baidamshina et al.

Summary: Chitosan, a product of chitin deacetylation, is a beneficial carrier for enzyme immobilization, enhancing the anti-biofilm activity and antimicrobial efficacy of papain against biofilm-embedded bacteria. Immobilized papain on medium molecular weight chitosan shows potential for wound treatment by destroying biofilms and increasing antimicrobial effectiveness.

MARINE DRUGS (2021)

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Article Engineering, Biomedical

Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity

Yin Shi et al.

Summary: This study presents a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance antimicrobial efficacy while avoiding side effects. The developed surface-nanoengineered antimicrobial liposome (SNAL) possesses virus-like infection to bacterial cells, mediating high-efficiency bacteria binding, rapid attack, and irreversible damage of cell membrane. The viral mimics show promising effectiveness against multiple pathogens and low toxicity, suggesting potential for next-generation antimicrobial design.

BIOACTIVE MATERIALS (2021)

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Article Immunology

Expression of RND efflux pumps mediated antibiotic resistance in Pseudomonas aeruginosa clinical strains

Abed Zahedi Bialvaei et al.

Summary: The study identified that clinical isolates of Pseudomonas aeruginosa commonly express RND efflux pumps, leading to antibiotic resistance. Overexpression of mexB and mexY in ICU wards was significantly prevalent in the studied strains, correlating with resistance to most anti-pseudomonal antibiotics.

MICROBIAL PATHOGENESIS (2021)

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Review Biochemistry & Molecular Biology

Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2

Arumugam Vijaya Anand et al.

Summary: This article summarizes the potential antiviral activities of certain phytochemical agents against important viral pathogens, with a special focus on herbs and medicinal plants that have shown promising results in combating SARS-CoV-2 infection.

MOLECULES (2021)

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Article Nanoscience & Nanotechnology

Rosin modified aminated mesoporous silica adsorbed tea tree oil sustained-release system for improve synergistic antibacterial and long-term antibacterial effects

Songfa Qiu et al.

Summary: In this study, a biocompatible carrier loaded with tea tree essential oil was prepared to address the issue of volatile nature inhibiting the effective use of tea tree oil. Through chemical and electrostatic interactions, a low volatilization rate of tea tree essential oil was achieved, leading to a synergistic antibacterial effect between sodium rosin and tea tree essential oil. The chemically modified system exhibited a longer sustained release and better antibacterial properties compared to the electrostatic effect, with the samples demonstrating long-term antibacterial performance as well.

NANOTECHNOLOGY (2021)

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Article Veterinary Sciences

Antimicrobial use in household, semi-industrialized, and industrialized pig and poultry farms in Viet Nam

Luu Quynh Huong et al.

Summary: The main reasons for antimicrobial use on farms in Vietnam include treatment of sick animals, disease prevention, and weight gain. Industrial pig farms are more likely to conduct diagnostic tests before using antimicrobials compared to household farms.

PREVENTIVE VETERINARY MEDICINE (2021)

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Article Multidisciplinary Sciences

Antibacterial and antibiofilm activities of cinnamon essential oil nanoemulsion against multi-species oral biofilms

Yeo-Jin Jeong et al.

Summary: The study demonstrated that nanoemulsified cinnamon essential oil effectively inhibited the maturation of multi-species oral biofilms and the growth of oral microorganisms, including aciduric bacteria that cause dental caries.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

Caio H. N. Barros et al.

Summary: Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with intrinsic antibacterial activity, showing enhanced penetration into biofilms and improved antibacterial activity compared to free curcumin. These nanoparticles are also efficient at disrupting mature biofilms and inhibiting bacterial growth within biofilms, suggesting their potential for drug delivery applications.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Engineering, Chemical

Contribution of Essential Oils to the Fight against Microbial Biofilms-A Review

Diana Camelia Nuta et al.

Summary: Essential oils (EOs) show great potential as a new modality for eradicating microbial biofilms, with promising mechanisms of microbicidal and antibiofilm activity, including synergistic effects with other antimicrobials. Although testing their antimicrobial activity is challenging due to the lipophilicity and volatility of EOs, recent methods have been developed to facilitate these tests.

PROCESSES (2021)

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Review Immunology

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Thai Thanh Hoang Thi et al.

Summary: This review highlights the importance of lipid-based nanoparticles in the development of COVID-19 vaccines and other nanomedicines, focusing on innovations that have obtained regulatory approval or are in clinical trials. It also discusses the physicochemical properties required for specific applications, emphasizes the differences in requirements for delivering different cargos, and introduces current challenges that need further development.

VACCINES (2021)

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Article Engineering, Environmental

Needleless electrospun phytochemicals encapsulated nanofibre based 3-ply biodegradable mask for combating COVID-19 pandemic

Nikhil Avinash Patil et al.

Summary: The emergence of COVID-19 pandemic has highlighted the importance of face masks for personal protection, and this multi-layer face mask containing phytochemicals has demonstrated superior air permeability and bacterial filtration efficiency, making it suitable for everyday use and medical practices.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Injectable biomimetic hydrogels encapsulating Gold/metal-organic frameworks nanocomposites for enhanced antibacterial and wound healing activity under visible light actuation

Zhiwen Deng et al.

