Titanium carbide MXene-based hybrid hydrogel for chemo-photothermal combinational treatment of localized bacterial infection

Article Engineering, Biomedical

Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis

Kuo-Yang Sun et al.

Summary: This study develops few-layered Nb2C (FNC) as an antioxidant that decreases cytokine production and inhibits osteoclastogenesis to alleviate prosthesis-induced osteolysis.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Medicinal

Modular Design of Membrane-Active Antibiotics: From Macromolecular Antimicrobials to Small Scorpionlike Peptidomimetics

Minghui Wang et al.

Summary: A new class of small amphiphilic scorpionlike peptidomimetics were designed based on bioengineering, showing potent antimicrobial activity against both Gram-positive and Gram-negative bacteria without drug resistance. In vivo experiments demonstrated the lead compound's impressive therapeutic efficacy in treating MRSA infections, with a significantly higher bactericidal efficiency compared to ciprofloxacin. These results highlight the potential of these HDP mimics as novel antibiotic therapeutics.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Poloxamer/Poly(ethylene glycol) Self-Healing Hydrogel for High-Precision Freeform Reversible Embedding of Suspended Hydrogel

Arthur Colly et al.

Summary: The study introduces a new support hydrogel bath formulation for FRESH 3D printing, enhancing the accuracy and resolution of printed soft materials. It was found that increasing yield stress improves print accuracy but limits self-healing ability, leading to crevasse formation. The tunable hydrogel demonstrated its usefulness in manufacturing parts on an industrial scale, thanks to the reusability of the support bath.

LANGMUIR (2021)

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Article Engineering, Biomedical

Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity

Yin Shi et al.

Summary: This study presents a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance antimicrobial efficacy while avoiding side effects. The developed surface-nanoengineered antimicrobial liposome (SNAL) possesses virus-like infection to bacterial cells, mediating high-efficiency bacteria binding, rapid attack, and irreversible damage of cell membrane. The viral mimics show promising effectiveness against multiple pathogens and low toxicity, suggesting potential for next-generation antimicrobial design.

BIOACTIVE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Liming Lin et al.

Summary: Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or anticarcinogens that disrupt cell membranes, potentially serving as future therapeutics in the drug-resistant era. Experimental evidence suggests that MDPs can also be utilized as adjuvants to enhance the therapeutic effects of other agents.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Nanoscience & Nanotechnology

Recent advances of MXenes as electrocatalysts for hydrogen evolution reaction

Saishuai Bai et al.

Summary: MXenes, an emerging two-dimensional transition metal carbides, have shown great potential as electrocatalysts for hydrogen evolution reaction. This comprehensive study summarizes the preparation, applications, and strategies for enhancing the catalytic activity of MXenes, as well as identifying the existing challenges and new opportunities for MXenes-based electrocatalysts.

NPJ 2D MATERIALS AND APPLICATIONS (2021)

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Article Nanoscience & Nanotechnology

Structural Superiority of Guanidinium-Rich, Four-Armed Copolypeptides: Role of Multiple Peptide-Membrane Interactions in Enhancing Bacterial Membrane Perturbation and Permeability

Jing Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Construction of Chitosan-Based Hydrogel Incorporated with Antimonene Nanosheets for Rapid Capture and Elimination of Bacteria

Yingnan Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Intracellular bacteria destruction via traceable enzymes-responsive release and deferoxamine-mediated ingestion of antibiotics

Maohua Chen et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Engineering, Biomedical

Surface modification of black phosphorus-based nanomaterials in biomedical applications: Strategies and recent advances

Guodong Zeng et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

Synergistic Antimicrobial Titanium Carbide (MXene) Conjugated with Gold Nanoclusters

Kaiyuan Zheng et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Engineering, Biomedical

Unnatural Amino-Acid-Based Star-Shaped Poly(l-Ornithine)s as Emerging Long-Term and Biofilm-Disrupting Antimicrobial Peptides to TreatPseudomonas aeruginosa-Infected Burn Wounds

Miao Pan et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Engineering, Biomedical

Injectable biodegradation-visual self-healing citrate hydrogel with high tissue penetration for microenvironment-responsive degradation and local tumor therapy

Min Wang et al.

BIOMATERIALS (2020)

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Review Medicine, Research & Experimental

Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

Linqiang Mei et al.

