4.7 Article

Connexin 43 hyper-phosphorylation at serine 282 triggers apoptosis in rat cardiomyocytes via activation of mitochondrial apoptotic pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders

Xun Ai et al.

Summary: This review focuses on the regulation of Cx43 phosphorylation state and cell-to-cell communication by serine-threonine protein phosphatases, and their impact on arrhythmogenesis in chronic heart failure, myocardial ischemia, and atrial fibrillation. The therapeutic potential of modulating protein phosphatases to treat arrhythmias in these clinical settings is also discussed.

CELLULAR SIGNALLING (2021)

Article Multidisciplinary Sciences

Cardiac macrophages prevent sudden death during heart stress

Junichi Sugita et al.

Summary: It has been demonstrated that cardiac resident macrophages are crucial regulators of cardiac impulse conduction through the production of Amphiregulin, contributing significantly to the prevention of sudden death.

NATURE COMMUNICATIONS (2021)

Article Cardiac & Cardiovascular Systems

Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia

Zhipeng Sun et al.

Summary: Casq1 is expressed in the heart, where it regulates sarcoplasmic reticulum Ca2+ release and heart rate. Casq1 deficiency independently causes MH/EHS-like ventricular arrhythmia by trigger-induced Casq1 oligomerization and a relief of its inhibitory effect on ryanodine receptor-2-mediated Ca2+ release, thus revealing a new inherited arrhythmia and a novel mechanism for MH/EHS arrhythmogenesis.

CIRCULATION (2021)

Article Medicine, Research & Experimental

Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure

Liu Yang et al.

Summary: The experiment shows that the deletion of Miat can alleviate pathological cardiac hypertrophy and heart failure, mainly by enhancing the contractility of cardiomyocytes.

THERANOSTICS (2021)

Review Pharmacology & Pharmacy

Mechanisms for the transition from physiological to pathological cardiac hypertrophy

Christopher J. Oldfield et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy

Eric Himelman et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Cardiac & Cardiovascular Systems

EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases

Tania Martins-Marques et al.

CIRCULATION RESEARCH (2020)

Article Biochemistry & Molecular Biology

Connexin43 dephosphorylation at serine 282 is associated with connexin43-mediated cardiomyocyte apoptosis

Yutong Yang et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Biochemistry & Molecular Biology

Connexin 43-serine 282 modulates serine 279 phosphorylation in cardiomyocytes

Zhipeng Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Cardiac & Cardiovascular Systems

Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia/reperfusion hearts

Jingyi Xue et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

Article Biochemistry & Molecular Biology

The connexin 43 C-terminus: A tail of many tales

Edward Leithe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

Review Cardiac & Cardiovascular Systems

Regulation of cardiac gap junctions by protein phosphatases

Ashleigh R. Hood et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Newly Identified NO-Sensor Guanylyl Cyclase/Connexin 43 Association Is Involved in Cardiac Electrical Function

Pierre-Antoine Crassous et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

Article Cell Biology

Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia

John J. Kelly et al.

MOLECULAR BIOLOGY OF THE CELL (2016)

Article Cardiac & Cardiovascular Systems

The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent

Wattamon Srisakuldee et al.

CARDIOVASCULAR RESEARCH (2014)

Review Biochemistry & Molecular Biology

Specific Cx43 phosphorylation events regulate gap junction turnover in vivo

Joell L. Solan et al.

FEBS LETTERS (2014)

Review Biochemistry & Molecular Biology

Connexin43 phosphorylation and cytoprotection in the heart

Maya M. Jeyaraman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)

Article Cardiac & Cardiovascular Systems

Phosphatase-Resistant Gap Junctions Inhibit Pathological Remodeling and Prevent Arrhythmias

Benjamin F. Remo et al.

CIRCULATION RESEARCH (2011)

Article Cardiac & Cardiovascular Systems

Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro

Tepmanas Bupha-Intr et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Review Biochemistry & Molecular Biology

Connexin43 phosphorylation: structural changes and biological effects

Joell L. Solan et al.

BIOCHEMICAL JOURNAL (2009)

Article Cardiac & Cardiovascular Systems

Gap Junction Remodeling and Spironolactone-Dependent Reverse Remodeling in the Hypertrophied Heart

Jiaxiang Qu et al.

CIRCULATION RESEARCH (2009)

Article Cardiac & Cardiovascular Systems

Phosphorylation of connexin43 on serine 306 regulates electrical coupling

Kristina Procida et al.

HEART RHYTHM (2009)

Article Medicine, Research & Experimental

α1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice

Hiroyuki Nakayama et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Cell Biology

Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart

Paul D. Lampe et al.

JOURNAL OF CELL SCIENCE (2006)

Article Chemistry, Multidisciplinary

Role of inositol 1,4,5-trisphosphate receptors in α1-adrenergic receptor-induced cardiomyocyte hypertrophy

Da-li Luo et al.

ACTA PHARMACOLOGICA SINICA (2006)