Summary: This study introduced a biomimetic injectable double-network hydrogel using semiconductor nanomaterials to enhance ROS generation for antibacterial properties and wound healing acceleration.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biophysics

Use of 18β-glycyrrhetinic acid nanocrystals to enhance anti-inflammatory activity by improving topical delivery

Weiyan Quan et al.

Summary: Beta-Glycyrrhetinic acid (GA) is commonly used for treating inflammatory skin diseases topically, but its poor solubility in water limits its effectiveness. Nanocrystallization of GA can enhance its dermal permeability and anti-inflammatory activity. Nano GA showed improved dermal permeability and stronger anti-inflammatory effects compared to Coarse GA, suggesting its potential as a topical therapeutic agent for skin inflammation.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Food Science & Technology

Resveratrol influences the pathogenesis of Aeromonas hydrophila by inhibiting production of aerolysin and biofilm

Jing Dong et al.

Summary: Aeromonas hydrophila is a widely distributed pathogen that has developed antibiotic resistance, necessitating the exploration of novel treatment strategies. The bacterium's pathogenicity is primarily attributed to virulence factors such as aerolysin and biofilm.

FOOD CONTROL (2021)

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Article Biotechnology & Applied Microbiology

Pore-forming treatments induce aggregation of Salmonella Senftenberg through protein leakage

Amit Hollander et al.

Summary: The study revealed that the major constituent of basil oil, linalool, can increase the permeability of Salmonella cells and induce bacterial aggregation, promoting bacterial aggregation. The membrane perforation effect triggers bacterial aggregation by leaking intracellular substances, and non-specific proteins further contribute to bacterial aggregation.

FOOD MICROBIOLOGY (2021)

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Article Pharmacology & Pharmacy

Ceftriaxone sodium loaded onto polymer-lipid hybrid nanoparticles enhances antibacterial effect on gram-negative and gram-positive bacteria: Effects of lipid- polymer ratio on particles size, characteristics, in vitro drug release and antibacterial drug efficacy

Arash Rigi Hossein Abadi et al.

Summary: This study demonstrated the enhanced antibacterial effect of hybrid polymer-lipid nanoparticles containing ceftriaxone sodium on Escherichia coli and Enterococcus faecium, with sustained drug release properties. The nanoparticles showed promising potential in reducing bacterial resistance.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Formulation of pH-responsive lipid-polymer hybrid nanoparticles for co-delivery and enhancement of the antibacterial activity of vancomycin and 18β-glycyrrhetinic acid

Yajna Jaglal et al.

Summary: This study developed novel lipid-polymer hybrid nanoparticles for co-delivery of vancomycin and beta-glycyrrhetinic acid, demonstrating enhanced antibacterial potential against methicillin-resistant Staphylococcus aureus and efficient drug release in acidic conditions. These nanoparticles have the potential to serve as promising nanocarriers for improving antibiotic drug delivery and antibacterial activity.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Medicine, Research & Experimental

An innovative role for luteolin as a natural quorum sensing inhibitor in Pseudomonas aeruginosa

Ya Fei Geng et al.

Summary: This study investigated the potential of luteolin as a quorum sensing inhibitor against Pseudomonas aeruginosa, demonstrating its effectiveness in inhibiting biofilm formation, virulence factor production, and bacterial motility. Luteolin was also found to reduce the accumulation of QS signaling molecules and downregulate the transcription of QS genes, suggesting its promising role in combating drug-resistant infections caused by P. aeruginosa.

LIFE SCIENCES (2021)

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Article Oncology

The anti-biofilm capability of nano-emodin-mediated sonodynamic therapy on multi-species biofilms produced by burn wound bacterial strains

Maryam Pourhajibagher et al.

Summary: The study confirmed the significant anti-biofilm efficacy of nano-emodin-mediated sonodynamic therapy against multi-species bacterial biofilms, showing reduction in biofilm growth and decrease in expression of virulence factors associated with burn wound infections.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Article Food Science & Technology

Future of antimicrobial peptides derived from plants in food application-A focus on synthetic peptides

Laila N. Shwaiki et al.

Summary: Synthetic antimicrobial peptides based on plant AMPs are being developed as potential food preservatives, with a focus on enhancing their antimicrobial activity and stability. While the cost of synthesis may be a drawback, advancements in technology may fully exploit the potential role of these synthetic AMPs in combating food spoilage and waste in the long term.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Article Acoustics

Sonodynamic antimicrobial chemotherapy: An emerging alternative strategy for microbial inactivation

Lihua Fan et al.

Summary: Sonodynamic antimicrobial chemotherapy (SACT) combines low-intensity ultrasound with chemotherapeutic agents to effectively combat microbial burden. With its superior penetration ability and high target specificity, SACT has emerged as a promising alternative for microbial inactivation. This treatment method has attracted increasing attention in recent years.

ULTRASONICS SONOCHEMISTRY (2021)

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Review Infectious Diseases

Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK

Nicholas M. Brown et al.

Summary: These evidence-based guidelines are an updated version of those issued in 2008, following a review of literature from 2007-18 on the treatment of MRSA infections. They consider changes in UK MRSA epidemiology and the efficacy of novel anti-staphylococcal agents licensed in the UK, as well as assessing emerging therapies not yet licensed in the UK.

