Acute Generalized Exanthematous Pustulosis in Close Temporal Association with mRNA-1273 Vaccine

Article Dermatology

Clinical presentation and management of atypical and recalcitrant acute generalized exanthematous pustulosis

Mohammad Amin Hadavand et al.

Summary: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction characterized by nonfollicular pustules on a red base that develop rapidly after drug exposure. It is caused by cytokines produced by drug-specific T cells that mediate neutrophilic pustule formation. Individuals with IL-36RN mutations may have an increased risk of developing AGEP. The condition typically presents with leukocytosis and fever during the acute pustular phase, followed by a self-limited recovery phase after stopping the offending drug. Severe cases may involve multiple organ systems.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

添加到收藏夹

Article Dermatology

Acute Generalized Exanthematous Pustulosis (AGEP) in 12 Patients Treated for SARS-CoV-2 Positive Pneumonia

Enrico Pezzarossa et al.

Summary: This study describes 12 patients with SARS-CoV-2 pneumonia who developed an acute erythematous rash with nonfollicular pinhead-sized pustules. They were treated with systemic corticosteroids and showed improvement after several days. AGEP is classified as a severe cutaneous adverse reaction typically resolving spontaneously in less than 15 days. Recognizing AGEP is crucial to avoid confusion with systemic infections and prevent incorrect treatments.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2021)

添加到收藏夹

Review Dermatology

A systematic review on treatment-related mucocutaneous reactions in COVID-19 patients

Niloufar Najar Nobari et al.

Summary: Most drugs, including COVID-19 medications, can cause mucocutaneous reactions. The interval between drug usage and the eruption varies depending on the drug type, with hydroxychloroqine having the longest mean interval. Antivirals, antimalarials, azithromycin, and tocilizumab are the most responsive drugs for adverse reactions. Different drugs have different rates of dermatologic adverse effects, potentially leading to life-threatening reactions in rare cases.

DERMATOLOGIC THERAPY (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

COVID-19 vaccine-induced acute generalized exanthematous pustulosis

Sung-Yoon Kang et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2021)

添加到收藏夹

Review Dermatology

Acute generalized exanthematous pustulosis (AGEP): A review and update

Jesse Szatkowski et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

添加到收藏夹

Article Dermatology

The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis

Sylvia H. Kardaun et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2010)

添加到收藏夹

Article Dermatology

Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature

HS Beltraminelli et al.

BRITISH JOURNAL OF DERMATOLOGY (2005)

添加到收藏夹

Acute Generalized Exanthematous Pustulosis in Close Temporal Association with mRNA-1273 Vaccine

相关参考文献

Clinical presentation and management of atypical and recalcitrant acute generalized exanthematous pustulosis

Acute Generalized Exanthematous Pustulosis (AGEP) in 12 Patients Treated for SARS-CoV-2 Positive Pneumonia

A systematic review on treatment-related mucocutaneous reactions in COVID-19 patients

COVID-19 vaccine-induced acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis (AGEP): A review and update

The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis

Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature

导出引文

分享论文