期刊
ACTA PHYSIOLOGICA
卷 234, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/apha.13769
关键词
blood flow restriction; cholesterol; exercise; glucose transport; hypoxia; insulin sensitivity
类别
This study found that independent of muscle hypoxia level, BFR exercise enhances early markers of metabolic health associated with cholesterol synthesis regulation and glucose homeostasis.
Aim: This study examined whether aerobic-interval exercise with blood flow restriction (BFR) potentiates early markers of metabolic health compared to exercise with systemic hypoxia or normoxia in man. Methods: In a randomized-crossover fashion, eight healthy men completed nine 2-minute running bouts at 105% of their lactate threshold on three occasions separated by one week, either with BFR (BFR-trial), systemic hypoxia (HYP-trial) or normoxia (control; CON-trial). Near-infrared spectroscopy was used to assess the muscle level of hypoxia. A muscle biopsy was collected at rest and 3 hours after exercise to quantify genes involved in cholesterol synthesis (PGC-1 alpha 2), glucose disposal (GLUT4) and capillary growth (HIF-1 alpha; VEGFA), as well as mitochondrial respiration (PGC-1 alpha 2/3), uncoupling (UCP3) and expansion (p53; COXIV-1/2; CS; AMPK alpha 1/2). Results: The muscle level of hypoxia was matched between the BFR-trial and HYP-trial (similar to 90%; P > .05), which was greater than the CON-trial (similar to 70%; P < .05). PGC-1 alpha 2 increased most in the BFR-trial (16-fold vs CON-trial; 11-fold vs HYP-trial; P < .05). GLUT4 and VEGFA selectively increased by 2.0 and 3.4-fold, respectively in BFR-trial (P < .05), which was greater than CON-trial (1.2 and 1.3 fold) and HYP-trial (1.2 and 1.8 fold; P < .05). UCP3 increased more in BFR-trial than the HYP-trial (4.3 vs 1.6 fold), but was not different between BFR-trial and CON-trial (2.1 fold) or between CON-trial and HYP-trial (P > .05). No trial differences were evident for other genes (P > .05). Conclusion: Independent of the muscle level of hypoxia, BFR-exercise potentiates early markers of metabolic health associated with the regulation of cholesterol production and glucose homeostasis in man.
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