JAC-ANTIMICROBIAL RESISTANCE (2021)

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Article Biodiversity Conservation

What we need to know to prevent a mass extinction of plant species

Stuart L. Pimm

Summary: Human actions are leading to plant extinctions at rates much faster than normal, highlighting the need for a more comprehensive taxonomic catalogue and greater knowledge of plant species distribution. Despite the importance of addressing these questions scientifically, current knowledge is sufficient to implement practical conservation actions, such as protecting biodiversity-rich areas and eliminating non-native species.

PLANTS PEOPLE PLANET (2021)

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Article Pharmacology & Pharmacy

Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents

Khaled AbouAitah et al.

Summary: Nanoformulations using surface-modified metal-organic frameworks show enhanced therapeutic activity and controlled release kinetics for plant-derived natural medicines, particularly rutin and piperine, with improved anti-inflammatory and antioxidant effects compared to their individual components. Single-agent formulations of rutin or piperine exhibit stronger effects than combinations of both agents.

DRUG DELIVERY (2021)

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Review Health Care Sciences & Services

Emerging macrolide resistance in Bordetella pertussis in mainland China: Findings and warning from the global pertussis initiative

Ye Feng et al.

Summary: Whooping cough, caused by Bordetella pertussis, has seen a resurgence in mainland China with the emergence of macrolide-resistant strains. The primary treatment is macrolides, but alternative agents are urgently needed. International surveillance and prevention measures are crucial in preventing the spread of the resistant organism.

LANCET REGIONAL HEALTH-WESTERN PACIFIC (2021)

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Article Chemistry, Multidisciplinary

Biofabricated silver nanoparticles exhibit broad-spectrum antibiofilm and antiquorum sensing activity against Gram-negative bacteria

Faizan Abul Qais et al.

Summary: The study showed that green synthesized silver nanoparticles (AgNPs-MK) demonstrated significant inhibitory effects on biofilm development and quorum sensing controlled virulence factors of Gram negative bacteria, indicating their potential in addressing the issue of antimicrobial resistance.

RSC ADVANCES (2021)

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Article Immunology

Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections

Opeyemi U. Lawal et al.

Summary: Staphylococcus saprophyticus is a major cause of community-acquired UTIs in young women, with evidence suggesting the meat-production chain as a major source of the bacteria causing human UTIs. The pathogenic S. saprophyticus belongs to lineages with distinctive features that are globally and locally disseminated.

EMERGING INFECTIOUS DISEASES (2021)

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Letter Infectious Diseases

Tying the past to the present: time tested knowledge with state-of-the-art technology in the fight against emerging and drug resistant microbes

Reka Szigeti et al.

THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE (2021)

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Article Dentistry, Oral Surgery & Medicine

The antimicrobial and antibiofilm properties of allicin against Candida albicans and Staphylococcus aureus - A therapeutic potential for denture stomatitis

Mukarramah Zainal et al.

Summary: This study demonstrates the therapeutic efficacy of allicin against Candida albicans and Staphylococcus aureus in denture stomatitis, showing significant antimicrobial activity and biofilm eradication potential.

SAUDI DENTAL JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Biocidal mechanism of green synthesized thyme loaded silver nanoparticles (GTAgNPs) against immune evading tricky methicillin-resistant Staphylococcus aureus 090 (MRSA090) at a homeostatic environment

H. M. Manukumar et al.

ARABIAN JOURNAL OF CHEMISTRY (2020)

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Review Chemistry, Physical

Multifaceted Application of Silica Nanoparticles. A Review

Peerzada Gh Jeelani et al.

SILICON (2020)

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Article Chemistry, Analytical

Polyvinyl alcohol/gelatin irradiated blends filled by lignin as green filler for antimicrobial packaging materials

Khaled F. El-Nemr et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY (2020)

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Review Microbiology

It Takes a Village: Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial Biofilms

Giulia Orazi et al.

JOURNAL OF BACTERIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Ultrasound-mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge

Gareth LuTheryn et al.

MICROBIAL BIOTECHNOLOGY (2020)

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Article Oncology

Emergence of Carbapenem-Hydrolyzing Oxacillinases in Acinetobacter baumannii in Children from Croatia

Amarela Lukic-Grlic et al.

CHEMOTHERAPY (2020)

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Article Toxicology

Green synthesis of ZnO nanoparticles with Veronica multifida and their antibiofilm activity

S. Sahin Dogan et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2020)

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Article Chemistry, Inorganic & Nuclear

Effect of Nanoemulsification on the Antibacterial and Anti-biofilm Activities of Selected Spice Essential Oils and Their Major Constituents Against Salmonella enterica Typhimurium

Anand Prakash et al.

JOURNAL OF CLUSTER SCIENCE (2020)

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Article Multidisciplinary Sciences

Green synthesis of silver nanoparticles from Neurada procumbens and its antibacterial activity against multi-drug resistant microbial pathogens

Fahad A. Alharbi et al.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2020)

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Article Pharmacology & Pharmacy

Encapsulation of Red Propolis in Polymer Nanoparticles for the Destruction of Pathogenic Biofilms

Isabelle Souza de Melo Silva et al.

AAPS PHARMSCITECH (2020)

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Article Nanoscience & Nanotechnology

Self-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant Staphylococcus aureus

Xuemei Huang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

Zhang Yuan et al.

