期刊
ACTA BIOMATERIALIA
卷 137, 期 -, 页码 199-217出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2021.10.008
关键词
Black phosphorus quantum dots; Nanohydrogel; Photothermal therapy; Antibacterial; Diabetic wound healing
资金
- National Natural Science Foun-dation of China [82072076, 82072165]
In this study, black phosphorus quantum dots encapsulated in a hydrogel were utilized as a nanoplatform for the treatment of multidrug-resistant bacteria-induced infections, showing good inhibitory effects on MRSA and promoting wound healing in animal experiments with good biocompatibility demonstrated.
Multidrug-resistant (MDR) bacteria-induced infection is becoming a huge challenge for clinical treat-ment, especially for non-healing diabetic wound infections, which increase patient mortality. MRSA in-fections and delayed wound healing (methicillin-resistant Staphylococcus aureus) accounted for a higher proportion. Although surgical debridement and continuous use of antibiotics are still the main clinical treatments, new multifunctional therapeutic nanoplatform are attractive for MIDW. Thus, in the present study, black phosphorus quantum dots (BPQDs) encapsulated in hydrogel (BPQDs@NH) were utilized as nanoplatforms for MIDW treatment to achieve the multifunctional properties of NIR (near infrared) re-sponsiveness, ROS (reactive oxygen species) generation and antibacterial activity. Upon NIR irradiation, the temperature of the BPQDs@NH-treated MIDW area rapidly increased up to 55 degrees C for sterilization. In vitro experiments showed that BPQDs@NH exerted a synergistic effect on inhibiting MRSA by produc-ing of ROS, lipid peroxidation, glutathione, adenosine triphosphate accumulation and bacterial membrane destruction upon NIR irradiation. The resulting BPQDs@NH achieved an effective sterilization rate of ap-proximately 90% for MRSA. Furthermore, animal experiments revealed that BPQDs@NH achieved an ef-fective closure rate of 95% for MIDW after 12 days by reducing the inflammatory response and regulating the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Meanwhile, intravenous circulation experiments showed good biocompatibility of BPQDs, and no obvi-ous damage to rat major organs was observed. The obtained results indicated that BPQDs@NH achieved the synergistic functions of NIR-responsiveness, ROS generation, and antibacterial activity and promoted wound healing, suggesting that they are promising multifunctional nanoplatforms for MIDW healing. Statement of significance 1. NIR-triggered ROS-generating and antibacterial nanoplatforms are attractive in the wound healing field. 2. In this work, black phosphorus quantum dots encapsulated in a hydrogel were used as a nanoplatform for treating MRSA infected wounds. 3. The obtained materials have achieved an effective sterilization rate for MRSA and effective wound closure rate.(C) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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