THERANOSTICS (2020)

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Article Materials Science, Biomaterials

Surface modification engineering of two-dimensional titanium carbide for efficient synergistic multitherapy of breast cancer

Lei Bai et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Pharmacology & Pharmacy

PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections

Minghao Sun et al.

DRUG DELIVERY (2020)

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Article Materials Science, Biomaterials

A pirfenidone loaded spray dressing based on lyotropic liquid crystals for deep partial thickness burn treatment: healing promotion and scar prophylaxis

Jintian Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Multidisciplinary

Two-dimensional composite of D-Ti3C2Tx@S@TiO2 (MXene) as the cathode material for aluminum-ion batteries

Xiaogeng Huo et al.

NANOSCALE (2020)

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Article Nanoscience & Nanotechnology

Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers

Fan Qi et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Ultrathin Molybdenum Carbide MXene with Fast Biodegradability for Highly Efficient Theory-Oriented Photonic Tumor Hyperthermia

Wei Feng et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Review Engineering, Environmental

Preparations, properties and applications of low-dimensional black phosphorus

Chao Xing et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Article Pharmacology & Pharmacy

Metal-Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Biyuan Wu et al.

PHARMACEUTICS (2019)

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Article Engineering, Biomedical

Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection

Ge Gao et al.

BIOMATERIALS (2019)

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Article Biotechnology & Applied Microbiology

An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy

Menglong Liu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Medicine, Research & Experimental

Thermo-sensitive gel in glaucoma therapy for enhanced bioavailability: In vitro characterization, in vivo pharmacokinetics and pharmacodynamics study

Youmei Zeng et al.

LIFE SCIENCES (2018)

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Article Electrochemistry

Colloidal Properties and Stability of 2D Ti3C2 and Ti2C MXenes in Water

A. Rozmyslowska et al.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE (2018)

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Article Chemistry, Multidisciplinary

Antimicrobial Mode-of-Action of Colloidal Ti3C2TX MXene Nanosheets

Ahmad Arabi Shamsabadi et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2018)

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Article Chemistry, Multidisciplinary

Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion

Han Lin et al.

NANO LETTERS (2017)

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Review Chemistry, Multidisciplinary

Two-Dimensional Nanomaterials for Cancer Nanotheranostics

Yongjiu Chen et al.

SMALL (2017)

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Review Nanoscience & Nanotechnology

Study of Graphene Oxide Structural Features for Catalytic, Antibacterial, Gas Sensing, and Metals Decontamination Environmental Applications

Shamaila Sajjad et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Multidisciplinary

Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm

Dengfeng Hu et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

Photoluminescent Ti3C2 MXene Quantum Dots for Multicolor Cellular Imaging

Qi Xue et al.

ADVANCED MATERIALS (2017)

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Article Chemistry, Multidisciplinary

MXene Ti3C2: An Effective 2D Light-to-Heat Conversion Material

Renyuan Li et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

Antibacterial Activity of Ti3C2Tx MXene

Kashif Rasool et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Organic-Base-Driven Intercalation and Delamination for the Production of Functionalized Titanium Carbide Nanosheets with Superior Photothermal Therapeutic Performance

Jinnan Xuan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Microbiology

Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms

Kevin D. Mlynek et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

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Article Polymer Science

Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure

Steven J. Shirbin et al.

ACS MACRO LETTERS (2016)

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Article Multidisciplinary Sciences

Conductive two-dimensional titanium carbide 'clay' with high volumetric capacitance

Michael Ghidiu et al.

NATURE (2014)

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Article Engineering, Biomedical

Self-assembly of ciprofloxacin and a tripeptide into an antimicrobial nanostructured hydrogel

Silvia Marchesan et al.

BIOMATERIALS (2013)

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Article Multidisciplinary Sciences

Cation Intercalation and High Volumetric Capacitance of Two-Dimensional Titanium Carbide

Maria R. Lukatskaya et al.

SCIENCE (2013)

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Article Chemistry, Multidisciplinary

Two-Dimensional Nanocrystals Produced by Exfoliation of Ti3AlC2

Michael Naguib et al.

ADVANCED MATERIALS (2011)

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Titanium carbide MXene-based hybrid hydrogel for chemo-photothermal combinational treatment of localized bacterial infection

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