ACS NANO (2020)

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Article Chemistry, Physical

Bacteria-nanoparticle interactions in the context of nanofouling

Louise Deschenes et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2020)

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Review Biotechnology & Applied Microbiology

Prevention of biofilm formation by quorum quenching

E. Paluch et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Biofilm Bacteria Use Stress Responses to Detect and Respond to Competitors

Bram Lories et al.

CURRENT BIOLOGY (2020)

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Review Pharmacology & Pharmacy

Flavonoids as Multi-Target Compounds: A Special Emphasis on their Potential as Chemo-adjuvants in Cancer Therapy

Ajay G. Namdeo et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Chemistry, Medicinal

The alarming antimicrobial resistance in ESKAPEE pathogens: Can essential oils come to the rescue?

Zhihui Yu et al.

FITOTERAPIA (2020)

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Article Biochemistry & Molecular Biology

Control of DNA structure and function by phytochemicals/DNA interaction: Resveratrol/piceatannol induces Cu2+-independent, cleavage of supercoiled plasmid DNA

Tze-chen Hsieh et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Infectious Diseases

A penicillin-binding protein that can promote advanced-generation cephalosporin resistance and genome adaptation in the opportunistic pathogen Pseudomonas aeruginosa

Calvin Ho-Fung Lau et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

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Article Microbiology

Naringin sensitizes the antibiofilm effect of ciprofloxacin and tetracycline against Pseudomonas aeruginosa biofilm

Pia Dey et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2020)

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Review Mycology

Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus

P. Chen et al.

JOURNAL DE MYCOLOGIE MEDICALE (2020)

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Article Mycology

Vanillin confers antifungal drug synergism in Candida albicans by impeding CaCdr2p driven efflux

V Saibabu et al.

JOURNAL DE MYCOLOGIE MEDICALE (2020)

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Article Biotechnology & Applied Microbiology

Antimicrobial and antibiofilm activities of ursolic acid against carbapenem-resistant Klebsiella pneumoniae

Weidong Qian et al.

JOURNAL OF ANTIBIOTICS (2020)

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Article Immunology

Antimicrobial, anti-adherence and antibiofilm activity against Staphylococcus aureus of a 4-phenyl coumarin derivative isolated from Brazilian geopropolis

Marcos Guilherme da Cunha et al.

MICROBIAL PATHOGENESIS (2020)

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Article Oncology

Antimicrobial photodynamic therapy against multidrug-resistant Acinetobacter baumannii clinical isolates mediated by aloe-emodin: An in vitro study

Jiao Li et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2020)

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Article Biochemistry & Molecular Biology

Polyherbal drug loaded starch nanoparticles as promising drug delivery system: Antimicrobial, antibiofilm and neuroprotective studies

Prakashkumar Nallasamy et al.

PROCESS BIOCHEMISTRY (2020)

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Review Acoustics

SONOBACTERICIDE: AN EMERGING TREATMENT STRATEGY FOR BACTERIAL INFECTIONS

Kirby R. Lattwein et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2020)

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Article Pharmacology & Pharmacy

Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination

Xuehao Tian et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Pharmacology & Pharmacy

Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections

Barbara Giordani et al.

PHARMACEUTICS (2020)

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Review Pharmacology & Pharmacy

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Nermin E. Eleraky et al.

PHARMACEUTICS (2020)

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Article Microbiology

Chrysin-Loaded Chitosan Nanoparticles Potentiates Antibiofilm Activity against Staphylococcus aureus

Busi Siddhardha et al.

PATHOGENS (2020)

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Article Multidisciplinary Sciences

Homalomena pineodora essential oil nanoparticle inhibits diabetic wound pathogens

Nur Amiera Syuhada Rozman et al.

SCIENTIFIC REPORTS (2020)

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Article Multidisciplinary Sciences

Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria

Claes Sondergaard Wassmann et al.

SCIENTIFIC REPORTS (2020)

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Article Biotechnology & Applied Microbiology

High synergistic antibacterial, antibiofilm, antidiabetic and antimetabolic activity ofWithania somniferaleaf extract-assisted zinc oxide nanoparticle

Balasubramanian Malaikozhundan et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2020)

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Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with Pseudomonas aeruginosa

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Green synthesis and biological activities of gold nanoparticles functionalized with Salix alba

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Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection

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Inhibitory Effects of Honokiol and Magnolol on Biofilm Formation by Acinetobacter baumannii

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Biogenic synthesis of iron oxide nanoparticles via Skimmia laureola and their antibacterial efficacy against bacterial wilt pathogen Ralstonia solanacearum

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Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications

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Daphnetin prevents methicillin-resistant Staphylococcus aureus infection by inducing autophagic response

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Carvacrol and astaxanthin co-entrapment in beeswax solid lipid nanoparticles as an efficient nano-system with dual antioxidant and anti-biofilm activities

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Inhibitory Effect of Two Traditional Chinese Medicine Monomers, Berberine and Matrine, on the Quorum Sensing System of Antimicrobial-Resistant Escherichia coli

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Biogenic fabrication of gold nanoparticles using Camellia japonica L. leaf extract and its biological evaluation

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Nanoemulsions of Green Tea Catechins and Other Natural Compounds for the Treatment of Urinary Tract Infection: Antibacterial Analysis

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Efficacy of Biogenic Selenium Nanoparticles from an Extract of Ginger towards Evaluation on Anti-Microbial and Anti-Oxidant Activities

