4.6 Article

Mutational scanning identified amino acids of the CLOCK exon 19-domain essential for circadian rhythms

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells

Linlin Tian et al.

Summary: The study showed that CLOCK is abundantly expressed in rat pancreatic beta cells, and its knockdown significantly affects insulin secretion. The potential pathway of CLOCK mediating Cav1.2 expression may play a crucial role in regulating insulin secretion.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Review Physiology

Mammalian circadian systems: Organization and modern life challenges

Anna-Marie Finger et al.

Summary: The endogenous circadian clock system in humans and other mammals is crucial for health, but modern lifestyles with artificial lighting, shift work, and travel across time zones can disrupt this system and lead to associated diseases. This review highlights the importance of a functional clock machinery and alignment between body clocks, as well as the impact of circadian disruption on health.

ACTA PHYSIOLOGICA (2021)

Article Multidisciplinary Sciences

Molecular mechanism of the repressive phase of the mammalian circadian clock

Xuemei Cao et al.

Summary: The mammalian circadian clock is regulated by a transcription-translation feedback loop involving CLOCK-BMAL1 activators and CRY-PER repressors. Previous studies have shown that CRY and CRY-PER inhibit CLOCK-BMAL1 in different mechanisms. This study reveals the involvement of CRY-PER in displacing CLOCK-BMAL1 by recruiting CK1 delta, leading to the dissociation of CLOCK-BMAL1 from the E-box.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Biochemistry & Molecular Biology

Coupled network of the circadian clocks: a driving force of rhythmic physiology

Anna-Marie Finger et al.

FEBS LETTERS (2020)

Article Physiology

Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology

Teresa Boerding et al.

FRONTIERS IN PHYSIOLOGY (2019)

Editorial Material Physiology

Good publication practice in physiology 2019

Pontus B. Persson

ACTA PHYSIOLOGICA (2019)

Article Biochemistry & Molecular Biology

Macromolecular Assemblies of the Mammalian Circadian Clock

Rajindra P. Aryal et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor

Zhiqiang Hou et al.

STRUCTURE (2017)

Article Biochemistry & Molecular Biology

Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder

Alina Patke et al.

Article Multidisciplinary Sciences

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

Euna Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biotechnology & Applied Microbiology

Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Maximilian Haeussler et al.

GENOME BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Cancer/Testis Antigen PASD1 Silences the Circadian Clock

Alicia K. Michael et al.

MOLECULAR CELL (2015)

Letter Biochemical Research Methods

Improved vectors and genome-wide libraries for CRISPR screening

Neville E. Sanjana et al.

NATURE METHODS (2014)

Review Cell Biology

Molecular architecture of the mammalian circadian clock

Carrie L. Partch et al.

TRENDS IN CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Machine Learning Helps Identify CHRONO as a Circadian Clock Component

Ron C. Anafi et al.

PLOS BIOLOGY (2014)

Article Biochemistry & Molecular Biology

A mutation in CLOCK leads to altered dopamine receptor function

Sade Spencer et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

Hikari Yoshitane et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Neurosciences

CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Jason P. DeBruyne et al.

NATURE NEUROSCIENCE (2007)

Article Cell Biology

CIPC is a mammalian circadian clock protein without invertebrate homologues

Wen-Ning Zhao et al.

NATURE CELL BIOLOGY (2007)

Article Multidisciplinary Sciences

Obesity and metabolic syndrome in circadian Clock mutant mice

FW Turek et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

JP Etchegaray et al.

NATURE (2003)

Article Multidisciplinary Sciences

Dec1 and Dec2 are regulators of the mammalian molecular clock

S Honma et al.

NATURE (2002)