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ROS mediated destruction of cell membrane, growth and biofilms of human bacterial pathogens by stable metallic AgNPs functionalized from bell pepper extract and quercetin

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Diallyl disulfide from garlic oil inhibits Pseudomonas aeruginosa virulence factors by inactivating key quorum sensing genes

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Chitosan nanoencapsulation of flavonoids enhances their quorum sensing and biofilm formation inhibitory activities against an E.coli Top 10 biosensor

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Combined effect of a natural flavonoid rutin from Citrus sinensis and conventional antibiotic gentamicin on Pseudomonas aeruginosa biofilm formation

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The antibacterial activity of clove oil/chitosan nanoparticles embedded gelatin nanofibers against Escherichia coli O157:H7 biofilms on cucumber

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Green synthesis of copper nanoparticles by fruit extract of Ziziphus spina-christi (L) Willd.: Application for adsorption of triphenylmethane dye and antibacterial assay

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Green synthesis of iron nanoparticles using Moringa oleifera extracts and their applications: Removal of nitrate from water and antibacterial activity against Escherichia coli

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Biogenic synthesis, characterization and antibacterial activity of gold nanoparticles synthesised from vegetable waste

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Antibacterial and anti-biofilm activity of nanoemulsion of Thymus daenensis oil against multi-drug resistant Acinetobacter baumannii

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Biogenic synthesis of CuO nanoparticles using Bauhinia tomentosa leaves extract: Characterization and its antibacterial application

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Biofabrication of Zinc Oxide Nanoparticle from Ochradenus baccatus Leaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, and In Vivo Toxicity and Stress Studies

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Synthesis of NiO nanoparticles via a green route using Monsonia burkeana: The physical and biological properties

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Biogenic synthesis of iron oxide nanoparticles using Agrewia optiva and Prunus persica phyto species: Characterization, antibacterial and antioxidant activity

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Green synthesis of NiO nanoparticles using Aegle marmelos leaf extract for the evaluation of in-vitro cytotoxicity, antibacterial and photocatalytic properties

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Biosynthesis of iron nanoparticles using Trigonella foenum-graecum seed extract for photocatalytic methyl orange dye degradation and antibacterial applications

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Solid lipid nanoparticles carrying Eugenia caryophyllata essential oil: the novel nanoparticulate systems with broad-spectrum antimicrobial activity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Biochemistry & Molecular Biology

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Vertically Aligned Graphene Coating is Bactericidal and Prevents the Formation of Bacterial Biofilms

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The Influence of Shuttle-Shape Emodin Nanoparticles on the Streptococcus suis Biofilm

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Green synthesis of copper oxide nanoparticles and its effective applications in Biginelli reaction, BTB photodegradation and antibacterial activity

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In Silico Models for Nanomedicine: Recent Developments

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CURRENT MEDICINAL CHEMISTRY (2018)

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Silica-gentamicin nanohybrids: combating antibiotic resistance, bacterial biofilms, and in vivo toxicity

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Antimicrobial photodynamic activity of rose bengal conjugated multi walled carbon nanotubes against planktonic cells and biofilm of Escherichia coli

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PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2018)

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Article Biotechnology & Applied Microbiology

Antifungal activity of magnoflorine against Candida strains

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WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2018)

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Candida-streptococcal interactions in biofilm-associated oral diseases

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PLOS PATHOGENS (2018)

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Biosynthesis of Ag nanoparticles using Cynara cardunculus leaf extract: Evaluation of their antibacterial and electrochemical activity

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Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention

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Role of plant alkaloids on human health: A review of biological activities

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Biosynthesis and characterization of iron oxide nanoparticles using Eichhornia crassipes leaf extract and assessing their antibacterial activity

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An overview of the antimicrobial resistance mechanisms of bacteria

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Chronic tonsillitis and biofilms: a brief overview of treatment modalities

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Cross-Linked Polymer-Stabilized Nanocomposites for the Treatment of Bacteria Biofilms

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Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment

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ACTA PHARMACOLOGICA SINICA (2017)

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EXPERT OPINION ON DRUG DELIVERY (2017)

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Role of Medicinal Plants for Liver-Qi Regulation Adjuvant Therapy in Post-stroke Depression: A Systematic Review of Literature

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Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Bifunctional viscous nanovesicles co-loaded with resveratrol and gallic acid for skin protection against microbial and oxidative injuries

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A plant-derived dehydrorotenoid: a new inhibitor of hepatitis C virus entry

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Rutin inhibits mono and multi-species biofilm formation by foodborne drug resistant Escherichia coli and Staphylococcus aureus

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Management of Antiviral Resistance in Chronic Hepatitis B

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Bacterial and Fungal Biofilm formation on Contact Lenses and their Susceptibility to Lens Care Solutions

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Effect of the deacetylation degree on the antibacterial and antibiofilm activity of acemannan from Aloe vera

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Essential oil nanoemulsions of wild patchouli attenuate multi-drug resistant gram-positive, gram-negative and Candida albicans

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Antimicrobial activity of free and liposome-encapsulated thymol and carvacrol against Salmonella and Staphylococcus aureus adhered to stainless steel

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INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2017)

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Article Pharmacology & Pharmacy

Bioactive mesoporous silica nanostructures with anti-microbial and anti-biofilm properties

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Investigation of the antifungal potential of linalool against clinical isolates of fluconazole resistant Trichophyton rubrum

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Potentiation of antibiotic against Pseudomonas aeruginosa biofilm: a study with plumbagin and gentamicin

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Decreased Bacterial Adherence, Biofilm Formation, and Tissue Reactivity of Barbed Monofilament Suture in an In Vivo Contaminated Wound Model

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Article Biotechnology & Applied Microbiology

Antibiofilm and Anti-β-Lactamase Activities of Burdock Root Extract and Chlorogenic Acid against Klebsiella pneumoniae

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Green synthesis, characterization and antibacterial efficacy of palladium nanoparticles synthesized using Filicium decipiens leaf extract

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Facile and green synthesis of phytochemicals capped platinum nanoparticles and in vitro their superior antibacterial activity

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Effects of Surface Charges on the Bactericide Activity of CdTe/ZnS Quantum Dots: A Cell Membrane Disruption Perspective

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The antioxidant, antibacterial, antibiofilm activity of essential oil from Citrus medica L. var. sarcodactylis and its nanoemulsion

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LWT-FOOD SCIENCE AND TECHNOLOGY (2017)

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Multifunctional biosynthesized silver nanoparticles exhibiting excellent antimicrobial potential against multi-drug resistant microbes along with remarkable anticancerous properties

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Synthesis of phytochemicals-stabilized gold nanoparticles and their biological activities against bacteria and Leishmania

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Melaleuca alternifolia nanoparticles against Candida species biofilms

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Antimicrobial and antibiofilm activities of nanoemulsions containing Eucalyptus globulus oil against Pseudomonas aeruginosa and Candida spp.

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Antimicrobial activity of Melaleuca alternifolia nanoparticles in polymicrobial biofilm in situ

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MICROBIAL PATHOGENESIS (2017)

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Antibiofilm activity of nanoemulsions of Cymbopogon flexuosus against rapidly growing mycobacteria

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MICROBIAL PATHOGENESIS (2017)

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Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from Justicia glauca against oral pathogens: A nanoantibiotic approach

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Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity

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MICROBIOLOGICAL RESEARCH (2017)

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Inibitory effects of linalool on fungal pathogenicity of clinical isolates of Microsporum canis and Microsporum gypseum

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The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice

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Review Microbiology

Targeting microbial biofilms: current and prospective therapeutic strategies

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NATURE REVIEWS MICROBIOLOGY (2017)

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Sonodynamic therapy, a treatment developing from photodynamic therapy

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PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2017)

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Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria

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Bacterial biofilms in the vagina

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RESEARCH IN MICROBIOLOGY (2017)

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Pseudomonas aeruginosa Alters Staphylococcus aureus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection

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MBIO (2017)

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The antibacterial and antibiofilm efficacies of a liposomal peptide originating from rice bran protein against Listeria monocytogenes

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FOOD & FUNCTION (2017)

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Evaluation of Antimicrobial Durability and Anti-Biofilm Effects in Urinary Catheters Against Enterococcus faecalis Clinical Isolates and Reference Strains

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BALKAN MEDICAL JOURNAL (2017)

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Article Biotechnology & Applied Microbiology

Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort

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BIOMED RESEARCH INTERNATIONAL (2017)

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Curcumin Quantum Dots Mediated Degradation of Bacterial Biofilms

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FRONTIERS IN MICROBIOLOGY (2017)

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The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice

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NANOSCALE RESEARCH LETTERS (2017)

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Review Chemistry, Multidisciplinary

Environmental impact and potential health risks of 2D nanomaterials

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ENVIRONMENTAL SCIENCE-NANO (2017)

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Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

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NATURE MICROBIOLOGY (2017)

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Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis

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SCIENTIFIC REPORTS (2017)

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Development of Nanoemulsion Based Gel Loaded with Phytoconstituents for the Treatment of Urinary Tract Infection and in Vivo Biodistribution Studies

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ADVANCED PHARMACEUTICAL BULLETIN (2017)

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Direct one-pot synthesis of cinnamaldehyde immobilized on gold nanoparticles and their antibiofilm properties

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Article Biotechnology & Applied Microbiology

Synthesis and characterization of biogenic iron oxide nanoparticles using green chemistry approach and evaluating their biological activities

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BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2017)

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CLINICAL OTOLARYNGOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Biogenic gold nanoparticles synthesized using Crescentia cujete L. and evaluation of their different biological activities

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BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2017)

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Proteases, actinidin, papain and trypsin reduce oral biofilm on the tongue in elderly subjects and in vitro

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ARCHIVES OF ORAL BIOLOGY (2017)

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Review Integrative & Complementary Medicine

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Article Biotechnology & Applied Microbiology

Aloe-emodin inhibits Staphylococcus aureus biofilms and extracellular protein production at the initial adhesion stage of biofilm development

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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)

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Hydrophobin coating prevents Staphylococcus epidermidis biofilm formation on different surfaces

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BIOFOULING (2017)

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Anti biofilm effect of dihydromyricetin-loaded nanocapsules on urinary catheter infected by Pseudomonas aeruginosa

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COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells

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BIOORGANIC & MEDICINAL CHEMISTRY (2017)

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Role of Biofilm in Cerebrospinal Fluid Shunt Infections: A Study at Tertiary Neurocare Center from South India

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JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE (2017)

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Biofilm-mediated Antibiotic-resistant Oral Bacterial Infections: Mechanism and Combat Strategies

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CURRENT PHARMACEUTICAL DESIGN (2017)

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Insights on Klebsiella pneumoniae Biofilms Assembled on Different Surfaces Using Phenotypic and Genotypic Approaches

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MICROORGANISMS (2017)

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Article Biotechnology & Applied Microbiology

In vitro activity of alpha-mangostin in killing and eradicating Staphylococcus epidermidis RP62A biofilms

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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)

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Review Tropical Medicine

Nosocomial infections: Epidemiology, prevention, control and surveillance

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ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2017)

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Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

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FEMS MICROBIOLOGY REVIEWS (2017)

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Vancomycin resistant Enterococcus faecium(VRE) vertebral osteomyelitis after uneventful spinal surgery: A case report and literature review

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INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT (2017)

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Review Immunology

Orthopaedic biofilm infections

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APMIS (2017)

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Review Immunology

Dental biofilm infections - an update

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APMIS (2017)

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A short history of microbial biofilms and biofilm infections

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Central venous catheters and biofilms: where do we stand in 2017?

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Regulatory Aspects of Nanomaterials in the EU

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Microbial Biofilms and Chronic Wounds

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MICROORGANISMS (2017)

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Article Microbiology

Impairment of Pseudomonas aeruginosa Biofilm Resistance to Antibiotics by Combining the Drugs with a New Quorum-Sensing Inhibitor

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

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Biofilm, pathogenesis and prevention-a journey to break the wall: a review

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ARCHIVES OF MICROBIOLOGY (2016)

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Intravenous administration of silver nanoparticles causes organ toxicity through intracellular ROS-related loss of inter-endothelial junction

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PARTICLE AND FIBRE TOXICOLOGY (2016)

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Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi

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APPLIED NANOSCIENCE (2016)

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Article Biotechnology & Applied Microbiology

Liposome containing cinnamon oil with antibacterial activity against methicillin-resistant Staphylococcus aureus biofilm

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BIOFOULING (2016)

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Comparative analysis of the relative potential of silver, Zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis

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CANCER LETTERS (2016)

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Contribution of reactive oxygen species to (+)-catechin-mediated bacterial lethality

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CHEMICO-BIOLOGICAL INTERACTIONS (2016)

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Review Infectious Diseases

Microbiome, biofilms, and pneumonia in the ICU

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CURRENT OPINION IN INFECTIOUS DISEASES (2016)

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Membrane interactions of mesoporous silica nanoparticles as carriers of antimicrobial peptides

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Photocatalytic and antibacterial response of biosynthesized gold nanoparticles

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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2016)

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Streptococcus mutans biofilm transient viscoelastic fluid behaviour during high-velocity microsprays

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JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2016)

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Multidrug-Resistant Gram-Negative Bacterial Infections in the Hospital Setting: Overview, Implications for Clinical Practice, and Emerging Treatment Options

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MICROBIAL DRUG RESISTANCE (2016)

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Nanocapsules with glycerol monolaurate: Effects on Candida albicans biofilms

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MICROBIAL PATHOGENESIS (2016)

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Anti-Candida activity assessment of Pelargonium graveolens oil free and nanoemulsion in biofilm formation in hospital medical supplies

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Influence of Melaleuca alternifolia oil nanoparticles on aspects of Pseudomonas aeruginosa biofilm

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MICROBIAL PATHOGENESIS (2016)

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Anti-bacterial and anti-biofilm activity of probiotic bacteria against oral pathogens

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MICROBIAL PATHOGENESIS (2016)

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Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance

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Incorporation of Farnesol Significantly Increases the Efficacy of Liposomal Ciprofloxacin against Pseudomonas aeruginosa Biofilms in Vitro

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MOLECULAR PHARMACEUTICS (2016)

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Article Biochemistry & Molecular Biology

Antimicrobial Lemongrass Essential Oil-Copper Ferrite Cellulose Acetate Nanocapsules

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Bacterial physiology is a key modulator of the antibacterial activity of graphene oxide

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NANOSCALE (2016)

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The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms

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Review Chemistry, Multidisciplinary

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

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PHARMACEUTICAL RESEARCH (2016)

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Effects of different surface modifying agents on the cytotoxic and antimicrobial properties of ZnO nanoparticles

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TOXICOLOGY IN VITRO (2016)

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Antifungal and antibacterial activities of allicin: A review

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TRENDS IN FOOD SCIENCE & TECHNOLOGY (2016)

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Synthesis of Self-Assembled Spermidine-Carbon Quantum Dots Effective against Multidrug-Resistant Bacteria

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Revised Estimates for the Number of Human and Bacteria Cells in the Body

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PLOS BIOLOGY (2016)

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Neem leaves mediated preparation of NiO nanoparticles and its magnetization, coercivity and antibacterial analysis

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RESULTS IN PHYSICS (2016)

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Deciphering the Contribution of Biofilm to the Pathogenesis of Peritoneal Dialysis Infections: Characterization and Microbial Behaviour on Dialysis Fluids

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Role of Berberine in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

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SCIENTIFIC REPORTS (2016)

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Polylactic Acid-Lemongrass Essential Oil Nanocapsules with Antimicrobial Properties

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Biofilm in group A streptococcal necrotizing soft tissue infections

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JCI INSIGHT (2016)

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Shape-Dependent Biomimetic Inhibition of Enzyme by Nanoparticles and Their Antibacterial Activity

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ACS NANO (2015)

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Prevention of cell-surface attachment and reduction of penicillin-binding protein 2a (PBP2a) level in methicillin-resistant Staphylococcus aureus biofilms by Acalypha wilkesiana

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BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

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High prevalence of oxacillinases in clinical multidrug-resistant Acinetobacter baumannii isolates from the Tshwane region, South Africa - an update

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Independent effect of polymeric nanoparticle zeta potential/surface charge, ontheir cytotoxicity and affinity to cells

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CELL PROLIFERATION (2015)

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A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

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COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: Formulation, characterisation and functionalisation with dornase alfa (DNase)

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Antimicrobial-related medication safety incidents: a regional retrospective study in West of Scotland hospitals

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Rosmarinus officinalis leaf extract mediated green synthesis of silver nanoparticles and investigation of its antimicrobial properties

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Review Otorhinolaryngology

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Patterns of Candida biofilm on intrauterine devices

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Studies on catalytic, antioxidant, antibacterial and anticancer activities of biogenic gold nanoparticles

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NATURE REVIEWS MICROBIOLOGY (2015)

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Cannabinoids: structures, effects, and classification

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Review Orthopedics

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Effect of Cinnamon Oil on Quorum Sensing-Controlled Virulence Factors and Biofilm Formation in Pseudomonas aeruginosa

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Review Dentistry, Oral Surgery & Medicine

Biofilm in endodontics: A review

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CURRENT DRUG TARGETS (2014)

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Antibiotic-free nanotherapeutics: Ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors

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Shape-dependent bactericidal activity of copper oxide nanoparticle mediated by DNA and membrane damage

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Antimicrobial nanospheres thin coatings prepared by advanced pulsed laser technique

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Effects of Particle Size and Surface Modification on Cellular Uptake and Biodistribution of Polymeric Nanoparticles for Drug Delivery

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Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective

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Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria

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DRUG RESISTANCE UPDATES (2012)

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Carbon nanotube-based antimicrobial biomaterials formed via layer-by-layer assembly with polypeptides

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Platelets Enhance Biofilm Formation and Resistance of Endocarditis-Inducing Streptococci on the Injured Heart Valve

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High Levels of Genetic Recombination during Nasopharyngeal Carriage and Biofilm Formation in Streptococcus pneumoniae

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Chemical synthesis and antibacterial activity of novel-shaped silver nanoparticles

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Effective functionalization of multiwalled carbon nanotube with amphiphilic poly(propyleneimine) dendrimer carrying silver nanoparticles for better dispersability and antimicrobial activity

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Cooperative antimicrobial activity of CdTe quantum dots with rocephin and fluorescence monitoring for Escherichia coli

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Editorial Material Microbiology

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[Anonymous]

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ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2011)

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Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease

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Electronic-Structure-Dependent Bacterial Cytotoxicity of Single-Walled Carbon Nanotubes

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Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis

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Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

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ADVANCED DRUG DELIVERY REVIEWS (2009)

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Outer membrane permeability and antibiotic resistance

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Development of an oral rutin nanocrystal formulation

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Article Biochemistry & Molecular Biology

PBP Active Site Flexibility as the Key Mechanism for β-Lactam Resistance in Pneumococci

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Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies

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JOURNAL OF NANOPARTICLE RESEARCH (2009)

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Review Biochemistry & Molecular Biology

Polymeric Plant-derived Excipients in Drug Delivery

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MOLECULES (2009)

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Review Nanoscience & Nanotechnology

Drug delivery and nanoparticles: Applications and hazards

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2008)

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Review Chemistry, Medicinal

Antiviral Activity of Phytochemicals: A Comprehensive Review

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MINI-REVIEWS IN MEDICINAL CHEMISTRY (2008)

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Review Biotechnology & Applied Microbiology

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

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NANOMEDICINE (2008)

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Review Biochemistry & Molecular Biology

Reconciling the chemistry and biology of reactive oxygen species

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Article Biotechnology & Applied Microbiology

Renal clearance of quantum dots

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NATURE BIOTECHNOLOGY (2007)

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Review Microbiology

Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties

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CLINICAL MICROBIOLOGY REVIEWS (2006)

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The bactericidal effect of silver nanoparticles

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NANOTECHNOLOGY (2005)

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Review Biochemistry & Molecular Biology

Antibacterial resistance worldwide: causes, challenges and responses

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NATURE MEDICINE (2004)

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Article Microbiology

Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus

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JOURNAL OF CLINICAL MICROBIOLOGY (2003)

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Article Pharmacology & Pharmacy

Liposome clearance in mice: the effect of a separate and combined presence of surface charge and polymer coating

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2002)

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Article Biochemistry & Molecular Biology

Interference of serum with lipoplex-cell interaction: modulation of intracellular processing

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)

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Article Biotechnology & Applied Microbiology

Cellular impermeability and uptake of biocides and antibiotics in Gram-positive bacteria and mycobacteria

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JOURNAL OF APPLIED MICROBIOLOGY (2002)

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Article Microbiology

Imipenem resistance of Enterobacter aerogenes mediated by outer membrane permeability

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JOURNAL OF CLINICAL MICROBIOLOGY (2000)

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